The risk of malarial infections and disease in Papua New Guinean children (Publications)
vivax = 5.28), they were 21 times more likely to develop symptomatic P. falciparum malaria (1.17/year) than P. vivax malaria (0.06/year). Children greater than nine years of age had a reduced risk of acquiring [...] to symptomatic P. falciparum malaria remained incomplete. These observations suggest that different mechanisms of immunity may be important for protection from these malaria species [...] study of 206 Papua New Guinean school children, we examined risk of reinfection and symptomatic ...
Heterogeneity in P<em>lasmodium falciparum </em>whole sporozoite vaccine induced humoral immune responses and protection in African volunteers: the... (Publications)
geographical overlap of HIV and malaria, an effective malaria vaccine deployed in this population could possibly support the long-term objective of regional elimination of malaria by using mass vaccination. [...] and 405,000 deaths attributed to malaria. New tools such as efficacious vaccines, better drugs and diagnostics are needed to supplement the current malaria control tools that rest mainly on vector control [...] against malaria induced by these whole sporozoite based vaccines varies...
Pyrimethamine-resistant <em>Plasmodium falciparum</em> parasites among Tanzanian children: a facility-based study using the polymerase chain reaction (Publications)
of the 21 children with clinical malaria had pyrimethamine-resistant parasites. Currently, sulfadoxine-pyrimethamine is considered a potential first-line drug for malaria treatment in most African countries [...] used to estimate the proportion of pyrimethamine-resistant parasites in 101 children reporting with malaria at the hospital in Ifakara, a town in southern Tanzania. The method is based on the observation that [...] suggest that although sulfadoxine-pyrimethamine could still be effective...
High levels of genetic diversity of <em>Plasmodium falciparum</em> populations in Papua New Guinea despite variable infection prevalence (Publications)
obstacle to malaria control. Here, we investigate the relationship between local variation in malaria epidemiology and parasite genetic diversity in Papua New Guinea (PNG). Cross-sectional malaria surveys [...] surveys were performed in 14 villages spanning four distinct malaria-endemic areas on the north coast, including one area that was sampled during the dry season. High-resolution msp2 genotyping of 2,147 blood
Aktueller Malariaschutz bei Kurzzeitaufenthalt (Publications)
average of 800 malaria cases are recorded annually in Germany. One person in a hundred dies of the disease. Travel advice given by experienced physicians is essential to raise awareness of malaria risk in endemic [...] endemic areas. Rational mosquito protection on skin and textiles reduces the risk of malaria and other arthropod-transmitted diseases (e. g. dengue fever). Regular intake of an antimalarial drugs to suppress [...] doctor after taking the SET as quickly as possible. These elements...
Defining the next generation of <em>Plasmodium vivax</em> diagnostic tests for control and elimination: target product profiles (Publications)
prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control i [...] interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical [...] clinical attacks without involving another mosquito bite. The diagnosis...
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity (Publications)
known as MMV1557817, and show that it targets multiple stages of the malaria parasite lifecycle, is active in a preliminary mouse malaria model, and has a novel mechanism of action. Excitingly, resistance [...] To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor [...] digestion in asexual parasites. MMV1557817 can kill sexual-stage P....
The relative roles of ANC and EPI in the continuous distribution of LLINs: a qualitative study in four countries (Publications)
through EPI because of a) stronger linkages and involvement between malaria and reproductive health programmes, as compared to malaria and EPI, and b) more complete programme monitoring for ANC-based d [...] Background: The continuous distribution of long-lasting insecticidal nets (LLINs) for malaria prevention, through the antenatal care (ANC) and the Expanded Programme on Immunizations (EPI), is recommended [...] sub-national, and facility-level health staff, and were selected to capture a...
Spatial effects on the multiplicity of <em>Plasmodium falciparum</em> infections (Publications)
homogeneous transmission used in mathematical transmission models for malaria. In the present study an individual-based mathematical malaria transmission model that incorporates multiple parasite clones, variable [...] prevalence or multiplicity of infection (MOI). In traditionally highly malaria endemic regions where most of the population harbours malaria parasites, humans are often infected with multiple parasite clones [...] As malaria is being pushed back on many frontiers and global case...
Using a mobile nanopore sequencing lab for end-to-end genomic surveillance of <em>Plasmodium falciparum</em>: a feasibility study (Publications)
Genomic epidemiology holds promise for malaria control and elimination efforts, for example by informing on Plasmodium falciparum genetic diversity and prevalence of mutations conferring anti-malarial [...] drug resistance. Limited sequencing infrastructure in many malaria-endemic areas prevents the rapid generation of genomic data. To address these issues, we developed and validated assays for P. falciparum [...] resistance markers. We developed a bioinformatics workflow that allows genotyping...