Association between the proportion of <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> infections detected by passive surveillance and the... (Publications)
proportion of infections detected in routine malaria data, P(Detect), was derived from paired household cross-sectional survey and routinely collected malaria data within health facilities. P(Detect) was [...] BACKGROUND: Passively collected malaria case data are the foundation for public health decision making. However, because of population-level immunity, infections might not always be sufficiently symptomatic [...] model in 431 clusters spanning the Americas, Africa, and Asia. The...
Dengue fever in Dar es Salaam, Tanzania: clinical features and outcome in populations of black and non-black racial category (Publications)
are under-reported in Africa and often mistaken for malaria. These results highlight the need to introduce point-of-care tests, beside the one for malaria, to detect outbreaks and orientate diagnosis. TRIAL [...] clinical presentation, including warning signs, was assessed by logistic regression adjusted for age, malaria coinfection, secondary dengue and duration of symptoms at inclusion. The independent association [...] attended care after a slightly longer duration of symptoms (median of 2.9...
Clonal expansion of artemisinin-resistant <em>Plasmodium falciparum</em> in Uganda is associated with substandard treatment practices (Publications)
the frame of the Community Access to Rectal Artesunate for Malaria project, blood samples were collected from children with signs of severe malaria before and after RAS implementation. K13 polymorphisms were [...] a driver of this recent emergence. Rectal artesunate (RAS) as pre-referral treatment for severe malaria in children was implemented in 2019 in Northern Uganda. The objective of this study was to determine
The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue (Publications)
cavity of the enzyme. Like MB, also PYO was also found to be active against blood schizonts of the malaria parasite P. falciparum in vitro. Furthermore, both compounds were active against the disease transmitting [...] PYO, is well tolerated and represents a promising agent for MB-based combination therapies against malaria. Current and future clinical studies can be guided by the comparisons between MB and PYO reported [...] reported here. Additionally, it is of interest to study if and to what...
Feasibility of repellent use in a context of increasing outdoor transmission: a qualitative study in rural Tanzania (Publications)
long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) has substantially reduced malaria morbidity and mortality in sub-Saharan Africa. These tools target indoor resting and biting vectors [...] may select for vectors that bite and rest outdoors. Thus, to significantly impact this residual malaria transmission outdoors, tools targeting outdoor transmission are required. Repellents, used for personal [...] hinges upon its community acceptability. This study assessed the...
Spatial effects of mosquito bednets on child mortality (Publications)
Insecticide treated nets (ITN) have been proven to be an effective tool in reducing the burden of malaria. Few randomized clinical trials examined the spatial effect of ITNs on child mortality at a high [...] coverage. We analyzed for the first time data from a large follow-up study in an area of high perennial malaria transmission in southern Tanzania to describe the spatial effects of bednets on all-cause child mortality [...] with insecticide, and (2) the relative homogeneity of coverage with...
Spatial risk profiling of <em>Plasmodium falciparum</em> parasitaemia in a high endemicity area in Côte d'Ivoire (Publications)
in a high endemicity area of Africa, and to specify how this information can facilitate improved malaria control at the district level. METHODS: A questionnaire was administered to about 4,000 schoolchildren [...] parasitaemia. After accounting for spatial correlation, age, bed net coverage, rainfall during the main malaria transmission season and distance to rivers remained significant covariates. CONCLUSION: It is argued [...] villages in close proximity to rivers, in concert with other...
The influence of zinc supplementation on morbidity due to <em>Plasmodium falciparum</em>: a randomized trial in preschool children in Papua New Guinea (Publications)
determine the influence of zinc on malaria morbidity we conducted a randomized placebo-controlled trial of daily zinc supplementation in children residing in a malaria endemic region of Papua New Guinea [...] mg elemental zinc (n = 136) or placebo (n = 138) for 6 days a week for 46 weeks. Slide-confirmed malaria episodes were detected by surveillance of cases self-reporting to a local health center. Cross-sectional
Estimating the duration of Plasmodium falciparum infection from trials of indoor residual spraying (Publications)
cross-sectional survey data collected from three historical trials of indoor residual spraying against malaria: one from two contiguous districts in Tanzania-Kenya (Pare Taveta) carried out in 1954, the others [...] showed considerable variation but no general age trend. There was also no clear relationship between malaria endemicity and infection duration. Analyses of successive sampling from the same individuals with [...] areas. Periods of several years may be required to evaluate long-term...
Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in<em> Plasmodium falciparum</em> protein export (Publications)
Malaria blood stage parasites export a large number of proteins into their host erythrocyte to change it from a container of predominantly hemoglobin optimized for the transport of oxygen into a niche [...] how many further PNEPs exist. Here we report the identification of new PNEPs in the most virulent malaria parasite Plasmodium falciparum. This includes proteins with a domain structure deviating from previously [...] highlighting protein translocation in the parasite periphery as a general...