Publications

Chakhaia T, Blumberg H.M, Kempker R.R, Luo R, Dzidzikashvili N, Chincharauli M, Tukvadze N, Avaliani Z, Stauber C, Magee M.J. Lack of weight gain and increased mortality during and after treatment among adults with drug-resistant tuberculosis: a retrospective cohort study in Georgia, 2009-2020. ERJ Open Res. 2025;11(3):00839-2024. DOI: 10.1183/23120541.00839-2024

Collins J.M, Bobosha K, Narayanan N, Gandhi N.R, Day C.L, Rengarajan J, Kempker R.R, Lau M.S.Y, Nellis M, Tukvadze N, Shah N.S, Brust J.C.M, Nizam A, Ismail N.A, Kauffman K.D, Sakai S, Jones D.P, Barber D.L, Ziegler T.R, Ernst J.D, Blumberg H.M, Wassie L, TBRU-ASTRa Study Group. A plasma metabolic signature to diagnose pulmonary tuberculosis and monitor treatment response. J Infect Dis. 2025(in press). DOI: 10.1093/infdis/jiaf240

Goig G.A, Loiseau C, Maghradze N, McHedlishvili K, Avaliani T, Brites D, Borrell S, Aspindzelashvili R, Avaliani Z, Kipiani M, Tukvadze N, Jugheli L, Gagneux S. Transmission as a key driver of resistance to the new tuberculosis drugs. N Engl J Med. 2025;392(1):97-99. DOI: 10.1056/NEJMc2404644

March V.F.A, Maghradze N, McHedlishvili K, Avaliani T, Aspindzelashvili R, Avaliani Z, Kipiani M, Tukvadze N, Jugheli L, Bouaouina S, Doetsch A, Goig G.A, Gagneux S, Borrell S. Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis. Sci Rep. 2025;15:3588. DOI: 10.1038/s41598-024-85092-7

Pfurtscheller T, Tsutsunava A, Maghradze N, Gujabidze M, Bablishvili N, Yerlikaya S, Denkinger C.M, Tukvadze N, Gupta-Wright A. Programmatic diagnostic accuracy and clinical utility of Xpert MTB/XDR in patients with rifampicin-resistant tuberculosis in Georgia. Open Forum Infect Dis. 2025;12(2):ofaf022. DOI: 10.1093/ofid/ofaf022

Tukvadze N, Mashatole S, Jacobs A, Ngwanto T, Heinrich N, Van Rie A, Crudu V, Tudor E, Goginashvili L, Ibraim E, Khosa C, Howell P, Rajaram S, Naidoo K, Niemann S, Reither K, Wallis R.S. DRTB-HDT: a randomized controlled trial of two adjunctive host-directed therapies in rifampin-resistant tuberculosis. BMC Infect Dis. 2025;25:768. DOI: 10.1186/s12879-025-11072-5

Buziashvili M, Djibuti M, Tukvadze N, DeHovitz J, Baliashvili D. Incidence rate and risk factors for developing active tuberculosis among people living with HIV in Georgia 2019-2020 cohort. Open Forum Infect Dis. 2024;11(9):ofae466. DOI: 10.1093/ofid/ofae466

Cirillo D, Anthony R, Gagneux S, Horsburgh C.R. Jr, Hasan R, Darboe S, Laniado-Laborin R, Probandari A, Tukvadze N, Arcêncio R.A, Bimba J.S, Brighenti S, Chesov D, Chiang C.Y, Kalmambetova G, Knight G, Konstantynovska O, Kruse A, Lange C, Mayanja-Kizza H, McBryde E, Min J, Sanchez-Montalva A, Sulis G, Tsogt B, van der Walt M, Yeboah-Manu D, Hauser J. A successful UN High-Level Meeting on antimicrobial resistance must build on the 2023 UN High-Level Meeting on tuberculosis. Lancet Glob Health. 2024;12(8):e1225-e1226. DOI: 10.1016/s2214-109x(24)00229-8

Salindri A.D, Kipiani M, Lomtadze N, Tukvadze N, Avaliani Z, Blumberg H.M, Masyn K.E, Rothenberg R.B, Kempker R.R, Magee M.J. HIV co-infection increases the risk of post-tuberculosis mortality among persons who initiated treatment for drug-resistant tuberculosis. Sci Rep. 2024;14:23834. DOI: 10.1038/s41598-024-68605-2

Loiseau C, Windels E.M, Gygli S.M, Jugheli L, Maghradze N, Brites D, Ross A, Goig G, Reinhard M, Borrell S, Trauner A, Dötsch A, Aspindzelashvili R, Denes R, Reither K, Beisel C, Tukvadze N, Avaliani Z, Stadler T, Gagneux S. The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot. Nat Commun. 2023;14:1988. DOI: 10.1038/s41467-023-37719-y

Maghradze N, Jugheli L, Borrell S, Tukvadze N, Kempker R.R, Blumberg H.M, Gagneux S. Developing customized stepwise MIRU-VNTR typing for tuberculosis surveillance in Georgia. PLoS One. 2022;17(3):e0264472. DOI: 10.1371/journal.pone.0264472

Gygli S.M, Loiseau C, Jugheli L, Adamia N, Trauner A, Reinhard M, Ross A, Borrell S, Aspindzelashvili R, Maghradze N, Reither K, Beisel C, Tukvadze N, Avaliani Z, Gagneux S. Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis. Nat Med. 2021;27:1171–1177. DOI: 10.1038/s41591-021-01358-x

Gygli S.M, Loiseau C, Jugheli L, Adamia N, Trauner A, Reinhard M, Ross A, Borrell S, Aspindzelashvili R, Maghradze N, Reither K, Beisel C, Tukvadze N, Avaliani Z, Gagneux S. Publisher Correction: Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis. Nat Med. 2021;27(7):1308. DOI: 10.1038/s41591-021-01417-3