Publications

Holzschuh A, Lerch A, Fakih B.S, Aliy S.M, Ali M.H, Ali M.A, Bruzzese D.J, Yukich J, Hetzel M.W, Koepfli C. Using a mobile nanopore sequencing lab for end-to-end genomic surveillance of Plasmodium falciparum: a feasibility study. PLOS Glob Public Health. 2024;4(2):e0002743. DOI: 10.1371/journal.pgph.0002743

Brunner N.C, Karim A, Athieno P, Kimera J, Tumukunde G, Angiro I, Signorell A, Delvento G, Lee T.T, Lambiris M, Ogwal A, Nakiganda J, Mpanga F, Kagwire F, Amutuhaire M, Burri C, Lengeler C, Awor P, Hetzel M.W. Starting at the community: treatment-seeking pathways of children with suspected severe malaria in Uganda. PLOS Glob Public Health. 2023;3(7):e0001949. DOI: 10.1371/journal.pgph.0001949

Das A.M, Hetzel M.W, Yukich J.O, Stuck L, Fakih B.S, Al-mafazy A.H, Ali A, Chitnis N. Modelling the impact of interventions on imported, introduced and indigenous malaria infections in Zanzibar, Tanzania. Nat Commun. 2023;14:2750. DOI: 10.1038/s41467-023-38379-8

Fakih B.S, Holzschuh A, Ross A, Stuck L, Abdul R, Al-mafazy A.H, Irema I, Mbena A, Thawer S.G, Shija S.J, Aliy S.M, Ali A, Fink G, Yukich J, Hetzel M.W. Risk of imported malaria infections in Zanzibar: a cross-sectional study. Infect Dis Poverty. 2023;12:80. DOI: 10.1186/s40249-023-01129-5

Golumbeanu M, Edi C.A.V, Hetzel M.W, Koepfli C, Nsanzabana C. Bridging the gap from molecular surveillance to programmatic decisions for malaria control and elimination. Am J Trop Med Hyg. 2023(in press). DOI: 10.4269/ajtmh.22-0749

Hetzel M.W, Awor P, Tshefu A, Omoluabi E, Burri C, Signorell A, Lambiris M.J, Visser T, Cohen J.M, Buj V, Lengeler C. Pre-referral rectal artesunate: no cure for unhealthy systems. Lancet Infect Dis. 2023;23(6):e213-e217. DOI: 10.1016/S1473-3099(22)00762-9

Hetzel M.W, Okitawutshu J, Tshefu A, Omoluabi E, Awor P, Signorell A, Kwiatkowski M, Lambiris M.J, Visser T, Cohen J.M, Buj V, Burri C, Lengeler C. Pre-referral rectal artesunate is no "magic bullet" in weak health systems. BMC Med. 2023;21:119. DOI: 10.1186/s12916-023-02777-y

Holzschuh A, Lerch A, Gerlovina I, Fakih B.S, Al-mafazy A.H, Reaves E.J, Ali A, Abbas F, Ali M.H, Ali M.A, Hetzel M.W, Yukich J, Koepfli C. Multiplexed ddPCR-amplicon sequencing reveals isolated Plasmodium falciparum populations amenable to local elimination in Zanzibar, Tanzania. Nat Commun. 2023;14:3699. DOI: 10.1038/s41467-023-39417-1

Lambiris M.J, Venga G.N, Ssempala R, Balogun V, Galactionova K, Musiitwa M, Kagwire F, Olosunde O, Emedo E, Luketa S, Sangare M, Buj V, Delvento G, Tshefu A, Okitawutshu J, Omoluabi E, Awor P, Signorell A, Hetzel M.W, Lee T.T, Brunner N.C, Cereghetti N, Visser T, Napier H.G, Burri C, Lengeler C. Health system readiness and the implementation of rectal artesunate for severe malaria in sub-Saharan Africa: an analysis of real-world costs and constraints. Lancet Glob Health. 2023;11(2):e256-e264. DOI: 10.1016/S2214-109X(22)00507-1

