Tests diagnostiques rapides (TDR): la panacée pour le praticien? (Publications)
implementing a sequential diagnostic strategy to avoid extensive investigations. Using the example of malaria, a new strategy that includes a RDT as first-line emergency diagnostic tool and, when negative, delayed
Quinuclidine derivatives as potential antiparasitics (Publications)
causative organism of human African trypanosomiasis) and Plasmodium falciparum (a causative agent of malaria), but through an unknown mode(s) of action
QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids (Publications)
pharmacologic properties make them suitable lead structures for new agents, in particular against malaria. Since these natural products are not easy to isolate in sufficient quantities or to synthesize
Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the <em>Plasmodium falciparum</em> dUTPase (Publications)
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for malaria. We previously reported some 5'-tritylated deoxyuridine analogues (both cyclic and acyclic) as selective
Immunoglobulin kappa light-chain V, J, and C gene sequences of the owl monkey <em>Aotus nancymaae</em> (Publications)
supports the proposal to use the Aotus Plasmodium falciparum infection model for the evaluation of malaria vaccine candidates
Structure-activity relationship studies of pyrrolone antimalarial agents (Publications)
mammalian (L6) cells. Three representative compounds were selected for evaluation in a rodent model of malaria infection, and the best compound showed improved ability to decrease parasitaemia and a slight increase
Costs and cost-effectiveness of <em>Plasmodium vivax </em>control (Publications)
The continued success of efforts to reduce the global malaria burden will require sustained funding for interventions specifically targeting Plasmodium vivax The optimal use of limited financial resources
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: part 2 (Publications)
for antiplasmodial activity against NF54 (sensitive) and K1 (multidrug resistant) strains of the malaria parasite Plasmodium falciparum and evaluated for both aqueous solubility and metabolic stability
Trypanocidal activity of diarylheptanoids from <em>Schrankia leptocarpa</em> DC (Publications)
Schrankia leptocara is a medicinal species use traditionally in Benin to treat malaria. A previous study showed interesting antimalarial activity against two strains of Plasmodium falciparum. Phytochemical
<em>In silico</em> guided reconstruction and analysis of ICAM-1-binding var genes from <em>Plasmodium falciparum</em> (Publications)
the surface of infected erythrocytes is thought to play a major role in the pathology of severe malaria. As the sequence pool of the var genes encoding PfEMP1 expands there are opportunities, despite the