Mapping routine malaria incidence at village level for targeted control in Papua New Guinea (Publications)
Malaria surveillance and response-systems are essential for identifying the areas most affected by malaria and for targeting interventions and optimising resources. This study aimed to assess whether the
Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in... (Publications)
BACKGROUND: We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducted
Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite <em>Plasmodium falciparum</em> (Publications)
protein 1 (HP1) is important for dynamically regulating its various functions. However, in the malaria parasite Plasmodium falciparum both the function of HP1 phosphorylation and the identity of the protein
Operational coverage and timeliness of reactive case detection for malaria elimination in Zanzibar, Tanzania (Publications)
Since 2012, the Zanzibar Malaria Elimination Program has been implementing reactive case detection (RACD). Health facility (HF) staff send individual malaria case notifications by using mobile phones, [...] triggering a review of HF records and malaria testing and treatment at the household level by a district malaria surveillance officer. We assessed the completeness and timeliness of this system, from [...] Zanzibar achieved high operational coverage, timeliness was suboptimal. Patients...
Repeated mosquito net distributions, improved treatment, and trends in malaria cases in sentinel health facilities in Papua New Guinea (Publications)
RESULTS: Malaria incidence initially ranged from 20 to 115/1000 population; subsequent trends varied by site. Overall, LLIN distributions had a cumulative effect, reducing the number of malaria cases with [...] not ACT, were associated with reductions of malaria cases in a range of settings, but sustainability of the gains appear to depend on local factors. Malaria programmes covering diverse transmission settings [...] al nets (LLIN), improved diagnosis and artemisinin-based combination therapy...
The potential of pregnant women as a sentinel population for malaria surveillance (Publications)
Monthly ANC malaria test-positivity data from all Tanzanian health facilities for January 2014 to May 2016 was compared to prevalence data from the School Malaria Parasitaemia Survey 2015, the Malaria Indicator [...] proposed as a pragmatic sentinel population for malaria surveillance. However, the representativeness of routine ANC malaria test-positivity and its relationship with prevalence in other population subgroups [...] Indicator Survey (MIS) 2015/16, the Malaria Atlas Project 2015, and a...
Resurgence of malaria infection after mass treatment: a simulation study (Publications)
management, and test-and-treat interventions. Individual-based stochastic models of malaria transmission (OpenMalaria) were then used to estimate the probability and likely rates of resurgence in realistic [...] if mass drug administration (MDA) might shorten the time to elimination of Plasmodium falciparum malaria, when vector control measures and reactive surveillance strategies are scaled-up. A concern with [...] of bistability. Importation rates are important only when this threshold is very...
Videographic analysis of flight behaviours of host-seeking <em>Anopheles arabiensis</em> towards BG-Malaria trap (Publications)
The BG-Malaria trap (BGM) is an adaptation of the well-known BG-Sentinel trap (BGS) with greater trapping efficiencies for anopheline and culicine mosquitoes. Its continued optimization requires greater
Mosquito feeding behavior and how it influences residual malaria transmission across Africa (Publications)
an estimated 10.6 million additional malaria cases annually if universal LLIN and IRS coverage was achieved. Higher outdoor biting diminishes the cases of malaria averted by vector control. This reduction [...] times contribute to residual transmission which determines the maximum effectiveness of current malaria prevention. The likelihood mosquitoes feed outside the time of day when LLINs and IRS can protect [...] estimate the public health impact of outdoor biting across Africa. On average 79%...