Publications

Hofmann D, Sayasone S, Sengngam K, Chongvilay B, Hattendorf J, Keiser J. Efficacy and safety of ascending doses of moxidectin against Strongyloides stercoralis infections in adults: a randomised, parallel-group, single-blinded, placebo-controlled, dose-ranging, phase 2a trial. Lancet Infect Dis. 2021;21(8):1151-1160. DOI: 10.1016/S1473-3099(20)30691-5

Jittamala P, Monteiro W, Smit M.R, Pedrique B, Specht S, Chaccour C.J, Dard C, Del Giudice P, Khieu V, Maruani A, Failoc-Rojas V.E, Saez-de-Ocariz M, Soriano-Arandes A, Piquero-Casals J, Faisant A, Brenier-Pinchart M.P, Wimmersberger D, Coulibaly J.T, Keiser J, Boralevi F, Sokana O, Marks M, Engelman D, Romani L, Steer A.C, von Seidlein L, White N.J, Harriss E, Stepniewska K, Humphreys G.S, Kennon K, Guerin P.J, Kobylinski K.C. A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: is it time to reconsider the current contraindication?. PLoS Negl Trop Dis. 2021;15(3):e0009144. DOI: 10.1371/journal.pntd.0009144

Keiser J, Häberli C. Evaluation of commercially available anthelminthics in laboratory models of human intestinal nematode infections. ACS Infect Dis. 2021;7(5):1177-1185. DOI: 10.1021/acsinfecdis.0c00719

Keiser J, Häberli C. Assessment of FDA-approved drugs against Strongyloides ratti in vitro and in vivo to identify potentially active drugs against strongyloidiasis. Parasit Vectors. 2021;14:615. DOI: 10.1186/s13071-021-05117-2

Keller L, Hürlimann E, Patel C, Welsche S, Sayasone S, Ali S.M, Ame S.M, Coulibaly J.T, Keiser J. Insights gained from conductinga randomised controlled trial onIvermectin-albendazole against Trichuris trichiura in Côte d’Ivoire, Lao PDR and Pemba Island. Adv Parasitol. 2021;111:253-276. DOI: 10.1016/bs.apar.2020.11.001

Keller L, Welsche S, Patel C, Sayasone S, Ali S.M, Ame S.M, Hattendorf J, Hürlimann E, Keiser J. Long-term outcomes of ivermectin-albendazole versus albendazole alone against soil-transmitted helminths: results from randomized controlled trials in Lao PDR and Pemba Island, Tanzania. PLoS Negl Trop Dis. 2021;15(6):e0009561. DOI: 10.1371/journal.pntd.0009561

Krücken J, Holden-Dye L, Keiser J, Prichard R.K, Townson S, Makepeace B.L, Hubner M.P, Hahnel S.R, Scandale I, Harder A, Kulke D. Development of emodepside as a possible adulticidal treatment for human onchocerciasis-the fruit of a successful industrial-academic collaboration. PLoS Pathog. 2021;17(7):e1009682. DOI: 10.1371/journal.ppat.1009682

Lombardo F.C, Ravaynia P.S, Modena M.M, Hierlemann A, Keiser J. Evaluation of human liver microtissues for drug screening on Schistosoma mansoni schistosomula. ACS Infect Dis. 2021;7(7):1894-1900. DOI: 10.1021/acsinfecdis.0c00614

Nguyen W, Lee E.F, Evangelista M, Lee M, Harris T.J, Colman P.M, Smith N.A, Williams L.B, Jarman K.E, Lowes K.N, Häberli C, Keiser J, Smith B.J, Fairlie W.D, Sleebs B.E. Optimization of benzothiazole and thiazole hydrazones as inhibitors of schistosome bcl-2a. ACS Infect Dis. 2021;7(5):1143-1163. DOI: 10.1021/acsinfecdis.0c00700

Palmeirim M.S, Mohammed U.A, Ross A, Ame S.M, Ali S.M, Keiser J. Evaluation of two communication tools, slideshow and theater, to improve participants' understanding of a clinical trial in the informed consent procedure on Pemba Island, Tanzania. PLoS Negl Trop Dis. 2021;15(5):e0009409. DOI: 10.1371/journal.pntd.0009409

Palmeirim M.S, Mrimi E.C, Minja E.G, Samson A.J, Keiser J. A cross-sectional survey on parasitic infections in schoolchildren in a rural Tanzanian community. Acta Trop. 2021;213:105737. DOI: 10.1016/j.actatropica.2020.105737

Palmeirim M.S, Specht S, Scandale I, Gander-Meisterernst I, Chabicovsky M, Keiser J. Preclinical and clinical characteristics of the trichuricidal drug oxantel pamoate and clinical development plans: a review. Drugs. 2021;81(8):907-921. DOI: 10.1007/s40265-021-01505-1

Partridge F.A, Bataille C.J.R, Forman R, Marriott A.E, Forde-Thomas J, Häberli C, Dinsdale R.L, O'Sullivan J.D.B, Willis N.J, Wynne G.M, Whiteland H, Archer J, Steven A, Keiser J, Turner J.D, Hoffmann K.F, Taylor M.J, Else K.J, Russell A.J, Sattelle D.B. Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni. ACS Infect Dis. 2021;7(5):1260-1274. DOI: 10.1021/acsinfecdis.1c00025

Patel C, Coulibaly J.T, Hofmann D, N'Gbesso Y, Hattendorf J, Keiser J. Efficacy and safety of albendazole in hookworm-infected preschool-aged children, school-aged children and adults in Côte d'Ivoire: a phase II randomized controlled dose-finding trial. Clin Infect Dis. 2021;73(2):e494-e502. DOI: 10.1093/cid/ciaa989

Patel C, Keller L, Welsche S, Hattendorf J, Sayasone S, Ali S.M, Ame S.M, Coulibaly J.T, Hürlimann E, Keiser J. Assessment of fecal calprotectin and fecal occult blood as point-of-care markers for soil-transmitted helminth attributable intestinal morbidity in a case-control substudy conducted in Côte d'Ivoire, Lao PDR and Pemba Island, Tanzania. EClinicalMedicine. 2021;32:100724. DOI: 10.1016/j.eclinm.2021.100724

Probst A, Chisanga K, Dziwornu G.A, Häberli C, Keiser J, Chibale K. Expanding the activity profile of pyrido[1,2-a]benzimidazoles: synthesis and evaluation of novel n(1)-1-phenylethanamine derivatives against Schistosoma mansoni. ACS Infect Dis. 2021;7(5):1032-1043. DOI: 10.1021/acsinfecdis.0c00278

Probst A, Pujol E, Häberli C, Keiser J, Vázquez S. In vitro, in vivo, and ADME evaluation of SF5-containing N,N'-diarylureas as antischistosomal agents. Antimicrob Agents Chemother. 2021;65(10):e0061521. DOI: 10.1128/aac.00615-21

Sirak B, Asres K, Hailu A, Dube M, Arnold N, Häberli C, Keiser J, Imming P. In vitro antileishmanial and antischistosomal activities of anemonin isolated from the fresh leaves of Ranunculus multifidus forsk. Molecules. 2021;26(24):7473. DOI: 10.3390/molecules26247473

Sy I, Margardt L, Ngbede E.O, Adah M.I, Yusuf S.T, Keiser J, Rehner J, Utzinger J, Poppert S, Becker S.L. Identification of adult Fasciola spp. using matrix-assisted laser/desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. Microorganisms. 2021;9:82. DOI: 10.3390/microorganisms9010082

Walker M, Cools P, Albonico M, Ame S.M, Ayana M, Dana D, Keiser J, Matoso L.F, Montresor A, Mekonnen Z, Corrêa-Oliveira R, Pinto S.A, Sayasone S, Vercruysse J, Vlaminck J, Levecke B. Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure. PLoS Negl Trop Dis. 2021;15(10):e0009888. DOI: 10.1371/journal.pntd.0009888

Welsche S, Mrimi E.C, Keller L, Hürlimann E, Hofmann D, Hattendorf J, Ali S.M, Keiser J. Efficacy and safety of moxidectin and albendazole compared to ivermectin and albendazole co-administration in adolescents infected with Trichuris trichiura: a randomized controlled trial protocol. Gates Open Res. 2021;5:106. DOI: 10.12688/gatesopenres.13299.2

Barda B, Schindler C, Wampfler R, Ame S, Ali S.M, Keiser J. Comparison of real-time PCR and the Kato-Katz method for the diagnosis of soil-transmitted helminthiasis and assessment of cure in a randomized controlled trial. BMC Microbiol. 2020;20:298. DOI: 10.1186/s12866-020-01963-9