Mäser P, Bernhard S, Brun R, Burri C, Gagneux S, Hetzel M.W, Kaiser M, Lengeler C, Pluschke G, Reus E, Rottmann M, Utzinger J, Warryn L, Wittlin S, Keiser J. Key contributions by the Swiss Tropical and Public Health Institute towards new and better drugs for tropical diseases. Chimia (Aarau). 2023;77(9):593-606. DOI: 10.2533/chimia.2023.593

Okitawutshu J, Tshefu A, Kalenga J.C, Delvento G, Burri C, Hetzel M.W, Lengeler C, Signorell A. Assessing caregivers' perceptions of treatment-seeking for suspected severe malaria in the Democratic Republic of the Congo. Malar J. 2023;22:308. DOI: 10.1186/s12936-023-04737-6

Signorell A, Awor P, Okitawutshu J, Tshefu A, Omoluabi E, Hetzel M.W, Athieno P, Kimera J, Tumukunde G, Angiro I, Kalenga J.C, Akano B.K, Ayodeji K, Okon C, Yusuf O, Delvento G, Lee T.T, Brunner N.C, Lambiris M.J, Okuma J, Cereghetti N, Buj V, Visser T, Napier H.G, Lengeler C, Burri C. Health worker compliance with severe malaria treatment guidelines in the context of implementing pre-referral rectal artesunate in the Democratic Republic of the Congo, Nigeria, and Uganda: an operational study. PLoS Med. 2023;20(2):e1004189. DOI: 10.1371/journal.pmed.1004189

Awor P, Kimera J, Athieno P, Tumukunde G, Okitawutshu J, Tshefu A, Omoluabi E, Signorell A, Brunner N, Kalenga J.C, Akano B, Ayodeji K, Okon C, Yusuf O, Delvento G, Lee T, Burri C, Lengeler C, Hetzel M.W. Acceptability of pre-referral rectal artesunate for severe malaria in children under 5 years by health workers and caregivers in the Democratic Republic of the Congo, Nigeria and Uganda. Malar J. 2022;21:322. DOI: 10.1186/s12936-022-04348-7

Awor P, Kimera J, Brunner N.C, Athieno P, Tumukunde G, Angiro I, Signorell A, Delvento G, Lee T, Amutuhaire M, Opigo J, Kaggwa F.M, Kagwire F, Nakiganda J, Burri C, Lengeler C, Hetzel M.W. Care seeking and treatment of febrile children with and without danger signs of severe disease in northern Uganda: results from three household surveys (2018-2020). Am J Trop Med Hyg. 2022;107(4):934–938. DOI: 10.4269/ajtmh.21-1132

Brunner N.C, Omoluabi E, Awor P, Okitawutshu J, Tshefu Kitoto A, Signorell A, Akano B, Ayodeji K, Okon C, Yusuf O, Athieno P, Kimera J, Tumukunde G, Angiro I, Kalenga J.C, Delvento G, Lee T.T, Lambiris M.J, Ross A, Cereghetti N, Visser T, Napier H.G, Buj V, Burri C, Lengeler C, Hetzel M.W. Prereferral rectal artesunate and referral completion among children with suspected severe malaria in the Democratic Republic of the Congo, Nigeria and Uganda. BMJ Glob Health. 2022;7(5):e008346. DOI: 10.1136/bmjgh-2021-008346

Cleary E, Hetzel M.W, Clements A.C.A. A review of malaria epidemiology and control in Papua New Guinea 1900 to 2021: progress made and future directions. Front Epidemiol. 2022;2:980795. DOI: 10.3389/fepid.2022.980795

Das A.M, Hetzel M.W, Yukich J.O, Stuck L, Fakih B.S, Al-mafazy A.H, Ali A, Chitnis N. The impact of reactive case detection on malaria transmission in Zanzibar in the presence of human mobility. Epidemics. 2022;41:100639. DOI: 10.1016/j.epidem.2022.100639

