Generation of aurachin derivatives by whole-cell biotransformation and evaluation of their antiprotozoal properties (Publications)
The natural product aurachin D is a farnesylated quinolone alkaloid, which is known to possess activity against the causative agent of malaria, Plasmodium spp. In this study, we show that aurachin D i
Diagnosis of helminths depends on worm fecundity and the distribution of parasites within hosts (Publications)
Helminth transmission and morbidity are dependent on the number of mature parasites within a host; however, observing adult worms is impossible for many natural infections. An outstanding challenge is
Modeling marine cargo traffic to identify countries in Africa with greatest risk of invasion by <em>Anopheles stephensi</em> (Publications)
Anopheles stephensi, an invasive malaria vector native to South Asia and the Arabian Peninsula, was detected in Djibouti's seaport, followed by Ethiopia, Sudan, Somalia, and Nigeria. If An. stephensi
How to scale-up: a comparative case study of scaling up a district health management strengthening intervention in Ghana, Malawi and Uganda (Publications)
BACKGROUND: The need to scale up public health interventions in low- and middle-income countries to ensure equitable and sustainable impact is widely acknowledged. However, there has been little under
The importance of the treatment rationale for pain in animal-assisted interventions: a randomized controlled trial in healthy participants (Publications)
Animal-assisted interventions (AAIs) is a promising treatment approach for pain, but possible mechanisms still need to be elucidated. This study set out to investigate the analgesic effects of an anim
Stigma-directed services (Stig2Health) to improve 'linkage to care' for people living with HIV in rural Tanzania: study protocol for a nested pre-post... (Publications)
Background: HIV-related stigma is a major barrier to the timely linkage and retention of patients in HIV care in sub-Saharan Africa, where most people living with HIV/AIDS reside. In this implementati
Perceived water-related risk factors of Buruli ulcer in two villages of south-central Côte d’Ivoire (Publications)
Background Buruli ulcer, caused by Mycobacterium ulcerans, is a neglected tropical skin disease that is primarily endemic in West and Central Africa, including Côte d’Ivoire. Studies indicate that M.
Long-term exposure to traffic-related air pollution and stroke: a systematic review and meta-analysis (Publications)
Background Stroke remains the second cause of death worldwide. The mechanisms underlying the adverse association of exposure to traffic-related air pollution (TRAP) with overall cardiovascular disease
Care cascades for hypertension and diabetes: cross-sectional evaluation of rural districts in Tanzania (Publications)
BACKGROUND: Noncommunicable diseases (NCDs), especially hypertension and diabetes, are rapidly rising in sub-Saharan Africa, necessitating health systems transformations. In Tanzania, current policies
Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased... (Publications)
BACKGROUND: While prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to mal