Buchter V, Ong Y.C, Mouvet F, Ladaycia A, Lepeltier E, Rothlisberger U, Keiser J, Gasser G. Multidisciplinary preclinical investigations on three oxamniquine analogues as novel drug candidates for schistosomiasis. Chemistry. 2020;26:15232 –15241. DOI: 10.1002/chem.202002856

Buchter V, Priotti J, Leonardi D, Lamas M.C, Keiser J. Preparation, physicochemical characterization and in vitro and in vivo activity against Heligmosomoides polygyrus of novel oral formulations of albendazole and mebendazole. J Pharm Sci. 2020;109(5):1819-1826. DOI: 10.1016/j.xphs.2020.02.002

Buchter V, Priotti J, Leonardi D, Lamas M.C, Keiser J. Activity of novel oral formulations of albendazole and mebendazole against Heligmosomoides polygyrus in vitro and in vivo. J Pharm Sci. 2020;109(5):1819-1826. DOI: 10.1016/j.xphs.2020.02.002

De Rycker M, Horn D, Aldridge B, Amewu R.K, Barry C.E, Buckner F.S, Cook S, Ferguson M.A.J, Gobeau N, Herrmann J, Herrling P, Hope W, Keiser J, Lafuente-Monasterio M.J, Leeson P.D, Leroy D, Manjunatha U.H, McCarthy J, Miles T.J, Mizrahi V, Moshynets O, Niles J, Overington J.P, Pottage J, Rao S.P.S, Read K.D, Ribeiro I, Silver L.L, Southern J, Spangenberg T, Sundar S, Taylor C, Van Voorhis W, White N.J, Wyllie S, Wyatt P.G, Gilbert I.H. Setting our sights on infectious diseases. ACS Infect Dis. 2020;6(1):3-13. DOI: 10.1021/acsinfecdis.9b00371

Else K.J, Keiser J, Holland C.V, Grencis R.K, Sattelle D.B, Fujiwara R.T, Bueno L.L, Asaolu S.O, Sowemimo O.A, Cooper P.J. Whipworm and roundworm infections. Nat Rev Dis Primers. 2020;6(1):44. DOI: 10.1038/s41572-020-0171-3

Keiser J, Koch V, Deckers A, Cheung H.T.A, Jung N, Brase S. Naturally occurring cardenolides affecting Schistosoma mansoni. ACS Infect Dis. 2020;6(7):1922-1927. DOI: 10.1021/acsinfecdis.0c00175

Keller L, Palmeirim M.S, Ame S.M, Ali S.M, Puchkov M, Huwyler J, Hattendorf J, Keiser J. Efficacy and safety of ascending dosages of moxidectin and moxidectin-albendazole against Trichuris trichiura in adolescents: a randomized controlled trial. Clin Infect Dis. 2020;70(6):1193-1201. DOI: 10.1093/cid/ciz326

Keller L, Patel C, Welsche S, Schindler T, Hürlimann E, Keiser J. Performance of the Kato-Katz method and real time polymerase chain reaction for the diagnosis of soil-transmitted helminthiasis in the framework of a randomised controlled trial: treatment efficacy and day-to-day variation. Parasit Vectors. 2020;13:517. DOI: 10.1186/s13071-020-04401-x

Levecke B, Cools P, Albonico M, Ame S, Angebault C, Ayana M, Behnke J.M, Bethony J.M, Cringoli G, Dana D, Guillard B, Viet Hoa N.T, Kang G, Kattula D, Keiser J, Kotze A.C, Matoso L.F, Maurelli M.P, McCarthy J.S, Mekonnen Z, Mirams G, Montresor A, Oliveira R.C, Periago M.V, Pinto S.A, Rinaldi L, Sayasone S, Sumo L, Tchuem-Tchuenté L.A, Cam Thach D.T, Thomas E, Zeynudin A, Verweij J.J, Vlaminck J, Vercruysse J. Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR. PLoS Negl Trop Dis. 2020;14(7):e0008296. DOI: 10.1371/journal.pntd.0008296

Lin Y, Ong Y.C, Keller S, Karges J, Bouchene R, Manoury E, Blacque O, Müller J, Anghel N, Hemphill A, Häberli C, Taki A.C, Gasser R.B, Cariou K, Keiser J, Gasser G. Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole. Dalton Trans. 2020;49(20):6616-6626. DOI: 10.1039/d0dt01107j

Moser W, Keiser J, Speich B, Sayasone S, Knopp S, Hattendorf J. One mean to rule them all? The arithmetic mean based egg reduction rate can be misleading when estimating anthelminthic drug efficacy in clinical trials. PLoS Negl Trop Dis. 2020;14(4):e0008185. DOI: 10.1371/journal.pntd.0008185

Olliaro P.L, Coulibaly J.T, Garba A, Halleux C, Keiser J, King C.H, Mutapi F, N'Goran E.K, Raso G, Scherrer A.U, Sousa-Figueiredo J.C, Stete K, Utzinger J, Vaillant M.T. Efficacy and safety of single 40 mg/kg oral praziquantel in the treatment of schistosomiasis in preschool-age versus school-age children: an individual participant data meta-analysis. PLoS Negl Trop Dis. 2020;14(6):e0008277. DOI: 10.1371/journal.pntd.0008277

Palmeirim M.S, Bosch F, Ame S.M, Ali S.M, Hattendorf J, Keiser J. Efficacy, safety and acceptability of a new chewable formulationversusthe solid tablet of mebendazole against hookworm infections in children: an open-label, randomized controlled trial. EClinicalMedicine. 2020;27:100556. DOI: 10.1016/j.eclinm.2020.100556

Palmeirim M.S, Ross A, Obrist B, Mohammed U.A, Ame S.M, Ali S.M, Keiser J. Informed consent procedure in a double blind randomized anthelminthic trial on Pemba Island, Tanzania: do pamphlet and information session increase caregivers knowledge?. BMC Med Ethics. 2020;21:1. DOI: 10.1186/s12910-019-0441-3

Patel C, Coulibaly J.T, Schulz J.D, N'Gbesso Y, Hattendorf J, Keiser J. Efficacy and safety of ascending dosages of albendazole against Trichuris trichiura in preschool-aged children, school-aged children and adults: a multi-cohort randomized controlled trial. EClinicalMedicine. 2020;22:100335. DOI: 10.1016/j.eclinm.2020.100335

Probst A, Häberli C, Siegel D, Huang J, Vigneron S, Ta A.P, Skinner D.E, El-Sakkary N, Momper J.D, Gangoiti J, Dong Y, Vennerstrom J.L, Charman S.A, Caffrey C.R, Keiser J. Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone. J Antimicrob Chemother. 2020:dkaa247. DOI: 10.1093/jac/dkaa247

Ravaynia P.S, Lombardo F.C, Biendl S, Dupuch M.A, Keiser J, Hierlemann A, Modena M.M. Parallelized impedance-based platform for continuous dose-response characterization of antischistosomal drugs. Adv Biosyst. 2020;4(7):e1900304. DOI: 10.1002/adbi.201900304

Twumasi E.B, Akazue P.I, Kyeremeh K, Gwira T.M, Keiser J, Cho-Ngwa F, Flint A, Anibea B, Bonsu E.Y, Amewu R.K, Amoah L.E, Appiah-Opong R, Osei-Safo D. Antischistosomal, antionchocercal and antitrypanosomal potentials of some Ghanaian traditional medicines and their constituents. PLoS Negl Trop Dis. 2020;14(12):e0008919. DOI: 10.1371/journal.pntd.0008919

Vlaminck J, Cools P, Albonico M, Ame S, Ayana M, Dana D, Keiser J, Matoso L.F, Montresor A, Mekonnen Z, Correa-Oliveira R, Pinto S.A, Sayasone S, Vercruysse J, Levecke B. An in-depth report of quality control on Kato-Katz and data entry in four clinical trials evaluating the efficacy of albendazole against soil-transmitted helminth infections. PLoS Negl Trop Dis. 2020;14(9):e0008625. DOI: 10.1371/journal.pntd.0008625

Vlaminck J, Cools P, Albonico M, Ame S, Chanthapaseuth T, Viengxay V, Do Trung D, Osei-Atweneboana M.Y, Asuming-Brempong E, Jahirul Karim M, Al Kawsar A, Keiser J, Khieu V, Faye B, Turate I, Mbonigaba J.B, Ruijeni N, Shema E, Lucianez A, Santiago Nicholls R, Jamsheed M, Mikhailova A, Montresor A, Mupfasoni D, Yajima A, Ngina Mwinzi P, Gilleard J, Prichard R.K, Verweij J.J, Vercruysse J, Levecke B. Piloting a surveillance system to monitor the global patterns of drug efficacy and the emergence of anthelmintic resistance in soil-transmitted helminth control programs: a Starworms study protocol. Gates Open Res. 2020;4:28. DOI: 10.12688/gatesopenres.13115.1

