Antibody-mediated neutralization of the exotoxin mycolactone, the main virulence factor produced by <em>Mycobacterium ulcerans</em> (Publications)
BACKGROUND: Mycolactone, the macrolide exotoxin produced by Mycobacterium ulcerans, causes extensive tissue destruction by inducing apoptosis of host cells. In this study, we aimed at the production o
Non-vector-borne transmission of Zika virus: a systematic review (Publications)
BACKGROUND: Increasing numbers of confirmed cases of Zika virus (ZIKV) infection resulting from non-mosquito-borne transmission have been reported. METHODS: We performed a systematic literature review
Evaluation of malaria diagnoses using a handheld light microscope in a community-based setting in rural Côte d'Ivoire (Publications)
Portable microscopy may facilitate quality diagnostic care in resource-constrained settings. We compared a handheld light microscope (Newton Nm1) with a mobile phone attachment to conventional light m
Comparison of sensitivity and faecal egg counts of mini-FLOTAC using fixed stool samples and Kato-Katz technique for the diagnosis of <em>Schistosoma... (Publications)
Accurate diagnostic tools for human helminthiasis are crucial for improved patient management and evaluation of community-based intervention studies. However, the diagnosis of intestinal schistosomias
Regular family breakfast was associated with children's overweight and parental education: results from the ENERGY cross-sectional study (Publications)
INTRODUCTION: This study aims to assess (i) the prevalence of having regular family breakfast, lunch, dinner (i.e. 5-7days/week together with their family) among 10-12year olds in Europe, (ii) the ass
Discovery and characterization of ACT-451840: an antimalarial drug with a novel mechanism of action (Publications)
More than 40 % of the world's population is at risk of being infected with malaria. Most malaria cases occur in the countries of sub-Saharan Africa, Central and South America, and Asia. Resistance to
Correcting India's chronic shortage of drug inspectors to ensure the production and distribution of safe, high-quality medicines (Publications)
BACKGROUND: Good drug regulation requires an effective system for monitoring and inspection of manufacturing and sales units. In India, despite widespread agreement on this principle, ongoing shortage
Characterization of novel antimalarial compound ACT-451840: preclinical assessment of activity and dose-efficacy modeling (Publications)
BACKGROUND: Artemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of
Incidence and risk factors for hypertension among HIV patients in rural Tanzania - a prospective cohort study (Publications)
INTRODUCTION: Scarce data are available on the epidemiology of hypertension among HIV patients in rural sub-Saharan Africa. We explored the prevalence, incidence and risk factors for incident hyperten
