Bicyclic amido compounds with antiprotozoal activity (Publications)
tested for their activities against the causative organisms of East African trypanosomiasis and malaria tropica. The acylation induced in general loss of antiprotozoal activity, but a single compound showed
Diaryl ureas as an antiprotozoal chemotype (Publications)
kinetic aq. solubilities were /=10. One N,N'-diarylurea had demonstrable activity in mouse models of malaria and toxoplasmosis.
SARs of the antiprotozoal action of 6,7-diaryl-bicyclo[2.2.2]octan-2-ols (Publications)
tested for their activity against the causative organisms of East African sleeping sickness and malaria tropica. Structure activity relationships are discussed
Synthesis of szentiamide, a depsipeptide from entomopathogenic <em>Xenorhabdus szentirmaii</em> with activity against <em>Plasmodium falciparum</em> (Publications)
on of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria
A paradigm for Africa-centric vaccine development in Equatorial Guinea (Publications)
The Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development
Inference for entomological semi-field experiments: fitting a mathematical model assessing personal and community protection of vector-control... (Publications)
and metofluthrin spatial repellents, as well as combined interventions for Plasmodium falciparum malaria in Anopleles minimus. Overall, all interventions had both personal and community effects, preventing [...] than just reduction in biting, to be parameterised and highlights the tools assessed as promising malaria interventions.
A comparative study of the efficacies of chloroquine and a pyrimethamine-dapsone combination in clearing <em>Plasmodium falciparum</em> parasitaemia... (Publications)
100 mg dapsone for children 10 or more years old) as a single dose. Children were followed-up for malaria parasitaemia at days 2, 7 and 14 after screening, randomization and treatment. The slide positivity [...] pyrimethamine-dapsone appears to be a better choice than chloroquine as a chemoprophylactic regimen for malaria in this area. Although they need to be confirmed in a larger study, these results may be of interest
Antibodies elicited by a virosomally formulated <em>Plasmodium falciparum</em> serine repeat antigen-5 derived peptide detect the processed 47kDa... (Publications)
Serine repeat antigen-5 (SERA5) is a candidate antigen for inclusion into a malaria subunit vaccine. During merozoite release and reinvasion the 120kDa SERA5 precursor protein (P120) is processed, and [...] peptide FB-23 is suitable for use in humans and represents a candidate component for a multi-valent malaria subunit vaccine targeting both sporozoites and blood stage parasites
Quality and comparison of antenatal care in public and private providers in the United Republic of Tanzania (Publications)
dispensing prophylactic drugs against anaemia or malaria were not respected, and diagnostic examinations for the assessment of gestation, anaemia, malaria or urine infection were frequently not performed
Sequence and diversity of T-cell receptor alpha <em>V</em>, <em>J</em>, and <em>C</em> genes of the owl monkey <em>Aotus nancymaae</em> (Publications)
which are susceptible to infection with the human malaria parasite Plasmodium falciparum, as an animal model for the evaluation of molecularly defined malaria vaccine candidates