Wagner-Hattler L, Quebatte G, Keiser J, Schoelkopf J, Schleputz C.M, Huwyler J, Puchkov M. Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering. Int J Pharm. 2020;573:118827. DOI: 10.1016/j.ijpharm.2019.118827

Wu J, Wang X, Chiu F.C.K, Häberli C, Shackleford D.M, Ryan E, Kamaraj S, Bulbule V.J, Wallick A.I, Dong Y, White K.L, Davis P.H, Charman S.A, Keiser J, Vennerstrom J.L. Structure-activity relationship of antischistosomal ozonide carboxylic acids. J Med Chem. 2020;63(7):3723-3736. DOI: 10.1021/acs.jmedchem.0c00069

Zanolla D, Hasa D, Arhangelskis M, Schneider-Rauber G, Chierotti M.R, Keiser J, Voinovich D, Jones W, Perissutti B. Mechanochemical formation of racemic praziquantel hemihydrate with improved biopharmaceutical properties. Pharmaceutics. 2020;12(3):289. DOI: 10.3390/pharmaceutics12030289

Albertini B, Perissutti B, Bertoni S, Zanolla D, Franceschinis E, Voinovich D, Lombardo F, Keiser J, Passerini N. Combining mechanochemistry and spray congealing for new praziquantel pediatric formulations in schistosomiasis treatment. Int J Mol Sci. 2019;20(5):1233. DOI: 10.3390/ijms20051233

Bogoch I.I, Speich B, Lo N.C, Moser W, Croll D, Ali S.M, Ame S.M, Utzinger J, Andrews J.R, Keiser J. Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania. PLoS Negl Trop Dis. 2019;13(7):e0007581. DOI: 10.1371/journal.pntd.0007581

Brecht K, Kirchhofer C, Bouitbir J, Trapani F, Keiser J, Krähenbühl S. Exogenous iron increases fasciocidal activity and hepatocellular toxicity of the synthetic endoperoxides OZ78 and MT04. Int J Mol Sci. 2019;20(19):E4880. DOI: 10.3390/ijms20194880

Brussee J.M, Schulz J.D, Coulibaly J.T, Keiser J, Pfister M. Ivermectin dosing strategy to achieve equivalent exposure coverage in children and adults. Clin Pharmacol Ther. 2019;106(3):661-667. DOI: 10.1002/cpt.1456

Cools P, Vlaminck J, Albonico M, Ame S, Ayana M, Jose Antonio B.P, Cringoli G, Dana D, Keiser J, Maurelli M.P, Maya C, Matoso L.F, Montresor A, Mekonnen Z, Mirams G, Correa-Oliveira R, Pinto S.A, Rinaldi L, Sayasone S, Thomas E, Verweij J.J, Vercruysse J, Levecke B. Diagnostic performance of a single and duplicate Kato-Katz, Mini-FLOTAC, FECPAKG2 and qPCR for the detection and quantification of soil-transmitted helminths in three endemic countries. PLoS Negl Trop Dis. 2019;13(8):e0007446. DOI: 10.1371/journal.pntd.0007446

Coulibaly J.T, Hiroshige N, N'Gbesso Y.K, Hattendorf J, Keiser J. Efficacy and safety of ascending dosages of tribendimidine against hookworm infections in children: a randomized controlled trial. Clin Infect Dis. 2019;69(5):845-852. DOI: 10.1093/cid/ciy999

Hürlimann E, Keiser J. A single dose of ivermectin is sufficient for strongyloidiasis. Lancet Infect Dis. 2019;19(11):1150-1151. DOI: 10.1016/S1473-3099(19)30519-5

Karpstein T, Pasche V, Häberli C, Scandale I, Neodo A, Keiser J. Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections. Parasit Vectors. 2019;12:226. DOI: 10.1186/s13071-019-3476-x

Keiser J, Utzinger J. Community-wide soil-transmitted helminth treatment is equity-effective. Lancet. 2019;393(10185):2011-2012. DOI: 10.1016/S0140-6736(18)32981-7

Kyne G.M, Curtis M.P, Keiser J, Woods D.J. Soil-transmitted helminthiasis - challenges with discovery of novel anthelmintics. In: Swinney D.C,Pollastri M.P, eds. Neglected tropical diseases: drug discovery and development. 77, 227-251. Weinheim: Wiley, 2019. DOI: 10.1002/9783527808656.ch9

Le T.G, Kundu A, Ghoshal A, Nguyen N.H, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang B.C.H, Garcia-Bustos J, Wells T.N.C, Palmer M.J, Jabbar A, Gasser R.B, Baell J.B. Novel 1-methyl-1 H-pyrazole-5-carboxamide derivatives with potent anthelmintic activity. J Med Chem. 2019;62(7):3367-3380. DOI: 10.1021/acs.jmedchem.8b01790

Le T.G, Kundu A, Ghoshal A, Nguyen N.H, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang B.C.H, Garcia-Bustos J, Wells T.N.C, Palmer M.J, Jabbar A, Gasser R.B, Baell J.B. Structure–activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of Haemonchus contortus development. J Med Chem. 2019;62(2):1036-1053. DOI: 10.1021/acs.jmedchem.8b01789

Lombardo F.C, Pasche V, Panic G, Endriss Y, Keiser J. Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni. Nat Protoc. 2019;14(2):461-481. DOI: 10.1038/s41596-018-0101-y

Lombardo F.C, Perissutti B, Keiser J. Activity and pharmacokinetics of a praziquantel crystalline polymorph in the Schistosoma mansoni mouse model. Eur J Pharm Biopharm. 2019;142:240-246. DOI: 10.1016/j.ejpb.2019.06.029

Maccesi M, Aguiar P.H.N, Pasche V, Padilla M, Suzuki B.M, Montefusco S, Abagyan R, Keiser J, Mourao M.M, Caffrey C.R. Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery. Parasit Vectors. 2019;12:493. DOI: 10.1186/s13071-019-3747-6

Mayoka G, Keiser J, Häberli C, Chibale K. Structure–activity relationship and in vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies of N-aryl 3-trifluoromethyl pyrido[1,2-a]benzimidazoles that are efficacious in a mouse model of schistos. ACS Infect Dis. 2019;5(3):418-429. DOI: 10.1021/acsinfecdis.8b00313

Meister I, Assawasuwannakit P, Vanobberghen F, Penny M, Odermatt P, Sayasone S, Huwyler J, Tarning J, Keiser J. Pooled population pharmacokinetic analysis of tribendimidine for the treatment of Opisthorchis viverrini infections. Antimicrob Agents Chemother. 2019;63(4):e01391-18. DOI: 10.1128/AAC.01391-18

Moser W, Schindler C, Keiser J. Drug combinations against soil-transmitted helminth infections. Adv Parasitol. 2019;103:91-115. DOI: 10.1016/bs.apar.2018.08.002

Neodo A, Schulz J.D, Huwyler J, Keiser J. In vitro and in vivo drug-drug interaction study of the effects of ivermectin and oxantel pamoate on tribendimidine. Antimicrob Agents Chemother. 2019;63(1):e00762-18. DOI: 10.1128/AAC.00762-18

Panic G, Barda B, Kovac J, Coulibaly J.T, Keiser J. Evaluation of the Clinitek®, a point-of-care urinalysis system for the measurement of clinically significant urinary metabolites and detection of haematuria in Schistosoma haematobium infected children in southern Côte d'Ivoire. Parasit Vectors. 2019;12:298. DOI: 10.1186/s13071-019-3555-z

Pasche V, Laleu B, Keiser J. Early antischistosomal leads identified from in vitro and in vivo screening of the Medicines for Malaria Venture pathogen box. ACS Infect Dis. 2019;5(1):102-110. DOI: 10.1021/acsinfecdis.8b00220

Patel C, Hürlimann E, Keller L, Hattendorf J, Sayasone S, Ali S.M, Ame S.M, Coulibaly J.T, Keiser J. Efficacy and safety of ivermectin and albendazole co-administration in school-aged children and adults infected with Trichuris trichiura: study protocol for a multi-country randomized controlled double-blind trial. BMC Infect Dis. 2019;19:262. DOI: 10.1186/s12879-019-3882-x

