Comparative ex vivo activity of novel endoperoxides in multidrug-resistant <em>Plasmodium falciparum</em> and <em>P. vivax</em> (Publications)
potent compounds for the treatment of malaria. In Papua Indonesia, where multidrug resistance has been documented against both P. falciparum and P. vivax malaria, comparative ex vivo antimalarial activity
Detection of <em>Plasmodium falciparum</em> infected <em>Anopheles gambiae</em> using near‑infrared spectroscopy (Publications)
demonstrates proof-of-concept that NIRS is capable of rapidly identifying laboratory strains of human malaria infection in African mosquito vectors. CONCLUSIONS: Accurate, low-cost, reagent-free screening of [...] by NIRS could revolutionize surveillance and elimination strategies for the most important human malaria parasite in its primary African vector species. Further research is needed to evaluate how the method
Acceptability and use of insecticide impregnated bednets in northern Ghana (Publications)
washing soaps could improve protection for young children. The success of the promotion of IIBNs in malaria control programmes will depend on the cost of the package and the time of year that it is delivered [...] the intervention in this study, and it should be included as an important component of national malaria control programmes.
Efficacy and safety of moxidectin, synriam, synriam-praziquantel <em>versus</em> praziquantel against <em>Schistosoma haematobium</em> and <em>S.... (Publications)
analysis or three urine samples (S. haematobium trial) for urine filtration and one finger prick for malaria screening at baseline and follow-up. Participants were randomly assigned to either moxidectin, Synriam [...] hence an ancillary benefit is not expected when these drugs are used for treating onchocerciasis and malaria in co-endemic settings. Further studies are needed to corroborate our findings that moxidectin and
Vaccination with virosomally formulated recombinant CyRPA elicits protective antibodies against<em> Plasmodium falciparum</em> parasites in... (Publications)
emerged as a promising blood-stage candidate antigen for inclusion into a broadly cross-reactive malaria vaccine. This highly conserved protein among various geographical strains plays a key role in the [...] falciparum merozoites, and antibodies against PfCyRPA can efficiently prevent the entry of the malaria parasites into red blood cells. The aim of the present study was to develop a humancompatible formulation
Activation of TCR Vδ1+ and Vδ1-Vδ2- γδ T cells upon controlled infection with <em>Plasmodium falciparum</em> in Tanzanian volunteers (Publications)
immune response to malaria remains incomplete. Clinical trials using whole-sporozoite-based vaccination approaches such as the Sanaria PfSPZ Vaccine, followed by controlled human malaria infection (CHMI)
Inhibitors of Plasmepsin II-potential antimalarial agents (Publications)
In order to overcome the problem of drug resistance in malaria, it appears wise to concentrate drug discovery efforts toward new structural classes and new mechanisms of action. We report our results,
Synthesis and evaluation of beta-carbolinium cations as new antimalarial agents based on pi-delocalized lipophilic cation (DLC) hypothesis (Publications)
efficacy. beta-Carbolinium compounds exhibit medium suppressive activity in vivo against rodent malaria
Antiprotozoal activities of epimeric aminobicycles (Publications)
sleeping sickness, and Plasmodium falciparum K-1, a multiresistant protozoan parasite which causes Malaria tropica. The results are compared to the activities of their formerly synthesized stereoisomers and
Long-lasting and fast-acting<em> in vivo</em> efficacious antiplasmodial azepanylcarbazole amino alcohol (Publications)
With approximately 429,000 deaths in 2016, malaria remains a major infectious disease where the need to treat the fever symptoms, but also to provide relevant post-treatment prophylaxis, is of major importance