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1. A genome-wide association study on medulloblastoma (Publications)

   A genome-wide association study on medulloblastoma

   Relevanz:

   INTRODUCTION: Medulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants associated with medulloblastoma risk, we conduct

2. Insights from quantitative and mathematical modelling on the proposed 2030 goal for <em>gambiense </em>human African trypanosomiasis (gHAT) (Publications)

   Insights from quantitative and mathematical modelling on the proposed 2030 goal for <em>gambiense </em>human African trypanosomiasis (gHAT)

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3. Phototemtide A, a cyclic lipopeptide heterologously expressed from<em> Photorhabdus temperata </em>Meg1, shows selective antiprotozoal activity (Publications)

   Phototemtide A, a cyclic lipopeptide heterologously expressed from<em> Photorhabdus temperata </em>Meg1, shows selective antiprotozoal activity

   Relevanz:

   A new cyclic lipopeptide, phototemtide A (1), was isolated from Escherichia coli expressing the biosynthetic gene cluster pttABC from Photorhabdus temperata Meg1. The structure of 1 was elucidated by

4. Preclinical antimalarial combination study of M5717, a <em>Plasmodium falciparum</em> elongation factor 2 inhibitor, and pyronaridine, a hemozoin... (Publications)

   Preclinical antimalarial combination study of M5717, a <em>Plasmodium falciparum</em> elongation factor 2 inhibitor, and pyronaridine, a hemozoin formation inhibitor

   Relevanz:

   Antimalarial drug resistance in the Plasmodium falciparum parasite poses a constant challenge for drug development. To mitigate this risk, new antimalarial medicines should be developed as fixed-dose

5. Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries (Publications)

   Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries

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   OBJECTIVE: To assess short term mortality risks and excess mortality associated with exposure to ozone in several cities worldwide. DESIGN: Two stage time series analysis. SETTING: 406 cities in 20 co

6. Challenges for HIV-infected adolescents during transition from paediatric to adult HIV clinics in Africa (Publications)

   Challenges for HIV-infected adolescents during transition from paediatric to adult HIV clinics in Africa

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7. Towards protective immune responses against malaria in pregnant women (Publications)

   Towards protective immune responses against malaria in pregnant women

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8. Malaria elimination transmission and costing in the Asia-Pacific: developing an investment case (Publications)

   Malaria elimination transmission and costing in the Asia-Pacific: developing an investment case

   Relevanz:

   Background: The Asia-Pacific region has made significant progress against malaria, reducing cases and deaths by over 50% between 2010 and 2015. These gains have been facilitated in part, by strong pol

9. TNF-α antagonists differentially induce TGF-β1-dependent resuscitation of dormant-like <em>Mycobacterium tuberculosis</em> (Publications)

   TNF-α antagonists differentially induce TGF-β1-dependent resuscitation of dormant-like <em>Mycobacterium tuberculosis</em>

   Relevanz:

   TNF-alpha- as well as non-TNF-alpha-targeting biologics are prescribed to treat a variety of immune-mediated inflammatory disorders. The well-documented risk of tuberculosis progression associated wit

10. The fight against lymphatic filariasis: perceptions of community drug distributors during mass drug administration in coastal Kenya (Publications)

    The fight against lymphatic filariasis: perceptions of community drug distributors during mass drug administration in coastal Kenya

    Relevanz:

    BACKGROUND: Lymphatic filariasis (LF), a neglected tropical disease (NTD) and leading cause of global disability, is endemic in 32 countries in Africa with almost 350 million people requiring regular