The AvecNet Trial to assess whether addition of pyriproxyfen, an insect juvenile hormone mimic, to long-lasting insecticidal mosquito nets provides... (Publications)
may enhance malaria control, as well as reducing the spread of pyrethroid-resistant mosquitoes. This trial will determine whether PPF-LLINs provide incremental protection against malaria over current [...] BACKGROUND: Recent reductions in malaria in sub-Saharan Africa have been associated with increased coverage with long-lasting insecticidal nets (LLINs). Pyrethroids are currently the only insecticide class [...] PPF-LLIN (containing 2% permethrin and 1% pyriproxyfen w/w) provide better...
The effect of immunization schedule with the malaria vaccine candidate RTS,S/AS01E on protective efficacy and anti-circumsporozoite protein antibody... (Publications)
BACKGROUND: The malaria vaccine RTS,S induces antibodies against the Plasmodium falciparum circumsporozoite protein (CSP) and the concentration of Immunoglobulin G (IgG) against the repeat region of CSP [...] CSP following vaccination is associated with protection from P. falciparum malaria. So far, only the quantity of anti-CSP IgG has been measured and used to predict vaccination success, although quality [...] following second and third RTS,S/AS01E injection was associated with a 54% risk...
Malaria control strategies in the Kilombero Valley, Tanzania (Publications)
Malaria is major public health problem in Tanzania and increasing trends have been observed in the last two decades. A significant consequence of repeated malaria infections in high transmission areas [...] indicating a potential benefit for reducing malaria transmission. The unacceptably high chloroquine failure rates call for an urgent review of the National Malaria Treatment Guidelines. The decision to change [...] areas is anaemia in very young children. The control of malaria in Tanzania...