Vaccines against malaria: perspectives from Papua New Guinea (Publications)
perspectives on malaria vaccines. Building on a long history of malaria research, in this article we review past achievements, highlight current research and outline future directions in malaria vaccine research [...] transmission of all four species of human malaria, a full range of malaria endemicities, well described epidemiology and a demonstrated capacity to evaluate a malaria vaccine, PNG currently has the only field [...] Despite its small population and isolated location Papua New Guinea...
<em>In vitro</em> screening of traditional South African malaria remedies against <em>Trypanosoma brucei rhodesiense</em>, <em>Trypanosoma cruzi,... (Publications)
Three hundred extracts were prepared from plants traditionally used in South Africa to treat malaria and screened IN VITRO for activity against TRYPANOSOMA BRUCEI RHODESIENSE, TRYPANOSOMA CRUZI, LEISHMANIA
Socially marketed insecticide-treated nets improve malaria and anaemia in pregnancy in southern Tanzania (Publications)
CONCLUSIONS: A modest impact of ITNs on pregnancy malaria and anaemia was shown in our high malaria transmission setting. The development of ITN programmes for malaria control should include pregnant women as a [...] no anaemia, and of high density, low density and no malaria infection by ITN status. Recently treated nets were most effective at preventing malaria and anaemia (prevalence of mild anaemia was 68% compared [...] OBJECTIVES: To study the uptake of socially marketed...
Environmental predictors of the seasonality of malaria transmission in Africa: the challenge (Publications)
A description of malaria seasonality is important for planning and optimizing malaria control in both time and space, but adequate malariologic data are not available for many disease-endemic areas. We [...] between the seasonal dynamics of environmental determinants and malaria pose a great challenge and highlights the need for improved models of malaria seasonality
Effect of malaria on soluble transferrin receptor levels in Tanzanian infants (Publications)
iron deficiency in malaria endemic areas remains unresolved. Three hundred and fourteen infants in a rural area of southern Tanzania living under conditions of intense and perennial malaria transmission were [...] The diagnosis of iron deficiency anemia in malaria endemic areas is complicated by the influence of the infection on the laboratory tests conventionally used to assess iron status. Determination of soluble [...] plasma levels in the assessment of iron deficiency anemia. Independent of...
Structure-activity-based design of a synthetic malaria peptide eliciting sporozoite inhibitory antibodies in a virosomal formulation (Publications)
ozoite protein (CSP) of Plasmodium falciparum is a leading candidate antigen for inclusion in a malaria subunit vaccine. We describe here the design of a conformationally constrained synthetic peptide
The sensitivity of the OptiMAL rapid diagnostic test to the presence of <em>Plasmodium falciparum </em>gametocytes compromises its ability to monitor... (Publications)
Using in vivo samples from treatment failure malaria cases, we demonstrate the high sensitivity of the parasite lactase dehydrogenase (pLDH)-based OptiMAL rapid diagnostic test in the detection of P.