El-Ninõ Southern Oscillation (ENSO) and annual malaria incidence in Southern Africa (Publications)
We evaluated the association between annual malaria incidence and El Niño Southern Oscillation (ENSO) as measured by the Southern Oscillation Index (SOI) in five countries in Southern Africa from 1988 [...] 1988 to 1999. Below normal incidence of malaria synchronised with a negative SOI (El Niño) and above normal incidence with a positive SOI (La Niña), which lead to dry and wet weather conditions, respectively [...] respectively. In most countries there was a positive relationship between SOI...
Intermittent preventive treatment for malaria and anaemia control in Tanzanian infants; the development and implementation of a public health strategy (Publications)
ased strategy for the implementation of intermittent preventive treatment in infants (IPTi) for malaria and anaemia control in Tanzania. From the outset, a research team worked with staff from all levels
Improving malaria home treatment by training drug retailers in rural Kenya (Publications)
Recent global malaria control initiatives highlight the potential role of drug retailers to improve access to early effective malaria treatment. We report on the findings and discuss the implications of [...] of private drug retailers in control strategies aiming to improve prompt effective treatment of malaria
Targeting <em>Plasmodium</em> PI(4)K to eliminate malaria (Publications)
Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH kinase (PI(4)K), as the [...] azines demonstrate potent preventive, therapeutic, and transmission-blocking activity in rodent malaria models, are active against blood-stage field isolates of the major human pathogens P. falciparum [...] to identify drugs with an ideal activity profile for the prevention, treatment and...
A molecular marker of artemisinin-resistant <em>Plasmodium falciparum</em> malaria (Publications)
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular