Mapping multiple components of malaria risk for improved targeting of elimination interventions (Publications)
component, related mappable malaria metrics are also described which may be measured and evaluated by malaria programmes seeking to better understand the determinants of malaria risk. Implementing tailored [...] There is a long history of considering the constituent components of malaria risk and the malaria transmission cycle via the use of mathematical models, yet strategic planning in endemic countries tends [...] tends not to take full advantage of available disease intelligence to tailor...
Malaria prevention recommendations for risk groups visiting sub-Saharan Africa: a survey of European expert opinion and international recommendations (Publications)
INTRODUCTION: Malaria prevention can be complex due to the individual characteristics of the traveller, travel destination, duration of stay and type of travel. Our aim in this study was to document malaria che [...] visiting malaria-endemic areas of sub-Saharan Africa. METHODS: Travel medicine experts in Europe were asked to complete an online questionnaire, a 28-item Survey Monkey survey, on 11 malaria prevention [...] of the UK, U.S. CDC, Germany, Switzerland, WHO and the electronic Medicines...
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody (Publications)
Invasion of erythrocytes by Plasmodial merozoites is a composite process involving the interplay of several proteins. Among them, the Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) i
Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models (Publications)
BACKGROUND: The phase 3 trial of the RTS,S/AS01 malaria vaccine candidate showed modest efficacy of the vaccine against Plasmodium falciparum malaria, but was not powered to assess mortality endpoints [...] settings. Decisions about implementation will need to consider levels of malaria burden, the cost-effectiveness and coverage of other malaria interventions, health priorities, financing, and the capacity of the [...] iveness of routine use of the RTS,S/AS01 vaccine in African settings....
Community-based surveillance to monitor mortality in a malaria-endemic and Ebola-epidemic setting in rural Guinea (Publications)
a reinforced malaria control program and one sous-prefecture without (Koundou) in Guinea. Deaths were recorded by key informants and classified as due to malaria or another cause. Malaria deaths were those [...] deaths were reported from July 2011-June 2014, of which 55.2% (N = 686) were reported as due to malaria. Malaria-attributable proportional mortality decreased by 26.5% (95% confidence interval [CI] = 13.9-33 [...] those reported as due to malaria or fever in the 3 days before death with...
Malaria intervention scale-up in Africa: effectiveness predictions for health programme planning tools, based on dynamic transmission modelling (Publications)
(IRS), management of uncomplicated malaria cases (CM) and seasonal malaria chemoprophylaxis (SMC) over a 10-year horizon, over a range of settings with stable endemic malaria. Generalized linear regression [...] intervention impact, to inform a malaria module in the Spectrum health programme planning tool. METHODS: The dynamic Plasmodium falciparum transmission model OpenMalaria was used to simulate health effects [...] entail a partial rebound in malaria mortality among people above 5 years of...
Susceptibility of <em>Anopheles gambiae</em> to insecticides used for malaria vector control in Rwanda (Publications)
a major threat to the gains made in malaria control. To monitor the presence and possible emergence of resistance against a variety of insecticides used for malaria control in Rwanda, nationwide insecticide [...] using the synergist PBO. CONCLUSION: This is the first nationwide study of insecticide resistance in malaria vectors in Rwanda. It shows the gradual increase of insecticide resistance to pyrethroids (lambd [...] testing and implement an insecticide resistance management strategy to...
Nouvelles approches pour la prévention de la malaria chez le voyageur (Publications)
Malaria is declining in many tropical countries. This reduction challenges our usual preventive strategies. In moderate to low risk areas, the Swiss guidelines recommend a stand-by emergency treatment [...] making through three clinical studies. The first showed that travelers visiting moderate to low risk malaria areas prefer a standby emergency treatment rather than chemoprophylaxis. The second study investigates