Schulz J.D, Coulibaly J.T, Schindler C, Wimmersberger D, Keiser J. Pharmacokinetics of ascending doses of ivermectin in Trichuris trichiura-infected children aged 2-12 years. J Antimicrob Chemother. 2019;74(6):1642-1647. DOI: 10.1093/jac/dkz083

Schulz J.D, Neodo A, Coulibaly J.T, Keiser J. Pharmacokinetics of albendazole, albendazole sulfoxide and albendazole sulfone determined from plasma, blood, dried blood spots and Mitra® samples of hookworm-infected adolescents. Antimicrob Agents Chemother. 2019;63(4):e02489-18. DOI: 10.1128/AAC.02489-18

Vlaminck J, Cools P, Albonico M, Ame S, Ayana M, Cringoli G, Dana D, Keiser J, Maurelli M.P, Matoso L.F, Montresor A, Mekonnen Z, Mirams G, Correa-Oliveira R, Pinto S.A, Rinaldi L, Sayasone S, Thomas E, Vercruysse J, Verweij J.J, Levecke B. Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods. PLoS Negl Trop Dis. 2019;13(8):e0007471. DOI: 10.1371/journal.pntd.0007471

Wimmersberger D, Schulz J.D, Keiser J. Antihelminthic efficacy against trichuriasis: Reply to Nalin. Clin Infect Dis. 2019;69(2):376-377. DOI: 10.1093/cid/ciy1015

Zanolla D, Perissutti B, Vioglio P.C, Chierotti M.R, Gigli L, Demitri N, Passerini N, Albertini B, Franceschinis E, Keiser J, Voinovich D. Exploring mechanochemical parameters using a DoE approach: crystal structure solution from Synchrotron XRPD and characterization of a new praziquantel polymorph. Eur J Pharm Sci. 2019;140:1005084. DOI: 10.1016/j.ejps.2019.105084

Ayana M, Vlaminck J, Cools P, Ame S, Albonico M, Dana D, Keiser J, Manly H, Matoso L.F, Mekonnen Z, Montresor A, Correa-Oliveira R, Rinaldi L, Sayasone S, Tesfaye L, Vercruysse J, Mirams G, Levecke B. Modification and optimization of the FECPAKG2 protocol for the detection and quantification of soil-transmitted helminth eggs in human stool. PLoS Negl Trop Dis. 2018;12(10):e0006655. DOI: 10.1371/journal.pntd.0006655

Barda B, Ame M.S, Ali M.S, Albonico M, Puchkov M, Huwyler J, Hattendorf J, Keiser J. Efficacy and tolerability of moxidectin alone and in co-administration with albendazole plus oxantel pamoate against Trichuris trichiura infections: a randomised, non inferority, single-blind trial. Lancet Infect Dis. 2018;18(8):864-873. DOI: 10.1016/S1473-3099(18)30233-0

Barda B, Wampfler R, Sayasone S, Phongluxa K, Xayavong S, Keoduangsy K, Schindler C, Keiser J. Evaluation of two DNA extraction methods on the detection of Strongyloides stercoralis infection. J Clin Microbiol. 2018;56(4):e01941-17. DOI: 10.1128/JCM.01941-17

Becker S.L, Liwanag H.J, Snyder J.S, Akogun O, Belizario V. Jr, Freeman M.C, Gyorkos T.W, Imtiaz R, Keiser J, Krolewiecki A, Levecke B, Mwandawiro C, Pullan R.L, Addiss D.G, Utzinger J. Toward the 2020 goal of soil-transmitted helminthiasis control and elimination. PLoS Negl Trop Dis. 2018;12(8):e0006606. DOI: 10.1371/journal.pntd.0006606

Bonate P.L, Wang T, Passier P, Bagchus W, Burt H, Lupfert C, Abla N, Kovac J, Keiser J. Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale. J Pharmacokinet Pharmacodyn. 2018;45(5):747-762. DOI: 10.1007/s10928-018-9601-1

Buchter V, Hess J, Gasser G, Keiser J. Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy. Parasit Vectors. 2018;11(1):580. DOI: 10.1186/s13071-018-3132-x

Chawla K, Modena M.M, Ravaynia P.S, Lombardo F.C, Leonhardt M, Panic G, Burgel S.C, Keiser J, Hierlemann A. Impedance-based microfluidic assay for automated antischistosomal drug screening. ACS Sens. 2018;3(12):2613-2620. DOI: 10.1021/acssensors.8b01027

Coulibaly J.T, Andrews J.R, Lo N.C, N'Goran E.K, Utzinger J, Keiser J, Bogoch II. Schistosoma haematobium egg excretion does not increase after exercise: implications for diagnostic testing. Am J Trop Med Hyg. 2018;98(3):772-775. DOI: 10.4269/ajtmh.17-0728

Coulibaly J.T, Ouattara M, Barda B, Utzinger J, N'Goran E.K, Keiser J. A rapid appraisal of factors influencing praziquantel treatment compliance in two communities endemic for schistosomiasis in Côte d'Ivoire. Trop Med Infect Dis. 2018;3(2):E69. DOI: 10.3390/tropicalmed3020069

Coulibaly J.T, Panic G, Yapi R.B, Kovac J, Barda B, N'Gbesso Y.K, Hattendorf J, Keiser J. Efficacy and safety of ascending doses of praziquantel against Schistosoma haematobium infection in preschool-aged and school-aged children: a single-blind randomised controlled trial. BMC Med. 2018;16:81. DOI: 10.1186/s12916-018-1066-y

D'Orchymont F, Hess J, Panic G, Jakubaszek M, Gemperle L, Keiser J, Gasser G. Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates. MedChemComm. 2018;9(11):1905-1909. DOI: 10.1039/C8MD00396C

Hiroshige N, Coulibaly J, Huwyler J, Bonate P.L, Keiser J. Pharmacokinetics of a pediatric tribendimidine dose-finding study to treat hookworm infection in African children. Antimicrob Agents Chemother. 2018;62(9):e00959-18. DOI: 10.1128/AAC.00959-18

Kovac J, Meister I, Neodo A, Panic G, Coulibaly J.T, Falcoz C, Keiser J. Pharmacokinetics of praziquantel in Schistosoma mansoni and Schistosoma haematobium infected school- and preschool- aged children. Antimicrob Agents Chemother. 2018;62(8):e02253-17. DOI: 10.1128/AAC.02253-17

Kovac J, Panic G, Neodo A, Meister I, Coulibaly J.T, Schulz J.D, Keiser J. Evaluation of a novel micro-sampling device, MitaTM, in comparison to dried blood spots, for analysis of praziquantel in Schistosoma haematobium -infected children in rural Côte d'lvoire. J Pharm Biomed Anal. 2018;151:339-346. DOI: 10.1016/j.jpba.2018.01.030

Le T.G, Kundu A, Ghoshal A, Nguyen N.H, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang B.C.H, Garcia-Bustos J, Jabbar A, Wells T.N.C, Palmer M.J, Gasser R.B, Baell J.B. Optimization of novel 1-methyl-1 h-pyrazole-5-carboxamides leads to high potency larval development inhibitors of the barber's pole worm. J Med Chem. 2018;61(23):10875–10894. DOI: 10.1021/acs.jmedchem.8b01544

Levecke B, Easton A.V, Cools P, Albonico M, Ame S, Gilleard J, Keiser J, Montresor A, Prichard R.K, Vlaminck J, Vercruysse J. The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans. Int J Parasitol Drugs Drug Resist. 2018;8(1):67-69. DOI: 10.1016/j.ijpddr.2017.12.004

Liu Z, Xia B, Saric J, Utzinger J, Holmes E, Keiser J, Li J.V. Effects of vancomycin and ciprofloxacin on the NMRI mouse metabolism. J Proteome Res. 2018;17(10):3565-3573. DOI: 10.1021/acs.jproteome.8b00583

Moser W, Bärenbold O, Mirams G.J, Cools P, Vlaminck J, Ali S.M, Ame S.M, Hattendorf J, Vounatsou P, Levecke B, Keiser J. Diagnostic comparison between FECPAKG2 and the Kato-Katz method for analyzing soil-transmitted helminth eggs in stool. PLoS Negl Trop Dis. 2018;12(6):e0006562. DOI: 10.1371/journal.pntd.0006562

Moser W, Sayasone S, Xayavong S, Bounheuang B, Puchkov M, Huwyler J, Hattendorf J, Keiser J. Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate again. Lancet Infect Dis. 2018;18(7):729-737. DOI: 10.1016/S1473-3099(18)30220-2

Palmeirim M.S, Ame S.M, Ali S.M, Hattendorf J, Keiser J. Efficacy and safety of a single dose versus a multiple dose regimen of mebendazole against hookworm infections in children: a randomised, double-blind trial. EClinicalMedicine. 2018;1:7-13. DOI: 10.1016/j.eclinm.2018.06.004