Giduthuri J.G, Kualawi M, Muri M, Are C, Goi P, Minn Oo M, Hetzel M.W, Pomat W. Papua New Guinea national health facility survey 2021: availability and quality of malaria case management. Goroka: Papua New Guinea Institute of Medical Research, 2022

Hetzel M.W, Okitawutshu J, Tshefu A, Omoluabi E, Awor P, Signorell A, Brunner N.C, Kalenga J.C, Akano B.K, Ayodeji K, Okon C, Yusuf O, Athieno P, Kimera J, Tumukunde G, Angiro I, Delvento G, Lee T.T, Lambiris M.J, Kwiatkowski M, Cereghetti N, Visser T, Napier H.G, Cohen J.M, Buj V, Burri C, Lengeler C. Effectiveness of rectal artesunate as pre-referral treatment for severe malaria in children under 5 years of age: a multi-country observational study. BMC Med. 2022;20:343. DOI: 10.1186/s12916-022-02541-8

Keven J.B, Katusele M, Vinit R, Rodríguez-Rodríguez D, Hetzel M.W, Robinson L.J, Laman M, Karl S, Walker E.D. Vector composition, abundance, biting patterns and malaria transmission intensity in Madang, Papua New Guinea: assessment after 7 years of an LLIN-based malaria control programme. Malar J. 2022;21:7. DOI: 10.1186/s12936-021-04030-4

Lengeler C, Burri C, Awor P, Athieno P, Kimera J, Tumukunde G, Angiro I, Tshefu A, Okitawutshu J, Kalenga J.-C, Omoluabi E, Akano B, Ayodeji K, Okon C, Yusuf O, Brunner N.C, Delvento G, Lee T, Lambiris M.J, Visser T, Napier H.G, Cohen J.M, Buj V, Signorell A, Hetzel Manuel W, Caramal Consortium. Community access to rectal artesunate for malaria (CARAMAL): a large-scale observational implementation study in the Democratic Republic of the Congo, Nigeria and Uganda. PLoS Glob Public Health. 2022;2(9):e0000464. DOI: 10.1371/journal.pgph.0000464

Namango I.H, Marshall C, Saddler A, Ross A, Kaftan D, Tenywa F, Makungwa N, Odufuwa O.G, Ligema G, Ngonyani H, Matanila I, Bharmal J, Moore J, Moore S.J, Hetzel M.W. The Centres for Disease Control light trap (CDC-LT) and the human decoy trap (HDT) compared to the human landing catch (HLC) for measuring Anopheles biting in rural Tanzania. Malar J. 2022;21:181. DOI: 10.1186/s12936-022-04192-9

Naung M.T, Martin E, Munro J, Mehra S, Guy A.J, Laman M, Harrison G.L.A, Tavul L, Hetzel M, Kwiatkowski D, Mueller I, Bahlo M, Barry A.E. Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens. PLoS Comput Biol. 2022;18(2):e1009801. DOI: 10.1371/journal.pcbi.1009801

Okitawutshu J, Signorell A, Kalenga J.C, Mukomena E, Delvento G, Burri C, Mwaluke F, Buj V, Sangare M, Luketa S, Brunner N, Lee T, Hetzel M, Lengeler C, Tshefu A. Key factors predicting suspected severe malaria case management and health outcomes: an operational study in the Democratic Republic of the Congo. Malar J. 2022;21:274. DOI: 10.1186/s12936-022-04296-2

Seidahmed O, Jamea S, Kurumop S, Timbi D, Makita L, Ahmed M, Freeman T, Pomat W, Hetzel M.W. Stratification of malaria incidence in Papua New Guinea (2011–2019): contribution towards a sub-national control policy. PLoS Glob Public Health. 2022;2(11):e0000747. DOI: 10.1371/journal.pgph.0000747

Vera-Arias C.A, Holzschuh A, Oduma C.O, Badu K, Abdul-Hakim M, Yukich J, Hetzel M.W, Fakih B.S, Ali A, Ferreira M.U, Ladeia-Andrade S, Sáenz F.E, Afrane Y, Zemene E, Yewhalaw D, Kazura J.W, Yan G, Koepfli C. High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy. eLife. 2022;11:e72083. DOI: 10.7554/eLife.72083

