Measuring health facility readiness and its effects on severe malaria outcomes in Uganda (Publications)
role of health service delivery to the malaria decline in Uganda We developed a methodology to quantify health facility readiness and assessed its role on severe malaria outcomes among lower-level facilities [...] facilities (HCIIIs and HCIIs) in the country. Malaria data was extracted from the Health Management Information System (HMIS). General service and malaria-specific readiness indicators were obtained from the [...] factorial axes. Geostatistical models assessed the effect of facility...
Mass drug administration for malaria elimination: do we understand the settings well enough? (Publications)
tool for interrupting malaria transmission, but evidence from low endemicity settings is scarce. A trial in Zanzibar found that two rounds of MDA made no significant impact on malaria incidence, and many
Investigating sulfoxide-to-sulfone conversion as a prodrug strategy for a phosphatidylinositol 4-kinas inhibitor in a humanized mouse model of malaria (Publications)
its corresponding sulfone metabolite, were evaluated in the NOD-scid IL2Rgamma(null) (NSG) murine malaria disease model of Plasmodium falciparum infection. We hypothesized that the sulfoxide would serve [...] dosed, thereby demonstrating that the sulfoxide served as an effective prodrug for the treatment of malaria.
Community-based prevalence of typhoid fever, typhus, brucellosis and malaria among symptomatic individuals in Afar Region, Ethiopia (Publications)
650 suspected individuals for malaria, 16 (2.5%) were found positive for P. falciparum infection. CONCLUSION: In this study, typhoid fever, typhus, brucellosis and malaria were observed among symptomatic [...] scarcity of proper diagnostic tools, febrile illness related symptoms are often misdiagnosed as malaria. Information on causative agents of febrile illness related symptoms among pastoral communities in [...] based cross-sectional survey, we assessed the prevalence of typhoid fever,...
Mass campaigns combining antimalarial drugs and anti-infective vaccines as seasonal interventions for malaria control, elimination and prevention of... (Publications)
of existing malaria interventions is becoming increasingly important as evidence mounts that progress on reducing malaria incidence is stalling and threatened by resistance. METHODS: Malaria transmission [...] on and intervention dynamics were simulated using OpenMalaria, an individual-based simulation model of malaria transmission, by considering a seasonal transmission setting and by varying epidemiological [...] of seasonal mass applications of preventative anti-infective malaria vaccines,...