Should deep-sequenced amplicons become the new gold-standard for analysing malaria drug clinical trials? (Publications)
used to distinguish genotyping 'noise' from real low density signals, the local epidemiology of malaria transmission, and the potential impact of genetic signals from gametocytes. Results. AmpSeq greatly
Spatio-temporal malaria transmission patterns in Navrongo demographic surveillance site, northern Ghana (Publications)
BACKGROUND: The relationship between entomological measures of malaria transmission intensity and mortality remains uncertain. This is partly because transmission is heterogeneous even within small ge [...] analysed data from Kassena-Nankana districts in northern Ghana to obtain small area estimates of malaria transmission rates allowing for this uncertainty.METHODS: Independent Bayesian geostatistical models [...] mosquito densities.CONCLUSION: This study confirms the presence of...
Spatio-temporal analysis of the role of climate in inter-annual variation of malaria incidence in Zimbabwe (Publications)
inter-annual variation in malaria incidence. Quantitative description of the space-time effect of this association has practical implications for the development of operational malaria early warning system [...] system (MEWS) and malaria control. We used Bayesian negative binomial models for spatio-temporal analysis of the relationship between annual malaria incidence and selected climatic covariates at a district level [...] 1988-1999. RESULTS: Considerable inter-annual variations were observed...
Modelling the epidemiological impact of intermittent preventive treatment against malaria in infants (Publications)
preventive treatment against malaria in infants (IPTi) using sulphadoxine-pyrimethamine (SP) have shown a positive, albeit variable, protective efficacy against clinical malaria episodes. The impact of IPTi [...] periods. The predicted cumulative benefits were proportionately slightly greater for severe malaria episodes and malaria-attributable mortality than for acute episodes in the settings modelled. Modest increased [...] mortality. METHODS/PRINCIPAL FINDINGS: We used a comprehensive,...
Epidemiology and clinical features of vivax malaria imported to Europe: sentinel surveillance data from TropNetEurop (Publications)
Plasmodium vivax is the second most common species among malaria patients diagnosed in Europe, but epidemiological and clinical data on imported P. vivax malaria are limited. The TropNetEurop surveillance network [...] network has monitored the importation of vivax malaria into Europe since 1999. OBJECTIVES: To present epidemiological and clinical data on imported P. vivax malaria collected at European level. MATERIAL AND [...] AND METHODS: Data of primary cases of P. vivax malaria reported...
Mapping malaria risk among children in Côte d'Ivoire using Bayesian geo-statistical models (Publications)
estimated 767,000 disability-adjusted life years are due to malaria, placing the country at position number 14 with regard to the global burden of malaria. Risk maps are important to guide control interventions [...] ons, and hence, the aim of this study was to predict the geographical distribution of malaria infection risk in children aged
Potential benefits, limitations and target product-profiles of odor-baited mosquito traps for malaria control in Africa (Publications)
as suitable technologies for controlling malaria and other mosquito-borne diseases. We investigated the potential benefits of such traps for preventing malaria transmission in Africa and the essential [...] users and non-users of insecticide-treated nets (ITNs), currently the primary malaria prevention method. We determined that malaria transmission declines as trap coverage (proportion of total availability of [...] match the impact of 50% community-wide ITN coverage. If such traps are used to...
Estimating the burden of malaria: the need for improved surveillance (Publications)
the importance of using complementary methods to estimate the burden of malaria and call for a renewed focus on efficient malaria surveillance