Awor P, Khim N, Coppée R, Rondepierre L, Roesch C, Khean C, Kul C, Eam R, Lorn T, Athieno P, Kimera J, Clain J, Ringwald P, Signorell A, Lengeler C, Burri C, Ariey F, Hetzel M.W, Witkowski B. Clonal expansion of artemisinin-resistant Plasmodium falciparum in Uganda is associated with substandard treatment practices. Lancet. 2021(in press). DOI: 10.2139/ssrn.3974542

Brunner N.C, Awor P, Hetzel M.W. Definitions of severity in treatment seeking studies of febrile illness in children in low and middle income countries: a scoping review. Int J Public Health. 2021;66:634000. DOI: 10.3389/ijph.2021.634000

Cleary E, Hetzel M.W, Siba P, Lau C.L, Clements A.C.A. Spatial prediction of malaria prevalence in Papua New Guinea: a comparison of Bayesian decision network and multivariate regression modelling approaches for improved accuracy in prevalence prediction. Malar J. 2021;20:269. DOI: 10.1186/s12936-021-03804-0

Cleary E, Hetzel M.W, Siba P.M, Lau C.L, Clements A.C.A. Correction to: Spatial prediction of malaria prevalence in Papua New Guinea: a comparison of Bayesian decision network and multivariate regression modelling approaches for improved accuracy in prevalence prediction. Malar J. 2021;20:318. DOI: 10.1186/s12936-021-03838-4

Gul D, Rodríguez-Rodríguez D, Nate E, Auwan A, Salib M, Lorry L, Keven J.B, Katusele M, Rosado J, Hofmann N, Ome-Kaius M, Koepfli C, Felger I, Kazura J.W, Hetzel M.W, Mueller I, Karl S, Clements A.C.A, Fowkes F.J.I, Laman M, Robinson L.J. Investigating differences in village-level heterogeneity of malaria infection and household risk factors in Papua New Guinea. Sci Rep. 2021;11:16540. DOI: 10.1038/s41598-021-95959-8

Keven J.B, Katusele M, Vinit R, Rodríguez-Rodríguez D, Hetzel M.W, Robinson L.J, Laman M, Karl S, Foran D.R, Walker E.D. Nonrandom selection and multiple blood feeding of human hosts by Anopheles vectors: implications for malaria transmission in Papua New Guinea. Am J Trop Med Hyg. 2021;105(6):1747-1758. DOI: 10.4269/ajtmh.21-0210

Lautu-Gumal D, Razook Z, Koleala T, Nate E, McEwen S, Timbi D, Hetzel M.W, Lavu E, Tefuarani N, Makita L, Kazura J, Mueller I, Pomat W, Laman M, Robinson L.J, Barry A.E. Surveillance of molecular markers of Plasmodium falciparum artemisinin resistance (kelch13 mutations) in Papua New Guinea between 2016 and 2018. Int J Parasitol Drugs Drug Resist. 2021;16:188-193. DOI: 10.1016/j.ijpddr.2021.06.004

Lee T.T, Omoluabi E, Ayodeji K, Yusuf O, Okon C, Brunner N.C, Delvento G, Signorell A, Lambiris M, Kwiatkowski M, Burri C, Lengeler C, Emedo E, Cheshi F, Hetzel M.W. Treatment-seeking for children with suspected severe malaria attending community health workers and primary health centres in Adamawa State, Nigeria. medRxiv. 2021(in press). DOI: 10.1101/2021.12.01.21267130

Rodríguez-Rodríguez D, Katusele M, Auwun A, Marem M, Robinson L.J, Laman M, Hetzel M.W, Pulford J. Human behavior, livelihood, and malaria transmission in two sites of Papua New Guinea. J Infect Dis. 2021;223(Suppl. 2):S171-S186. DOI: 10.1093/infdis/jiaa402

