Starting at the community: treatment-seeking pathways of children with suspected severe malaria in Uganda (Publications)
than five years with suspected severe malaria. An observational study in Uganda enrolled children below five years presenting to CHWs with signs of severe malaria. Children were followed up 28 days after [...] Community health workers (CHW) usually refer children with suspected severe malaria to the nearest public health facility or a designated public referral health facility (RHF). Caregivers do not always
Risk of imported malaria infections in Zanzibar: a cross-sectional study (Publications)
and the risk of malaria infection, may help to control malaria importation to Zanzibar. METHODS: A rolling cross-sectional survey linked to routine reactive case detection of malaria was carried out in [...] and October 2018. Households of patients diagnosed with malaria at health facilities were surveyed and household members were tested for malaria using rapid diagnostic tests and a sub-sample by quantitative [...] trips within and outside of Zanzibar. We estimated the association of malaria...
Spatio-temporal modelling of routine health facility data for malaria risk micro-stratification in mainland Tanzania (Publications)
probability of malaria TPR exceeding programmatic threshold was estimated. Results showed a marked spatial heterogeneity in malaria TPR across wards. 17.7 million people resided in areas where malaria TPR was [...] As malaria transmission declines, the need to monitor the heterogeneity of malaria risk at finer scales becomes critical to guide community-based targeted interventions. Although routine health facility [...] million people lived in areas where malaria TPR was very low ( < 5%; 90%...
Tafenoquine following G6PD screening versus primaquine for the treatment of vivax malaria in Brazil: a cost-effectiveness analysis using a... (Publications)
most sensitive to severity and mortality due to vivax malaria, the lifetime and number of semiquantitative G6PD analysers needed, cost per malaria episode and per G6PD test strips, and life expectancy [...] BACKGROUND: Malaria transmission modelling has demonstrated the potential impact of semiquantitative glucose-6-phosphate dehydrogenase (G6PD) testing and treatment with single-dose tafenoquine for Plasmodium [...] estimates for low transmission settings, the costs of G6PD screening, and the...
Bridging the gap from molecular surveillance to programmatic decisions for malaria control and elimination (Publications)
An increasing number of molecular and genomic assays are available to study malaria parasite populations. However, so far they have played a marginal role in informing policy and programmatic decision-making [...] the origin of imported infections and characterize transmission chains in settings with very low malaria transmission, and using serology to monitor recent and past exposures in low-transmission settings [...] integrate molecular and genomic data into control program decision-making,...
<em>Plasmodium falciparum</em> merozoite surface protein 1 as asexual blood stage malaria vaccine candidate (Publications)
INTRODUCTION: Malaria represents a tremendous public health challenge in tropical and sub-tropical regions, and currently deployed control strategies are likely insufficient to drive elimination of malaria. Development [...] Development and improvement of malaria vaccines might be key to reduce disease burden. Vaccines targeting asexual blood stages of the parasite have shown limited efficacy when studied in human trials conducted [...] as one of the most promising approaches to provide immune...
Evaluation of malaria rapid diagnostic test performance and <em>pfhrp2</em> deletion in Tanzania school surveys, 2017 (Publications)
As part of malaria nationwide monitoring and evaluation initiatives, there is an increasing trend of incorporating malaria rapid diagnostic tests (mRDTs) in surveys conducted within primary schools to [...] to detect malaria parasites. However, mRDTs based on the detection of histidine-rich protein 2 (HRP2) are known to yield false-positive results due to persistent antigenemia, and false-negative results may
Design and selection of drug properties to increase the public health impact of next-generation seasonal malaria chemoprevention: a modelling study (Publications)
BACKGROUND: Seasonal malaria chemoprevention (SMC) is recommended for disease control in settings with moderate to high Plasmodium falciparum transmission and currently depends on the administration of [...] threaten the effectiveness of SMC. Guidance is needed to de-risk the development of drug compounds for malaria prevention. We aimed to provide guidance for the early prioritisation of new and alternative SMC [...] their target product profiles. METHODS: In this modelling study, we combined...
Correction: Testing and treatment for malaria elimination: a systematic review (Publications)
Correction: Malaria Journal (2023) 22:254 https://doi.org/10.1186/s12936-023-04670-8
Accessibility of malaria commodities in Geita District Council, mainland Tanzania: the experiences from healthcare providers and clients (Publications)
BACKGROUND: Access to essential malaria commodities is a cornerstone in malaria control. However optimal availability and access to essential malaria commodities remain a challenge in Tanzania. Therefore [...] the accessibility, of malaria commodities in private and faith-based health facilities is still sub-optimal. Logistic management needs to be improved to eliminate stockouts and malaria commodities high costs [...] Therefore, this study aimed to explore the factors affecting the...