The global progress of soil-transmitted helminthiases control in 2020 and World Health Organization targets for 2030 (Publications)
Soil-transmitted helminth (STH) infections are the most widespread of the neglected tropical diseases, primarily affecting marginalized populations in low- and middle-income countries. More than one b
Clinical data combined with modelling and simulation indicate unchanged drug-drug interaction magnitudes in the elderly (Publications)
Age-related comorbidities and consequently polypharmacy are highly prevalent in the elderly, resulting in an increased risk for drug-drug interactions (DDIs). The effect of aging on DDI magnitudes is
Incidence of depression in relation to transportation noise exposure and noise annoyance in the SAPALDIA study (Publications)
Prospective evidence on the risk of depression in relation to transportation noise exposure and noise annoyance is limited and mixed. We aimed to investigate the associations of long-term exposure to
Informed consent approaches for clinical trial participation of infants with minor parents in sub-Saharan Africa: a systematic review (Publications)
BACKGROUND: Regulations are vague regarding the appropriate decision-maker and authority to consent for children of minor parents participating in clinical trials. In countries with high rates of unde
(+/-)-<em>trans</em>-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents: synthesis, <em>in vitro</em> evaluation and SAR analysis (Publications)
Leishmaniasis, a neglected tropical disease caused by parasites of the genus Leishmania, causes a serious burden of disease around the world, represents a threat to the life of millions of people, and
Seasonality of suicide: a multi-country multi-community observational study (Publications)
AIMS: We aimed to investigate the heterogeneity of seasonal suicide patterns among multiple geographically, demographically and socioeconomically diverse populations. METHODS: Weekly time-series data
Accuracy of different diagnostic techniques for <em>Schistosoma haematobium</em> to estimate treatment needs in Zimbabwe: application of a... (Publications)
BACKGROUND: Treatment needs for Schistosoma haematobium are commonly evaluated using urine filtration with detection of parasite eggs under a microscope. A common symptom of S. haematobium is hematuri
Evaluation of seasonal malaria chemoprevention in two areas of intense seasonal malaria transmission: secondary analysis of a household-randomised,... (Publications)
BACKGROUND: Seasonal malaria chemoprevention (SMC) is now widely deployed in the Sahel, including several countries that are major contributors to the global burden of malaria. Consequently, it is imp
Medicinal chemistry optimization of a diaminopurine chemotype: toward a lead for <em>Trypanosoma brucei</em> inhibitors (Publications)
Human African trypanosomiasis (HAT), or sleeping sickness, is caused by the protozoan parasite Trypanosoma brucei and transmitted through the bite of infected tsetse flies. The disease is considered f