Seidahmed O.M.E, Kurumop S, Jamea-Maiasa S, Timbi D, Tandrapah A, Hetzel M, Pomat W. Papua New Guinea malaria indicator survey 2019-2020: final report on malaria prevention, infection prevalence, and treatment-seeking. Goroka: Papua New Guinea Institute of Medical Research, PNGIMR, 2021

Grossenbacher B, Holzschuh A, Hofmann N.E, Omar K.A, Stuck L, Fakih B.S, Ali A, Yukich J, Hetzel M.W, Felger I. Molecular methods for tracking residual Plasmodium falciparum transmission in a close-to-elimination setting in Zanzibar. Malar J. 2020;19:50. DOI: 10.1186/s12936-020-3127-x

Hetzel M. PNG’s health data: too much of a good thing – part two. Australia: Devpolicy Blog, 2020

Hetzel M. PNG’s health data: too much of a good thing – part one. Australia: Devpolicy Blog, 2020

Hetzel M.W, Bonfoh B. Towards more balanced representation in Lancet commissions. Lancet. 2020;395(10238):1693-1694. DOI: 10.1016/S0140-6736(20)30617-6

Hetzel M.W, Chitnis N. Reducing malaria transmission with reactive focal interventions. Lancet. 2020;395(10233):1317-1319. DOI: 10.1016/S0140-6736(20)30678-4

Miotto O, Sekihara M, Tachibana S.I, Yamauchi M, Pearson R.D, Amato R, Goncalves S, Mehra S, Noviyanti R, Marfurt J, Auburn S, Price R.N, Mueller I, Ikeda M, Mori T, Hirai M, Tavul L, Hetzel M.W, Laman M, Barry A.E, Ringwald P, Ohashi J, Hombhanje F, Kwiatkowski D.P, Mita T. Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea. PLoS Pathog. 2020;16(12):e1009133. DOI: 10.1371/journal.ppat.1009133

Stuck L, Fakih B.S, Al-mafazy A.H, Hofmann N.E, Holzschuh A, Grossenbacher B, Bennett A, Cotter C, Reaves E, Ali A, Van der Horst T, Felger I, Hetzel M.W, Yukich J. Malaria infection prevalence and sensitivity of reactive case detection in Zanzibar. Int J Infect Dis. 2020;97:337-346. DOI: 10.1016/j.ijid.2020.06.017

Van der Horst T, Al-mafazy A.W, Fakih B.S, Stuck L, Ali A, Yukich J, Hetzel M.W. Operational coverage and timeliness of reactive case detection for malaria elimination in Zanzibar, Tanzania. Am J Trop Med Hyg. 2020;102(2):298-306. DOI: 10.4269/ajtmh.19-0505

Brunner N.C, Chacky F, Mandike R, Mohamed A, Runge M, Thawer S.G, Ross A, Vounatsou P, Lengeler C, Molteni F, Hetzel M.W. The potential of pregnant women as a sentinel population for malaria surveillance. Malar J. 2019;18:370. DOI: 10.1186/s12936-019-2999-0

Evaluation Task Force of Roll Back Malaria’s Monitoring and Evaluation Reference Group. Framework for evaluating national malaria programs in moderate and low transmission settings. Chapel Hill, NC, USA: MEASURE Evaluation, 2019

Rodriguez-Rodriguez D, Maraga S, Jamea-Maiasa S, Tandrapah A, Makita L, Siba P.M, Mueller I, Pulford J, Hetzel M. Mapping routine malaria incidence at village level for targeted control in Papua New Guinea. Geospat Health. 2019;14(2):357-360. DOI: 10.4081/gh.2019.798

Rodriguez-Rodriguez D, Maraga S, Lorry L, Robinson L.J, Siba P.M, Mueller I, Pulford J, Ross A, Hetzel M.W. Repeated mosquito net distributions, improved treatment, and trends in malaria cases in sentinel health facilities in Papua New Guinea. Malar J. 2019;18:364. DOI: 10.1186/s12936-019-2993-6