Palmeirim M.S, Hürlimann E, Knopp S, Speich B, Belizario V.Jr, Joseph S.A, Vaillant M, Olliaro P, Keiser J. Efficacy and safety of co-administered ivermectin plus albendazole for treating soil-transmitted helminths: a systematic review meta-analysis and individual patient data analysis. PLoS Negl Trop Dis. 2018;12(4):e0006458. DOI: 10.1371/journal.pntd.0006458

Panic G, Coulibaly J.T, Harvey N, Keiser J, Swann J. Characterizing the biochemical response to Schistosoma mansoni infection and treatment with praziquantel in preschool and school aged children. J Proteome Res. 2018;17(6):2028-2033. DOI: 10.1021/acs.jproteome.7b00910

Panic G, Keiser J. Acting beyond 2020: better characterization of praziquantel and promising antischistosomal leads. Curr Opin Pharmacol. 2018;42:27-33. DOI: 10.1016/j.coph.2018.06.004

Pasche V, Laleu B, Keiser J. Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni. Parasit Vectors. 2018;11:298. DOI: 10.1186/s13071-018-2855-z

Sayasone S, Keiser J, Meister I, Vonghachack Y, Xayavong S, Senggnam K, Phongluxa K, Hattendorf J, Odermatt P. Efficacy and safety of tribendimidine versus praziquantel against Opisthorchis viverrini in Laos: an open-label, randomised, non-inferiority, phase 2 trial. Lancet Infect Dis. 2018;18(2):155-161. DOI: 10.1016/S1473-3099(17)30624-2

Schneeberger P.H.H, Coulibaly J.T, Gueuning M, Moser W, Coburn B, Frey J.E, Keiser J. Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota. Int J Parasitol Drugs Drug Resist. 2018;8(3):372-378. DOI: 10.1016/j.ijpddr.2018.07.001

Schneeberger P.H.H, Coulibaly J.T, Panic G, Daubenberger C, Gueuning M, Frey J.E, Keiser J. Investigations on the interplays between Schistosoma mansoni, praziquantel and the gut microbiome. Parasit Vectors. 2018;11:168. DOI: 10.1186/s13071-018-2739-2

Schulz J.D, Moser W, Hürlimann E, Keiser J. Preventive chemotherapy in the fight against soil-transmitted helminthiasis: achievements and limitations. Trends Parasitol. 2018;34(7):590-602. DOI: 10.1016/j.pt.2018.04.008

Schulz J.D, Neodo A, Coulibaly J.T, Keiser J. Development and validation of a LC-MS/MS method for ivermectin quantification in dried blood spots: application to a pharmacokinetic study in Trichuris trichiura-infected adults. Analytical Methods. 2018;10(24):2901-2909. DOI: 10.1039/c8ay00828k

Speich B, Von Niederhäusern B, Blum C.A, Keiser J, Schur N, Fürst T, Kasenda B, Christ-Crain M, Hemkens L.G. Retrospective assessment of resource use and costs in two investigator-initiated randomised trials exemplified a comprehensive cost item list. J Clin Epidemiol. 2018;96:73-83. DOI: 10.1016/j.jclinepi.2017.12.022

Vlaminck J, Cools P, Albonico M, Ame S, Ayana M, Bethony J, Cringoli G, Dana D, Keiser J, Maurelli M.P, Montresor A, Mekonnen Z, Mirams G, Correa-Oliveira R, Prichard R, Rashwan N, Rinaldi L, Sayasone S, Thomas E, Verweij J.J, Vercruysse J, Levecke B. Comprehensive evaluation of stool-based diagnostic methods and benzimidazole resistance markers to assess drug efficacy and detect the emergence of anthelmintic resistance: a starworms study protocol. PLoS Negl Trop Dis. 2018;12(11):e0006912. DOI: 10.1371/journal.pntd.0006912

Wimmersberger D, Coulibaly J.T, Schulz J, Puchkow M, Huwyler J, N'Gbesso Y, Hattendorf J, Keiser J. Efficacy and safety of ivermectin against Trichuris trichiura in preschool- and school-aged children: a randomized controlled dose-finding trial. Clin Infect Dis. 2018;67(8):1247-1255. DOI: 10.1093/cid/ciy246

Wu J, Wang C, Häberli C, White K.L, Shackleford D.M, Chen G, Dong Y, Charman S.A, Keiser J, Vennerstrom J.L. SAR of a new antischistosomal urea carboxylic acid. Bioorg Med Chem Lett. 2018;28(23-24):3648-3651. DOI: 10.1016/j.bmcl.2018.10.039

Wu J, Wang C, Leas D, Vargas M, White K.L, Shackleford D.M, Chen G, Sanford A.G, Hemsley R.M, Dong Y, Charman S.A, Keiser J, Vennerstrom J.L. Progress in antischistosomal N,N'-diaryl urea SAR. Bioorg Med Chem Lett. 2018;28(3):244-248. DOI: 10.1016/j.bmcl.2017.12.064

Zanolla D, Perissutti B, Passerini N, Chierotti M.R, Hasa D, Voinovich D.Gigli L, Demitri N, Geremia S, Keiser J, Vioglio P.C. A new soluble and bioactive polymorph of praziquantel. Eur J Pharm Biopharm. 2018;127:19-28. DOI: 10.1016/j.ejpb.2018.01.018

Abla N, Keiser J, Vargas M, Reimers N, Haas H, Spangenberg T. Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model. PLoS Negl Trop Dis. 2017;11(9):e0005942. DOI: 10.1371/journal.pntd.0005942

Barda B, Albonico M, Buonfrate D, Ame S.M, Ali S, Speich B, Keiser J. Side benefits of mass drug administration for lymphatic filariasis on Strongyloides stercoralis prevalence on Pemba Island, Tanzania. Am J Trop Med Hyg. 2017;97(3):681-683. DOI: 10.4269/ajtmh.17-0050

Barda B, Coulibaly J.T, Hatz C, Keiser J. Ultrasonographic evaluation of urinary tract morbidity in school-aged and preschool-aged children infected with Schistosoma haematobium and its evolution after praziquantel treatment: a randomized controlled trial. PLoS Negl Trop Dis. 2017;11(2):e0005400. DOI: 10.1371/journal.pntd.0005400

Barda B, Sayasone S, Phongluxa K, Xayavong S, Keoduangsy K, Odermatt P, Puchkov M, Huwyler J, Hattendorf J, Keiser J. Efficacy of moxidectin versus ivermectin against Strongyloides stercoralis infections: a randomized controlled non-inferiority trial. Clin Infect Dis. 2017;65(2):276-281. DOI: 10.1093/cid/cix278

Bergquist R, Utzinger J, Keiser J. Controlling schistosomiasis with praziquantel: how much longer without a viable alternative?. Infect Dis Poverty. 2017;6(1):74. DOI: 10.1186/s40249-017-0286-2

Bogoch I.I, Coulibaly J.T, Rajchgot J, Andrews J.R, Kovac J, Utzinger J, Panic G, Keiser J. Poor validity of noninvasive hemoglobin measurements by pulse oximetry compared with conventional absorptiometry in children in Côte d'Ivoire. Am J Trop Med Hyg. 2017;96(1):217-220. DOI: 10.4269/ajtmh.16-0505

Coulibaly J.T, Panic G, Silué K.D, Kovac J, Hattendorf J, Keiser J. Efficacy and safety of praziquantel in preschool-aged and school-aged children infected with Schistosoma mansoni: a randomised controlled, parallel-group, dose-ranging, phase 2 trial. Lancet Glob Health. 2017;5(7):e688-e698. DOI: 10.1016/S2214-109X(17)30187-0

Cowan N, Meier C, Neodo A, Keiser J. Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in vitro and in vivo to elucidate the pathway of drug entry into these gastrointestinal ne. Int J Parasitol Drugs Drug Resist. 2017;7(2):159-173. DOI: 10.1016/j.ijpddr.2017.03.005

Greter H, Cowan N, Ngandolo B.N, Kessely H, Alfaroukh I.O, Utzinger J, Keiser J, Zinsstag J. Treatment of human and livestock helminth infections in a mobile pastoralist setting at Lake Chad: attitudes to health and analysis of active pharmaceutical ingredients of locally available anthelminthic drugs. Acta Trop. 2017;175:91-99. DOI: 10.1016/j.actatropica.2016.05.012

