Epidemiological links between malaria parasitaemia and hypertension: findings from a population-based survey in rural Côte d'Ivoire (Publications)
between malaria parasitaemia and hypertension in Ivorian adults. METHODS: We estimated the adjusted odds ratios (OR) and 95% confidence intervals (CI) of hypertension in relation to malaria parasitaemia [...] mmHg or clinician-diagnosed hypertension. RESULTS: Prevalence of malaria parasitaemia and hypertension were 10 and 22%, respectively. Malaria parasitaemia was negatively associated with hypertension in p [...] Participants having microscopic malaria parasitaemia with elevated body...
Immuno-gold silver staining assays on capillary-driven microfluidics for the detection of malaria antigens (Publications)
a lack of highly sensitive malaria RDTs that can detect low antigen concentration at the onset of infection. Here, we present a strategy to improve the sensitivity of malaria RDTs by using capillary-driven [...] al to the concentration of antigen in a sample. We illustrate this method using the recombinant malaria antigen Plasmodium falciparum histidine-rich-protein 2 (rPfHRP2) spiked in human serum. This antigen [...] min, which is approaching the desired sensitivity needed in the Target...
The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background (Publications)
The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To explore the chain
Measuring health facility readiness and its effects on severe malaria outcomes in Uganda (Publications)
role of health service delivery to the malaria decline in Uganda We developed a methodology to quantify health facility readiness and assessed its role on severe malaria outcomes among lower-level facilities [...] facilities (HCIIIs and HCIIs) in the country. Malaria data was extracted from the Health Management Information System (HMIS). General service and malaria-specific readiness indicators were obtained from the [...] factorial axes. Geostatistical models assessed the effect of facility...
Mass drug administration for malaria elimination: do we understand the settings well enough? (Publications)
tool for interrupting malaria transmission, but evidence from low endemicity settings is scarce. A trial in Zanzibar found that two rounds of MDA made no significant impact on malaria incidence, and many
Evaluation of 4-amino 2-anilinoquinazolines against <em>Plasmodium</em> and other apicomplexan parasites<em> in vitro </em>and in a<em> P.... (Publications)
A series of 4-amino 2-anilinoquinazolines optimized for activity against the most lethal malaria parasite of humans, Plasmodium falciparum, were evaluated for activity against other human Plasmodium parasites
Mosquito repellents for malaria prevention (Review) (Publications)
BACKGROUND: Malaria is an important cause of illness and death across endemic regions. Considerable success against malaria has been achieved within the past decade mainly through long-lasting insecti [...] alone. It is unclear if topical repellents can prevent clinical malaria (RR 0.65, 95% CI 0.4 to 1.07, very low certainty evidence) or malaria infection (RR 0.84, 95% CI 0.64 to 1.12, low-certainty evidence) [...] repellentsTwo cluster-randomized RCTs investigated mosquito coils for malaria...