Fola A.A, Nate E, Harrison G.L.A, Barnades C, Hetzel M.W, Iga J, Siba P, Mueller I, Barry A.E. Nationwide genetic surveillance of Plasmodium vivax in Papua New Guinea reveals heterogeneous transmission dynamics and routes of migration amongst subdivided populations. Infect Genet Evol. 2018;58:83-95. DOI: 10.1016/j.meegid.2017.11.028

Hetzel M. Management of severe malaria cases learnings and challenges from the field. 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene. New Orlean, USA: The American Society of Tropical Medicine and Hygiene, 2018

Hetzel M.W, Genton B. Mass drug administration for malaria elimination: do we understand the settings well enough?. BMC Med. 2018;16:239. DOI: 10.1186/s12916-018-1230-4

Hetzel M.W, Saweri O.P.M, Kuadima J.J, Smith I, Ura Y, Tandrapah A, Jamea-Maiasa S, Siba P.M, Pulford J. Papua New Guinea malaria indicator survey 2016-2017: malaria prevention, infection and treatment. Goroka: Papua New Guinea Institute of Medical Research, 2018

Koimbu G, Czeher C, Katusele M, Sakur M, Kilepak L, Tandrapah A, Hetzel M.W, Pulford J, Robinson L, Karl S. Status of insecticide resistance in Papua New Guinea: an update from nation-wide monitoring of anopheles mosquitoes. Am J Trop Med Hyg. 2018;98(1):162-165. DOI: 10.4269/ajtmh.17-0454

Lengeler C, Hetzel M, Signorell A, Awor P, Tshefu A, Okitawutshu J, Omoluabi E, Nepomnyashchiy L, Fast J, Ramachandra S, Goldstein R, Buj V, Burri C. Introducing rectal artesunate in community settings and evaluating its impact. 7th MIM Pan African Malaria Conference. Dakar, Senegal, 2018

Pulford J, Kurumop S, Mueller I, Siba P.M, Hetzel M.W. The impact of the scale-up of malaria rapid diagnostic tests on the routine clinical diagnosis procedures for febrile illness: a series of repeated cross-sectional studies in Papua New Guinea. Malar J. 2018;17:202. DOI: 10.1186/s12936-018-2351-0

Pulford J, Saweri O.P.M, Jeffery C, Siba P.M, Mueller I, Hetzel M.W. Does test-based prescription of evidence-based treatment for malaria improve treatment seeking and satisfaction? Findings of repeated cross-sectional surveys in Papua New Guinea. BMJ Glob Health. 2018;3(6):e000915. DOI: 10.1136/bmjgh-2018-000915

Signorell A, Hetzel M, Awor P, Tshefu A, Okitawutshu J, Omoluabi E, Nepomnyashchiy L, Burri C, Lengeler C. CARAMAL: addressing the remaining burden of malaria deaths by optimizing the use of rectla artesunate. 7th MIM Pan African Malaria Conference. Dakar, Senegal, 2018

Tavul L, Hetzel M.W, Teliki A, Walsh D, Kiniboro B, Rare L, Pulford J, Siba P.M, Karl S, Makita L, Robinson L, Kattenberg J.H, Laman M, Oswyn G, Mueller I. Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated malaria in Papua New Guinea. Malar J. 2018;17:350. DOI: 10.1186/s12936-018-2494-z

White M.T, Walker P, Karl S, Hetzel M.W, Freeman T, Waltmann A, Laman M, Robinson L.J, Ghani A, Mueller I. Mathematical modelling of the impact of expanding levels of malaria control interventions on Plasmodium vivax. Nat Commun. 2018;9(1):3300. DOI: 10.1038/s41467-018-05860-8

Fola A.A, Abby Harrison G.L, Hazairin M.H, Barnadas C, Hetzel M.W, Iga J, Siba P.M, Mueller I, Barry A.E. Higher complexity of infection and genetic diversity of Plasmodium vivax than Plasmodium falciparum across all malaria transmission zones of Papua New Guinea. Am J Trop Med Hyg. 2017;96(3):630-641. DOI: 10.4269/ajtmh.16-0716