Hess J, Panic G, Patra M, Mastrobuoni L, Spingler B, Roy S, Keiser J, Gasser G. Ferrocenyl, ruthenocenyl, and benzyl oxamniquine derivatives with cross-species activity against Schistosoma mansoni and Schistosoma haematobium. ACS Infect Dis. 2017;3(9):645-652. DOI: 10.1021/acsinfecdis.7b00054

Keiser J. Jennifer Keiser - tackling drug resistance before it arises. Trends Parasitol. 2017;33(3):153-154. DOI: 10.1016/j.pt.2016.11.010

Kovac J, Vargas M, Keiser J. In vitro and in vivo activity of R- and S-praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium. Parasit Vectors. 2017;10:365. DOI: 10.1186/s13071-017-2293-3

Modena M.M, Chawla K, Lombardo F, Bürgel S.C, Panic G, Keiser J, Hierlemann A. Impedance-based detection of Schistosoma mansoni larvae viability for drug screening. IEEE Biomedical Circuits and Systems Conference (BioCAS). Turin: IEEE, 2017:1-4. DOI: 10.1109/BIOCAS.2017.8325227

Moser W, Coulibaly J.T, Ali S.M, Ame S.M, Amour A.K, Yapi R.B, Albonico M, Puchkov M, Huwyler J, Hattendorf J, Keiser J. Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomi. Lancet Infect Dis. 2017;17(11):1162-1171. DOI: 10.1016/S1473-3099(17)30487-5

Moser W, Labhardt N.D, Cheleboi M, Muhairwe J, Keiser J. Unexpected low soil-transmitted helminth prevalence in the Butha-Buthe district in Lesotho, results from a cross-sectional survey. Parasit Vectors. 2017;10(1):72. DOI: 10.1186/s13071-017-1995-x

Moser W, Schindler C, Keiser J. Efficacy of recommended drugs against soil transmitted helminths: systematic review and netword meta-analysis. BMJ. 2017;385:j4307. DOI: 10.1136/bmj.j4307

Okombo J, Singh K, Mayoka G, Ndubi F, Barnard L, Njogu P.M, Njoroge M, Gibhard L, Brunschwig C, Vargas M, Keiser J, Egan T.J, Chibale K. Antischistosomal activity of pyrido[1,2-a]benzimidazole derivatives and correlation with inhibition of beta-hematin formation. ACS Infect Dis. 2017;3(6):411-420. DOI: 10.1021/acsinfecdis.6b00205

Panic G, Ruf M.T, Keiser J. Immunohistochemical investigations of treatment with Ro 13-3978, praziquantel, oxamniquine and mefloquine in Schistosoma mansoni-infected mice. Antimicrob Agents Chemother. 2017;61(12):e01142-17. DOI: 10.1128/AAC.01142-17

Perissutti B, Passerini N, Trastullo R, Keiser J, Zanolla D, Zingone G, Voinovich D, Albertini B. An explorative analysis of process and formulation variables affecting comilling in a vibrational mill: the case of praziquantel. Int J Pharm. 2017;533(2):402-412. DOI: 10.1016/j.ijpharm.2017.05.053

Preston S, Jiao Y, Baell J.B, Keiser J, Crawford S, Koehler A.V, Wang T, Simpson M.M, Kaplan R.M, Cowley K.J, Simpson K.J, Hofmann A, Jabbar A, Gasser R.B. Screening of the 'Open Scaffolds' collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes. Int J Parasitol Drugs Drug Resist. 2017;7(3):286-294. DOI: 10.1016/j.ijpddr.2017.05.004

Rajchgot J, Coulibaly J.T, Keiser J, Utzinger J, Lo N.C, Mondry M.K, Andrews J.R, Bogoch II. Mobile-phone and handheld microscopy for neglected tropical diseases. PLoS Negl Trop Dis. 2017;11(7):e0005550. DOI: 10.1371/journal.pntd.0005550

Sayasone S, Meister I, Andrews J.R, Odermatt P, Vonghachack Y, Xayavong S, Senggnam K, Phongluxa K, Hattendorf J, Bogoch II, Keiser J. Efficacy and safety of praziquantel against light infections of Opisthorchis viverrini: a randomised parallel single blind dose-ranging trial. Clin Infect Dis. 2017;64(4):451-458. DOI: 10.1093/cid/ciw785

Tritten L, Tam M, Vargas M, Jardim A, Stevenson M.M, Keiser J, Geary T.G. Excretory/secretory products from the gastrointestinal nematode Trichuris muris. Exp Parasitol. 2017;178:30-36. DOI: 10.1016/j.exppara.2017.05.003

Albonico M, Becker S.L, Odermatt P, Angheben A, Anselmi M, Amor A, Barda B, Buonfrate D, Cooper P, Gétaz L, Keiser J, Khieu V, Montresor A, Muñoz J, Requena-Méndez A, Savioli L, Speare R, Steinmann P, van Lieshout L, Utzinger J, Bisoffi Z, StrongNet Working Group. StrongNet: an international network to improve diagnostics and access to treatment for strongyloidiasis control. PLoS Negl Trop Dis. 2016;10(9):e0004898. DOI: 10.1371/journal.pntd.0004898

Barda B, Coulibaly J.T, Puchkov M, Huwyler J, Hattendorf J, Keiser J. Efficacy and safety of moxidectin, synriam, synriam-praziquantel versus praziquantel against Schistosoma haematobium and S. mansoni infections: a randomized, exploratory phase 2 trial. PLoS Negl Trop Dis. 2016;10(9):e0005008. DOI: 10.1371/journal.pntd.0005008

Bogoch I.I, Sayasone S, Vonghachack Y, Meister I, Utzinger J, Odermatt P, Andrews J.R, Keiser J. Diagnosis of Opisthorchis viverrini infection with handheld light microscopy in Lao People's Democratic Republic. Am J Trop Med Hyg. 2016;94(1):158-160. DOI: 10.4269/ajtmh.15-0525

Clède S, Cowan N, Lambert F, Bertrand H.C, Rubbiani R, Patra M, Hess J, Sandt C, Trcera N, Gasser G, Keiser J, Policar C. Bimodal X-ray and infrared imaging of an organometallic derivative of praziquantel in Schistosoma mansoni. Chembiochem. 2016;17(11):1004-1007. DOI: 10.1002/cbic.201500688

Coulibaly J.T, Ouattara M, Becker S.L, Lo N.C, Keiser J, N'Goran E.K, Ianniello D, Rinaldi L, Cringoli G, Utzinger J. Comparison of sensitivity and faecal egg counts of mini-FLOTAC using fixed stool samples and Kato-Katz technique for the diagnosis of Schistosoma mansoni and soil-transmitted helminths. Acta Trop. 2016;164:107-116. DOI: 10.1016/j.actatropica.2016.08.024

Coulibaly J.T, Ouattara M, D'Ambrosio M.V, Fletcher D.A, Keiser J, Utzinger J, N'Goran E.K, Andrews J.R, Bogoch I.I. Accuracy of mobile phone and handheld light microscopy for the diagnosis of schistosomiasis and intestinal protozoa infections in Côte d'Ivoire. PLoS Negl Trop Dis. 2016;10(6):e0004768. DOI: 10.1371/journal.pntd.0004768

Coulibaly J.T, Ouattara M, Keiser J, Bonfoh B, N'Goran E.K, Andrews J.R, Bogoch II. Evaluation of malaria diagnoses using a handheld light microscope in a community-based setting in rural Côte d'Ivoire. Am J Trop Med Hyg. 2016;95(4):831-834. DOI: 10.4269/ajtmh.16-0328

Cowan N, Raimondo A, Keiser J. Approved oncology drugs lack in vivo activity against Trichuris muris despite in vitro activity. Parasitol Res. 2016;115(11):4443-4446. DOI: 10.1007/s00436-016-5225-9

Cowan N, Vargas M, Keiser J. In vitro and in vivo drug interaction study of two lead combinations, oxantel pamoate plus albendazole and albendazole plus mebendazole, for the treatment of soil-transmitted helminthiasis. Antimicrob Agents Chemother. 2016;60(10):6127-6133. DOI: 10.1128/AAC.01217-16

Duthaler U, Sayasone S, Vanobbergen F, Penny M, Odermatt P, Huwyler J, Keiser J. Single ascending dose pharmacokinetic study of tribendimidine in Opisthorchis viverrini-infected patients. Antimicrob Agents Chemother. 2016;60(10):5705-5715. DOI: 10.1128/AAC.00992-16

Flores D, Panic G, Braissant O, Keiser J. A novel isothermal microcalorimetry tool to assess drug effects on Ancylostoma ceylanicum and Necator americanus. Appl Microbiol Biotechnol. 2016;100(2):837-846. DOI: 10.1007/s00253-015-7081-4

