Molecular epidemiology and seroprevalence in asymptomatic <em>Plasmodium falciparum</em> infections of Malagasy pregnant women in the highlands (Publications)
BACKGROUND: Malaria epidemiology in Madagascar is classified into four different areas, ranging from unstable seasonal transmission in the highlands to hyperendemic perennial transmission areas in the [...] the costal level. Most malaria studies in Madagascar are focused on symptomatic children. However, because of the low transmission in some areas with correspondingly low level of semi-immunity, adults are [...] genetic epidemiology of malarial infections in pregnant women in order to provide...
Analysis of diagnostic findings from the European mobile laboratory in Gueckedou, Guinea, March 2014 through March 2015 (Publications)
2015. METHODS: The unit diagnosed EVD and malaria, using the RealStar Filovirus Screen reverse transcription-polymerase chain reaction (RT-PCR) kit and a malaria rapid diagnostic test, respectively. RESULTS:
Next generation chemiluminescent probes for antimalarial drug discovery (Publications)
Malaria is caused by parasites of the Plasmodium genus and remains one of the most pressing human health problems. The spread of parasites resistant to or partially resistant to single or multiple drugs [...] frontline antimalarial artemisinin and its derivatives, poses a serious threat to current and future malaria control efforts. In vitro drug assays are important for identifying new antimalarial compounds and [...] detection limit of less than 100 parasites of the presented biosensor system...
Comparison of analytical methods for the evaluation of antibody responses against epitopes of polymorphic protein antigens (Publications)
Surface exposed protein antigens of the malaria parasite Plasmodium falciparum frequently harbor multiple dimorphic amino acid positions. These are associated with parasite immune evasion and represent [...] the humoral immune response against a semiconserved sequence (YX(44)LFX(47)KEKMX(52)L) of the key malaria blood stage vaccine candidate merozoite surface protein-1 (MSP-1). Monoclonal antibodies (mAbs) raised [...] MSP-1(43-53) variant sequences. When used for the evaluation of humoral...
Artemisinins and synthetic trioxolanes in the treatment of helminth infections (Publications)
following recommended malaria treatment schedules, found an effect against schistosomiasis. SUMMARY: Artemisinin-based combination therapies are increasingly deployed against malaria, and hence there is [...] that artemisinin-based combination therapy might have on trematode infections in settings where malaria and helminthiases are co-endemic. RECENT FINDINGS: The artemisinins and synthetic trioxolanes possess
Ethnobotanical study of some of mosquito repellent plants in north-eastern Tanzania (Publications)
potential for malaria vector control requires evaluation in areas with different level of malaria endemicity. The essential oils of Ocimum suave and Ocimum kilimandscharicum were evaluated against malaria vectors [...] filter papers impregnated with Ocimum extracts, knockdown effects and mortality was investigated on malaria mosquito Anopheles arabiensis and Anopheles gambiae, including a nuisance mosquito, Culex quinqu
Modelling the impact of insecticide-based control interventions on the evolution of insecticide resistance and disease transmission (Publications)
threshold level of mosquitoes below which transmission of malaria is interrupted. It is based on a classic Ross-Macdonald derivation of the malaria basic reproductive number (R0) and may be used to assess [...] (iv) the impact of resistance once it has arisen and, in particular, whether it is sufficient for malaria transmission to resume. The model consists of a system of difference equations that tracks the immature [...] and easily generalizable to many scenarios using different calibrations...
Strong off-target antibody reactivity to malarial antigens induced by RTS,S/AS01E vaccination is associated with protection (Publications)
lower clinical malaria incidence after adjusting for age group, site and post-vaccination anti-CSP levels. RTS,S/AS01E-induced IgG may bind strongly not only to CSP, but to unrelated malaria antigens, and [...] and this seems to either confer, or at least be a marker of, increased protection from clinical malaria.
Antimalarial agents derived from metal-amodiaquine complexes with activity in multiple stages of the <em>Plasmodium</em> life cycle (Publications)
Malaria is the one of the deadliest infectious diseases worldwide. Chemically, quinolines are excellent ligands for metal coordination and are deployed as drugs for malaria treatment. There is a growing [...] coordination with antimalarial quinolines is a potential chemical tool for drug design and discovery in malaria and other infectious diseases susceptible to quinoline treatment.
Enhancing the routine health information system in rural southern Tanzania: successes, challenges and lessons learned (Publications)
supervision visits. Clinical data included malaria blood slides and haemoglobin colour scale results. Quality of captured data was assessed using double data entry. Malaria blood slide results from health centre [...] 2006-March 2007), 7056 attendances were recorded in 9880 infants aged 2-11 months, 50% with clinical malaria. Monthly supervision visits highlighted incomplete recording of information between OPD and laboratory