Creating an "enabling environment" for taking insecticide treated nets to national scale: the Tanzanian experience (Publications)
of its population at high risk of malaria by 2005. The country is, therefore, determined to ensure that sustainable malaria control using insecticide-treated nets is carried out on a national scale. CASE [...] INTRODUCTION: Malaria is the largest cause of health services attendance, hospital admissions and child deaths in Tanzania. At the Abuja Summit in April 2000 Tanzania committed itself to protect 60% of [...] been involved for two decades in the research process for developing...
Distribution of survival times of deliberate <em>Plasmodium falciparum</em> infections in tertiary syphilis patients (Publications)
has important implications for mathematical modelling of malaria, which has for the past century exclusively assumed that the duration of malaria infections has an exponential distribution. It is desirable [...] influences the length of monitoring needed in an intervention programme for eliminating or reducing malaria
Contribution of dengue fever to the burden of acute febrile illnesses in Papua New Guinea: an age-specific prospective study (Publications)
were enrolled, and 317 patients with a negative rapid diagnostic test (RDT) for malaria were tested for dengue. Malaria was confirmed in 52% (301/578, 95% confidence interval [CI] = 48-56%), DF was diagnosed [...] Abstract. Malaria is a major contributor to the burden of febrile illnesses in Papua New Guinea (PNG). Dengue fever (DF) is likely to contribute; however, its epidemiology in PNG is poorly understood. [...] diagnosed in 8% (46/578, 95% CI = 6-10%), and 40% (95% CI = 36-44%) had neither...
A multiplex qPCR approach for detection of <em>pfhrp2 </em>and <em>pfhrp3</em> gene deletions in multiple strain infections of <em>Plasmodium... (Publications)
The rapid and accurate diagnosis of Plasmodium falciparum malaria infection is an essential factor in malaria control. Currently, malaria diagnosis in the field depends heavily on using rapid diagnostic [...] blood. P. falciparum strains lacking PfHRP2, due to pfhrp2 gene deletions, are an emerging threat to malaria control programs. The novel assay described here, named qHRP2/3-del, is well suited for high-throughput
Antimalarial efficacy of MMV390048, an inhibitor of <em>Plasmodium</em> phosphatidylinositol 4-kinase (Publications)
of MMV390048 to block all life cycle stages of the malaria parasite suggests that this compound should be further developed and may contribute to malaria control and eradication as part of a single-dose [...] As part of the global effort toward malaria eradication, phenotypic whole-cell screening revealed the 2-aminopyridine class of small molecules as a good starting point to develop new antimalarial drugs [...] we found that the derivative, MMV390048, lacked cross-resistance with current drugs...
Repeated mass distributions and continuous distribution of long-lasting insecticidal nets: modelling sustainability of health benefits from mosquito... (Publications)
LLIN distribution were also examined. METHODS: Dynamic simulations of malaria in humans and mosquitoes were run on the OpenMalaria platform, using stochastic individual-based simulation models. LLINs were [...] BACKGROUND: Stagnating funds for malaria control have spurred interest in the question of how to sustain the gains of recent successes with long-lasting insecticidal nets (LLINs) and improved case management [...] management (CM). This simulation study examined the malaria transmission...
Differential expression of var gene groups is associated with morbidity caused by <em>Plasmodium falciparum </em>infection in Tanzanian children (Publications)
uncomplicated, and asymptomatic malaria. Transcripts of var group A and B genes were more abundant in patients with severe malaria than in patients with uncomplicated malaria. In general, the transcript [...] abundances of var group A and B genes were higher for children with clinical malaria than for children with asymptomatic infections. The var group C and var1-like transcript abundances were similar between
Rapid diagnostic tests for non-malarial febrile illness in the tropics (Publications)
of rapid diagnostic tests (RDTs) for malaria has highlighted the decreasing proportion of malaria-attributable illness in endemic areas. Unfortunately, once malaria is excluded, there are few accessible [...] pressing need for sensitive pathogen-detection-based RDTs, as have been successfully developed for malaria and dengue. Ultimately, integration of RDTs into a validated syndromic approach to tropical fevers
The activities of current antimalarial drugs on the life cycle stages of <em>Plasmodium</em>: a comparative study with human and rodent parasites (Publications)
to alleviate symptoms of malaria in the blood stage. To overcome this critical gap, we developed assays to measure activity of antimalarials against all life stages of malaria parasites, using a diverse [...] BACKGROUND: Malaria remains a disease of devastating global impact, killing more than 800,000 people every year-the vast majority being children under the age of 5. While effective therapies are available [...] available, if malaria is to be eradicated a broader range of small molecule...
Aetiology of fever in returning travelers and migrants: a systematic review and meta-analysis (Publications)
openia and hyperbilirubinemia were respectively 5-14, 3-11 and 5-7 times more likely in malaria than non-malaria patients. High variability of results between studies reflects heterogeneity in study design [...] investigations performed, and diseases included. CONCLUSION: Malaria accounted for one fifth of febrile cases, highlighting the importance of rapid malaria testing in febrile returning travelers, followed by other [...] met criteria for data extraction. Tropical infections accounted for...