Hetzel M.W, Pulford J, Ura Y, Jamea-Maiasa S, Tandrapah A, Tarongka N, Lorry L, Robinson L.J, Lilley K, Makita L, Siba P.M, Mueller I. Insecticide-treated nets and malaria prevalence, Papua New Guinea, 2008–2014. Bull World Health Organ. 2017;95:695-705. DOI: 10.2471/BLT.16.189902

Koimbu G, Czeher C, Tandrapah A, Siba P, Hetzel M, Pulford J, Robinson L, Karl S. Insecticide resistance monitoring: report on phenotypic resistance of anophelines to deltamethrin, lambda-cyhalothrin and DDT (2016). Goroka: Papa New Guinea Institute of Medical Research, 2017

Kuadima J.J, Timinao L, Naidi L, Tandrapah A, Hetzel M.W, Czeher C, Pulford J. Long-term acceptability, durability and bio-efficacy of ZeroVector® durable lining for vector control in Papua New Guinea. Malar J. 2017;16:93. DOI: 10.1186/s12936-017-1742-y

Saweri O.P, Hetzel M.W, Mueller I, Siba P.M, Pulford J. The treatment of non-malarial febrile illness in Papua New Guinea: findings from cross sectional and longitudinal studies of health worker practice. BMC Health Serv Res. 2017;17:10. DOI: 10.1186/s12913-016-1965-6

Thomsen E.K, Koimbu G, Pulford J, Jamea-Maiasa S, Ura Y, Keven J.B, Siba P.M, Mueller I, Hetzel M.W, Reimer L.J. Mosquito behavior change after distribution of bednets results in decreased protection against malaria exposure. J Infect Dis. 2017;215(5):790-797. DOI: 10.1093/infdis/jiw615

Hetzel M.W, Reimer L.J, Gideon G, Koimbu G, Barnadas C, Makita L, Siba P.M, Mueller I. Changes in malaria burden and transmission in sentinel sites after the roll-out of long-lasting insecticidal nets in Papua New Guinea. Parasit Vectors. 2016;9:340. DOI: 10.1186/s13071-016-1635-x

Kurumop S.F, Tandrapah A, Hetzel M.W, Siba P.M, Mueller I, Pulford J. The Papua New Guinea national malaria control program: health facility surveys 2010-2016. Goroka: Papua New Guinea Institute of Medical Research, 2016

Ménard D, Khim N, Beghain J, Adegnika A.A, Shafiul-Alam M, Amodu O, Rahim-Awab G, Barnadas C, Berry A, Boum Y, Bustos M.D, Cao J, Chen J.H, Collet L, Cui L, Thakur G.D, Dieye A, Djalle D, Dorkenoo M.A, Eboumbou-Moukoko C.E, Espino F.E, Fandeur T, Ferreira-da-Cruz M.F, Fola A.A, Fuehrer H.P, Hassan A.M, Herrera S, Hongvanthong B, Houze S, Ibrahim M.L, Jahirul-Karim M, Jiang L, Kano S, Ali-Khan W, Khanthavong M, Kremsner P.G, Lacerda M, Leang R, Leelawong M, Li M, Lin K, Mazarati J.B, Menard S, Morlais I, Muhindo-Mavoko H, Musset L, Na-Bangchang K, Nambozi M, Niare K, Noedl H, Ouedraogo J.B, Pillai D.R, Pradines B, Quang-Phuc B, Ramharter M, Randrianarivelojosia M, Sattabongkot J, Sheikh-Omar A, Silue K.D, Sirima S.B, Sutherland C, Syafruddin D, Tahar R, Tang L.H, Toure O.A, Tshibangu-wa-Tshibangu P, Vigan-Womas I, Warsame M, Wini L, Zakeri S, Kim S, Eam R, Berne L, Khean C, Chy S, Ken M, Loch K, Canier L, Duru V, Legrand E, Barale J.C, Stokes B, Straimer J, Witkowski B, Fidock D.A, Rogier C, Ringwald P, Ariey F, Mercereau-Puijalon O, Karma Consortium. A worldwide map of Plasmodium falciparum K13-propeller polymorphisms. N Engl J Med. 2016;374(25):2453-2464. DOI: 10.1056/NEJMoa1513137

