Prevalence of airflow obstruction in smokers and never smokers in Switzerland (Publications)
We aimed to measure age-specific prevalence of airflow obstruction (AO) in Switzerland in smokers and never smokers using pulmonary function tests and respiratory symptoms from 6126 subjects participa
Alternative application of melarsoprol for treatment of <em>T.b. gambiense</em> sleeping sickness: preliminary results (Publications)
The protocols for treatment of human African trypanosomiasis (sleeping sickness) with the organoarsenical drug melarsoprol are based on empirical observations. Therapy is often accompanied by serious
Long-term decline in lung function, utilisation of care and quality of life in modified GOLD stage 1 COPD (Publications)
BACKGROUND: Little is known about the long-term outcomes of individuals with mild chronic obstructive pulmonary disease (COPD) as defined by the Global Initiative for Chronic Obstructive Lung Disease
Novel <em>in vivo</em> active anti-malarials based on a hydroxy-ethyl-amine scaffold (Publications)
A novel series of anti-malarials, based on a hydroxy-ethyl-amine scaffold, initially identified as peptidomimetic protease inhibitors is described. Combination of the hydroxy-ethyl-amine anti-malarial
Whole-genome sequencing of rifampicin-resistant <em>Mycobacterium tuberculosis</em> strains identifies compensatory mutations in RNA polymerase genes (Publications)
Epidemics of drug-resistant bacteria emerge worldwide, even as resistant strains frequently have reduced fitness compared to their drug-susceptible counterparts. Data from model systems suggest that t
Approach to estimating participant pollutant exposures in the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) (Publications)
Most published epidemiology studies of long-term air pollution health effects have relied on central site monitoring to investigate regional-scale differences in exposure. Few cohort studies have had
The effect of cyclin D1 (CCND1) G870A-polymorphism on breast cancer risk is modified by oxidative stress among Chinese women in Singapore (Publications)
Cyclin D1 (CCND1), an intracellular cell-cycle regulatory protein with checkpoint function, can promote cell proliferation or induce growth arrest and apoptosis depending on the cellular context. We h