Greter H, Batil A.A, Alfarouk I.O, Grimm F, Ngandolo B.N, Keiser J, Utzinger J, Zinsstag J, Hattendorf J. Re-infection with Fasciola gigantica 6-months post-treatment with triclabendazole in cattle from mobile pastoralist husbandry systems at Lake Chad. Vet Parasitol. 2016;230:43-48. DOI: 10.1016/j.vetpar.2016.10.019

Keiser J, Panic G, Adelfio R, Cowan N, Vargas M, Scandale I. Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections. Parasit Vectors. 2016;9:376. DOI: 10.1186/s13071-016-1616-0

Khan M.O, Keiser J, Amoyaw P.N, Hossain M.F, Vargas M, Le J.G, Simpson N.C, Roewe K.D, Freeman T.N, Hasley T.R, Maples R.D, Archibald S.J, Hubin T.J. Discovery of antischistosomal drug leads based on tetraazamacrocyclic derivatives and their metal complexes. Antimicrob Agents Chemother. 2016;60(9):5331-5336. DOI: 10.1128/AAC.00778-16

Leonidova A, Vargas M, Huwyler J, Keiser J. Pharmacokinetics of the antischistosomal lead ozonide OZ418 in uninfected mice determined by liquid chromatography-tandem mass spectrometry. Antimicrob Agents Chemother. 2016;60(12):7364-7371. DOI: 10.1128/AAC.02394-15

Lo N.C, Coulibaly J.T, Bendavid E, N'Goran E.K, Utzinger J, Keiser J, Bogoch II, Andrews J.R. Evaluation of a urine pooling strategy for the rapid and cost-efficient prevalence classification of schistosomiasis. PLoS Negl Trop Dis. 2016;10(8):e0004894. DOI: 10.1371/journal.pntd.0004894

Meister I, Kovac J, Duthaler U, Odermatt P, Huwyler J, Vanobberghen F, Sayasone S, Keiser J. Pharmacokinetic study of praziquantel enantiomers and its main metabolite R-trans-4-OH-PZQ in plasma, blood and dried blood spots in Opisthorchis viverrini-infected patients. PLoS Negl Trop Dis. 2016;10(5):e0004700. DOI: 10.1371/journal.pntd.0004700

Meister I, Leonidova A, Kovac J, Duthaler U, Keiser J, Hawyler J. Development and validation of an enantioselective LM-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots. J Pharm Biomed Anal. 2016;118:81-88. DOI: 10.1016/j.jpba.2015.10.011

Moser W, Ali S.M, Ame S.M, Speich B, Puchkov M, Huwyler J, Albonico M, Hattendorf J, Keiser J. Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba island, Tanzania: a parallel, randomised, controlled, dose-ranging study. Lancet Infect Dis. 2016;16(1):53-60. DOI: 10.1016/S1473-3099(15)00271-6

Qian M.-B, Utzinger J, Keiser J, Zhou X.-N. Clonorchiasis. Lancet. 2016;387(10020):800-810. DOI: 10.1016/S0140-6736(15)60313-0

Sayasone S, Odermatt P, Vonghachack Y, Xayavong S, Senggnam K, Duthaler U, Akkhavong K, Hattendorf J, Keiser J. Efficacy and safety of tribendimidine against Opisthorchis viverrini: two randomised, parallel-group, single-blind, dose-ranging, phase 2 trials. Lancet Infect Dis. 2016;16(10):1145-1153. DOI: 10.1016/s1473-3099(16)30198-0

Speich B, Croll D, Fürst T, Utzinger J, Keiser J. Effect of sanitation and water treatment on intestinal protozoa infection: a systematic review and meta-analysis. Lancet Infect Dis. 2016;16(1):87-99. DOI: 10.1016/S1473-3099(15)00349-7

Speich B, Moser W, Ali S.M, Ame S.M, Albonico M, Hattendorf J, Keiser J. Efficacy and reinfection with soil-transmitted helminths 18-weeks post-treatment with albendazole-ivermectin, albendazole-mebendazole, albendazole-oxantel pamoate and mebendazole. Parasit Vectors. 2016;9:123. DOI: 10.1186/s13071-016-1406-8

Van Voorhis W.C, Adams J.H, Adelfio R, Ahyong V, Akabas M.H, Alano P, Alday A, Aleman Resto Y, Alsibaee A, Alzualde A, Andrews K.T, Avery S.V, Avery V.M, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher L.E, Boyom F.F, Brea J, Brennan M, Burton A, Caffrey C.R, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon B.L, Colon-Lopez D.D, Corbett Y, Crowther G.J, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi J.L, Du A.Y, Duffy S, Abd El-Salam El-Sayed S, Ferdig M.T, Fernandez Robledo J.A, Fidock D.A, Florent I, Fokou P.V, Galstian A, Gamo F.J, Gokool S, Gold B, Golub T, Goldgof G.M, Guha R, Guiguemde W.A, Gural N, Guy R.K, Hansen M.A, Hanson K.K, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes T.B, Huston C, Igarashi I, Ingram-Sieber K, Itoe M.A, Jadhav A, Naranuntarat Jensen A, Jensen L.T, Jiang R.H, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar V.P, Kyle D.E, Lafuente M.J, Landfear S, Lee N, Lee S, Lehane A.M, Li F, Little D, Liu L, Llinas M, Loza M.I, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour N.R, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa A.N, Misra R.N, Moon S, Moore J.P, Morais Rodrigues da Costa F, Muller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo K.K, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe D.M, Poulsen S.A, Pradhan A, Quevedo C, Quinn R.J, Rice C.A, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett N.G, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith D.A, Soldati T, Spitzmuller A, Stamm S.M, Sullivan D.J, Sullivan W, Suresh S, Suzuki B.M, Suzuki Y, Swamidass S.J, Taramelli D, Tchokouaha L.R, Theron A, Thomas D, Tonissen K.F, Townson S, Tripathi A.K, Trofimov V, Udenze K.O, Ullah I, Vallieres C, Vigil E, Vinetz J.M, Voong Vinh P, Vu H, Watanabe N.A, Weatherby K, White P.M, Wilks A.F, Winzeler E.A, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo P.H, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis P.A. Open source drug discovery with the malaria box compound collection for neglected diseases and beyond. PLoS Pathog. 2016;12(7):e1005763. DOI: 10.1371/journal.ppat.1005763

Vanobberghen F, Penny M.A, Duthaler U, Odermatt P, Sayasone S, Keiser J, Tarning J. Population pharmacokinetic modeling of tribendimidine metabolites in Opisthorchis viverrini-infected adults. Antimicrob Agents Chemother. 2016;60(10):5695-5704. DOI: 10.1128/AAC.00655-16

Wang C, Zhao Q, Vergas M, Jones J.O, White K.L, Shackleford D.M, Chen G, Saunders J, Ng A.C.F, Chiu F.C.K, Dong Y, Charman S.A, Keiser J, Vennerstrom J.L. Revisiting the SAR of the antischistosomal aryl hydantoin (Ro 13-3978). J Med Chem. 2016;59:10705-10718. DOI: 10.1021/acs.jmedchem.6b01410

Barda B, Albonico M, Ianniello D, Ame S.M, Keiser J, Speich B, Rinaldi L, Cringoli G, Burioni R, Montresor A, Utzinger J. How long can stool samples be fixed for an accurate diagnosis of soil-transmitted helminth infection using mini-FLOTAC?. PLoS Negl Trop Dis. 2015;9(4):e0003698. DOI: 10.1371/journal.pntd.0003698

Barda B, Coulibaly J, Keiser J. Assessment of the safety and efficacy of oral Moxidectin, Synriam (R), Synriam (R) -praziquantel combination versus praziquantel in schoolchildren infected with Schistosoma haematobium and Schistosoma mansoni. Trop Med Int Health, 2015;20(Suppl. 1):53-54. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Barda B.D, Keiser J, Albonico M. Human trichuriasis: diagnostics update. Curr Trop Med Rep. 2015;2:201-208. DOI: 10.1007/s40475-015-0063-x

Braissant O, Keiser J, Meister I, Bachmann A, Wirz D, Gopfert B, Bonkat G, Wadso I. Isothermal microcalorimetry accurately detects bacteria, tumorous microtissues, and parasitic worms in a label-free well-plate assay. Biotechnol J. 2015;10(3):460-480. DOI: 10.1002/biot.201400494

