Sex: how malaria parasites get turned on (Publications)
initiation of this cell fate decision, ultimately providing the malaria community with a novel and important tool in the battle to prevent malaria transmission.
Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria (Publications)
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on [...] Altogether, these findings provide a mechanistic link between EVs and vascular dysfunction during malaria infection.
Malaria: «Einstein» und die Spritze der Hoffnung (Publications)
In Afrika läuft die weltweit erste Impfkampagne gegen Malaria. In Ghana, Malawi und Kenia werden bis 2022 gegen zwei Millionen Kleinkinder mit dem Vakzin «RTS’S» geimpft. «Einstein» hat die Entwicklung [...] begleitet. Die Langzeit-Dokumentation zeigt auf, wie schwierig der Weg zur ersehnten neuen Waffe gegen Malaria war. Die Schweiz spielte bei der Entwicklung des Impfstoffs eine tragende Rolle, doch die Testreihen [...] und echte Forschungspartnerschaft zwischen Nord und Süd möglich war. Die...
An interactive application for malaria elimination transmission and costing in the Asia-Pacific (Publications)
eliminate malaria in the region by 2030. The emergence and spread of artemisinin drug resistance in the Greater Mekong Subregion makes elimination urgent and strategic for the global goal of malaria eradication [...] regional, country and local settings, which means that different strategies are needed to eliminate malaria. However, models and their predictions can be seen as highly technical, limiting their use for decision [...] , we designed and developed an interactive application to...
PCR correction strategies for malaria drug trials: updates and clarifications (Publications)
Malaria drug trials conducted in endemic areas face a major challenge in their analysis because it is difficult to establish whether parasitaemia in blood samples collected after treatment indicate drug [...] public and private bodies who are working on the development, deployment, and surveillance of new malaria drugs. We aim to promote discussion around these issues and argue for the adoption of improved s
Eave ribbons treated with transfluthrin can protect both users and non-users against malaria vectors (Publications)
treated with spatial repellents effectively prevent human exposure to outdoor-biting and indoor-biting malaria mosquitoes, and could constitute a scalable and low-cost supplement to current interventions, such [...] ribbons alone. CONCLUSION: Transfluthrin-treated eave ribbons protect both users and non-users against malaria mosquitoes indoors and outdoors. The mosquito-killing property of transfluthrin can magnify the communal
Multiplicity of asymptomatic <em>Plasmodium falciparum </em>infections and risk of clinical malaria: a systematic review and pooled analysis of... (Publications)
subsequent febrile malaria or with an increased risk. CONCLUSIONS: The number of clones in asymptomatic P. falciparum infections is associated with different risks of subsequent clinical malaria depending on [...] BACKGROUND: The malaria parasite Plasmodium falciparum holds an extensive genetic polymorphism. In this pooled analysis, we investigate how the multiplicity, i.e. the number of co-infecting clones, in [...] in asymptomatic P. falciparum infections affects the subsequent risk of...
Mass campaigns combining antimalarial drugs and anti-infective vaccines as seasonal interventions for malaria control, elimination and prevention of... (Publications)
of existing malaria interventions is becoming increasingly important as evidence mounts that progress on reducing malaria incidence is stalling and threatened by resistance. METHODS: Malaria transmission [...] on and intervention dynamics were simulated using OpenMalaria, an individual-based simulation model of malaria transmission, by considering a seasonal transmission setting and by varying epidemiological [...] of seasonal mass applications of preventative anti-infective malaria vaccines,...
The <em>Plasmodium falciparum</em> Hsp70-x chaperone assists the heat stress response of the malaria parasite (Publications)
Plasmodium falciparum is the most lethal of human-infective malaria parasites. A hallmark of P. falciparum malaria is extensive remodeling of host erythrocytes by the parasite, which facilitates the d [...] Vakonakis, I. The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite.