Cynaropicrin targets the trypanothione redox system in <em>Trypanosoma brucei</em> (Publications)
In mice cynaropicrin (CYN) potently inhibits the proliferation of Trypanosoma brucei-the causative agent of Human African Trypanosomiasis-by a so far unknown mechanism. We hypothesized that CYNs ?,?-u
A primaquine-chloroquine hybrid with dual activity against <em>Plasmodium</em> liver and blood stages (Publications)
We present a new class of hybrid molecules consisting of the established antiplasmodial drugs primaquine and chloroquine. No drug is known to date that acts comparably against all stages of Plasmodium
Characterization of choline uptake in<em> Trypanosoma brucei</em> procyclic and bloodstream forms (Publications)
Choline is an essential nutrient for eukaryotic cells, where it is used as precursor for the synthesis of choline-containing phospholipids, such as phosphatidylcholine (PC). According to published dat
Mobile phone use and the risk of skin cancer: a nationwide cohort study in Denmark (Publications)
The International Agency for Research on Cancer has classified radiofrequency radiation as possibly carcinogenic. Previous studies have focused on intracranial tumors, although the skin receives much
Generation of chimeric monoclonal antibodies from mice that carry human immunoglobulin Cgamma1 heavy of Ckappa light chain gene segments (Publications)
Gene targeting in mouse embryonic stem (ES) cells was used to replace (i) the mouse immunoglobulin heavy chain (IgH) Cgamma2a gene segment (mCgamma2a) with the human Cgamma1 gene segment (hCgamma1), a
<em>Plasmodium falciparum</em> protein kinase 5 and the malarial nuclear division cycles (Publications)
In the course of our studies on cell cycle regulation mechanisms of Plasmodium falciparum, we investigated expression pattern, kinase activity, and localization of PfPK5, a putative malarial member of
Psychiatric disorders, suicidality, and personality among young men by sexual orientation (Publications)
Personality and its potential role in mediating risk of psychiatric disorders and suicidality are assessed by sexual orientation, using data collected among young Swiss men (n=5875) recruited while pr
Heterochromatin protein 1 secures survival and transmission of malaria parasites (Publications)
Clonally variant expression of surface antigens allows the malaria parasite Plasmodium falciparum to evade immune recognition during blood stage infection and secure malaria transmission. We demonstra
Application of the enzyme-linked immunosorbent assay (ELISA) for the diagnosis of filariasis and echinococcosis (Publications)
The Enzyme-Linked Immunosorbent Assay (ELISA) was compared with the Indirect Fluorescent Antibody Test (IFAT), the Indirect Haemagglutination Test (IHA) and Counter Immuno Electrophoresis (CIE) in the