Cowan N, Datwyler P, Ernst B, Wang C, Vennerstrom J.L, Spangenberg T, Keiser J. Activities of N,N' -diarylurea MMV665852 analogs against Schistosoma mansoni. Antimicrob Agents Chemother. 2015;59(4):1935-1941. DOI: 10.1128/AAC.04463-14

Cowan N, Keiser J. Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni. Parasit Vectors. 2015;8:417. DOI: 10.1186/s13071-015-1023-y

Cowan N, Yaremenko I.A, Krylov I, Terent'ev A.O, Keiser J. Elucidation of the in vitro and in vivo activities of bridged 1,2,4-trioxolanes, bridged 1,2,4,5-tetraoxanes, tricyclic monoperoxides, silyl peroxides, and hydroxylamine derivatives against Schistosoma mansoni.. Bioorg Med Chem. 2015;23(16):5175-5181. DOI: 10.1016/j.bmc.2015.02.010

Duthaler U, Keiser J, Huwyler J. LC-MS/MS method for the determinatin of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots. J Pharm Biomed Anal. 2015;105:163-173. DOI: 10.1016/j.jpba.2014.12.006

Ephraim R.K, Duah E, Cybulski J.S, Prakash M, D'Ambrosio M.V, Fletcher D.A, Keiser J, Andrews J.R, Bogoch I.I. Diagnosis of Schistosoma haematobium infection with a mobile phone-mounted foldscope and a reversed-lens CellScope in Ghana. Am J Trop Med Hyg. 2015;92(6):1253-1256. DOI: 10.4269/ajtmh.14-0741

Frahm S, Loffredo-Verde E, Bhattacherjee S, Luo S, Formichella L, Keiser J, Verschoor A, Da Costa C.U.P. The influence of host serum factors on the development of S. mansoni in its definite host. Trop Med Int Health, 2015;20(Suppl. 1):236. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Hess J, Keiser J, Gasser G. Toward organometallic antischistosomal drug candidates. Future Med Chem. 2015;7(6):821-830. DOI: 10.4155/fmc.15.22

Keiser J, Panic G, Vargas M, Wang C, Dong Y, Gautam N, Vennerstrom J.L. Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal. J Antimicrob Chemother. 2015;70(6):1788-1797. DOI: 10.1093/jac/dkv016

Keiser J. Is Caenorhabditis elegans the magic bullet for anthelminthic drug discovery?. Trends Parasitol. 2015;31(10):455-456. DOI: 10.1016/j.pt.2015.08.004

Kovac J, Leonidova A, Meister I, Panic G, Coulibaly J, Huwyler J, Keiser J. Praziquantel dose-finding and pharmacokinetic studies in school-and preschool-aged children infected with S-mansoni. Trop Med Int Health, 2015;20(Suppl. 1):229. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Meister I, Vanobberghen F, Penny M.A, Sayasone S, Phongluxa K, Odermatt P, Duthaler U, Leonidova A, Huwyler J, Keiser J. Population pharmacokinetics of the novel anthelminthic tribendimidine in Opisthorchis viverrini infected patients in Lao PDR. Trop Med Int Health, 2015;20(Suppl. 1):303. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Ogorodova L.M, Fedorova O.S, Sripa B, Mordvinov V.A, Katokhin A.V, Keiser J, Odermatt P, Brindley P.J, Mayboroda O.A, Velavan T.P, Freidin M.B, Sazonov A.E, Saltykova I.V, Pakharukova M.Y, Kovshirina Y.V, Kaloulis K, Krylova O.Y, Yazdanbakhsh M. Opisthorchiasis: an overlooked danger. PLoS Negl Trop Dis. 2015;9(4):e0003563. DOI: 10.1371/journal.pntd.0003563

Olliaro P.L, Vaillant M, Diawara A, Coulibaly J.T, Garba A, Keiser J, King C.H, Knopp S, Landoure A, N'Goran E.K, Raso G, Scherrer A.U, Sousa-Figueiredo J.C, Stete K, Zhou X.N, Utzinger J. Toward measuring Schistosoma response to praziquantel treatment with appropriate descriptors of egg excretion. PLoS Negl Trop Dis. 2015;9(6):e0003821. DOI: 10.1371/journal.pntd.0003821

Olliaro P.L, Vaillant M.T, Diawara A, Coulibaly J.T, Garba A, Keiser J, King C.H, Knopp S, Landoure A, N'Goran E.K, Raso G, Scherrer A.U, Sousa-Figueiredo J.C, Stete K, Zhou X.N, Utzinger J, Speich B, Albonico M, Halpenny C, Kihara J, Prichard R.K. How to measure responses to anthelmintic treatments? Centile distribution of individual versus group mean egg reduction rates. Trop Med Int Health, 2015;20(Suppl. 1):304-305

Panic G, Flores D, Ingram-Sieber K, Keiser J. Fluorescence/luminescence-based markers for the assessment of Schistosoma mansoni schistosomula drug assays. Parasit Vectors. 2015;8:624. DOI: 10.1186/s13071-015-1233-3

Panic G, Vargas M, Scandale I, Keiser J. Investigations of an FDA-approved compound library for potential drugs against Schistosoma mansoni. Trop Med Int Health, 2015;20(Suppl. 1):235-236. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Panic G, Vargas M, Scandale I, Keiser J. Activity profile of an FDA-approved compound library against Schistosoma mansoni. PLoS Negl Trop Dis. 2015;9(7):e0003962. DOI: 10.1371/journal.pntd.0003962

Sayasone S, Keiser J, Vonghachack Y, Xayavong S, Senggnam K, Meister I, Hattendorf J, Akkhavong K, Odermatt P. Tribendimidine is an efficacious and safe drug against Opisthorchis viverrini: results of a randomized controlled trial in southern Lao PDR. Trop Med Int Health, 2015;20(Suppl. 1):28-29. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Speich B, Ali S.M, Ame S.M, Albonico M, Utzinger J, Keiser J. Quality control in the diagnosis of Trichuris trichiura and Ascaris lumbricoides using the Kato-Katz technique: experience from three randomised controlled trials. Parasit Vectors. 2015;8:82. DOI: 10.1186/s13071-015-0702-z

Speich B, Ali S.M, Ame S.M, Bogoch I.I, Alles R, Huwyler J, Albonico M, Hattendorf J, Utzinger J, Keiser J. Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised con. Lancet Infect Dis. 2015;15(3):277-284. DOI: 10.1016/S1473-3099(14)71050-3

Vejzagic N, Adelfio R, Keiser J, Kringel H, Thamsborg S.M, Kapel C.M. Bacteria-induced egg hatching differs for Trichuris muris and Trichuris suis. Parasit Vectors. 2015;8:371. DOI: 10.1186/s13071-015-0986-z

Bogoch I.I, Andrews J.R, Speich B, Ame S.M, Ali S.M, Stothard J.R, Utzinger J, Keiser J. Quantitative evaluation of a handheld light microscope for field diagnosis of soil-transmitted helminth infection. Am J Trop Med Hyg. 2014;91(6):1138-1141. DOI: 10.4269/ajtmh.14-0253

Bogoch I.I, Coulibaly J.T, Andrews J.R, Speich B, Keiser J, Stothard J.R, N'Goran E.K, Utzinger J. Evaluation of portable microscopic devices for the diagnosis of Schistosoma and soil-transmitted helminth infection. Parasitology. 2014;141(14):1811-1818. DOI: 10.1017/S0031182014000432

Gasser G, Patra M, Ingram K, Keiser J. Towards novel organometallic-based anthelmintic drug candidates. J Biol Inorg Chem, 2014;19(1):S180

Hotez P.J, Alvarado M, Basanez M.G, Bolliger I, Bourne R, Boussinesq M, Brooker S.J, Brown A.S, Buckle G, Budke C.M, Carabin H, Coffeng L.E, Fevre E.M, Fürst T, Halasa Y.A, Jasrasaria R, Johns N.E, Keiser J, King C.H, Lozano R, Murdoch M.E, O'Hanlon S, Pion S.D, Pullan R.L, Ramaiah K.D, Roberts T, Shepard D.S, Smith J.L, Stolk W.A, Undurraga E.A, Utzinger J, Wang M, Murray C.J, Naghavi M. The global burden of disease study 2010: interpretation and implications for the neglected tropical diseases. PLoS Negl Trop Dis. 2014;8(7):e2865. DOI: 10.1371/journal.pntd.0002865

Ingram-Sieber K, Cowan N, Panic G, Vargas M, Mansour N.R, Bickle Q.D, Wells T.N, Spangenberg T, Keiser J. Orally active antischistosomal early leads identified from the open access malaria box. PLoS Negl Trop Dis. 2014;8(1):e2610. DOI: 10.1371/journal.pntd.0002610