Pulford J, Smith I, Mueller I, Siba P.M, Hetzel M.W. Health worker compliance with a 'test and treat' malaria case management protocol in Papua New Guinea. PLoS One. 2016;11(7):e0158780. DOI: 10.1371/journal.pone.0158780

Reimer L.J, Thomsen E.K, Koimbu G, Keven J.B, Mueller I, Siba P.M, Kazura J.W, Hetzel M.W, Zimmerman P.A. Malaria transmission dynamics surrounding the first nationwide long-lasting insecticidal net distribution in Papua New Guinea. Malar J. 2016;15:25. DOI: 10.1186/s12936-015-1067-7

Tavul L, Hetzel M.W, Siba P, Makita L, Karl S, Pulford J, Mueller I. The efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated malaria in Papua New Guinea: 2012-2014. Papua New Guinea: Papua New Guinea Institute of Medical Research, 2016

Hetzel M.W, Morris H, Tarongka N, Barnadas C, Pulford J, Makita L, Siba P.M, Mueller I. Prevalence of malaria across Papua New Guinea after initial roll-out of insecticide-treated mosquito nets. Trop Med Int Health. 2015;20(12):1745-1755. DOI: 10.1111/tmi.12616

Hetzel M.W, Pulford J, Timbi D, Koimbu G, Barnadas C, Siba P.M, Mueller I. Dynamic changes in prevalence and incidence of malaria after intensifying control across Papua New Guinea. Trop Med Int Health, 2015;20(Suppl. 1):26

Pulford J, Smith J, Mueller I, Siba P.M, Hetzel M.W. Impact of changed fever case management practice on patients' self-reported treatment experience. Trop Med Int Health, 2015;20(Suppl. 1):417-418. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Pulford J, Tandrapah A, Siba P.M, Mueller I, Hetzel M.W. Report on time-trend data derived from malaria rapid diagnostic testing in sentinel health facilities, 2008-2015 (PNGIMR Malaria Sentinel Surveillance Program). Goroka: Papua New Guinea Institute of Medical Research, 2015

Roll Back Malaria Partnership. Action and investment to defeat malaria 2016-2030: for a malaria-free world. Geneva: World Health Organization, 2015

Angwin A, Hetzel M.W, Mueller I, Siba P.M, Pulford J. A qualitative study of how affected individuals or their caregivers respond to suspected malaria infection in rural Papua New Guinea. PNG Med J. 2014;57(1-4):30-38

Bande G, Hetzel M.W, Iga J, Barnadas C, Mueller I, Siba P.M, Horwood P.F. An investigation into febrile illnesses of unknown aetiology in Wipim, Papua New Guinea. PNG Med J. 2014;57(1-4):52-58

Betuela I, Robinson L, Hetzel M.W, Laman M, Siba P, Bassat Q, Mueller I. Primaquine treatment for Plasmodium vivax - an essential tool for malaria control and elimination in Papua New Guinea. PNG Med J. 2014;57(1-4):68-74

Hetzel M.W, Bala N, Pulford J, Page-Sharp M, Betuela I, Davis T.M.E, Lavu E.K. Quality of antimalarial and antibiotic medicines in the public sector in Papua New Guinea : report of an investigation of the health facility supply chain in 2011. Goroka: Papua New Guinea Institute of Medical Research, 2014

Hetzel M.W, Choudhury A.A, Pulford J, Ura Y, Whittaker M, Siba P.M, Mueller I. Progress in mosquito net coverage in Papua New Guinea. Malar J. 2014;13:242. DOI: 10.1186/1475-2875-13-242

Hetzel M.W, Page-Sharp M, Bala N, Pulford J, Betuela I, Davis T.M, Lavu E.K. Quality of antimalarial drugs and antibiotics in Papua New Guinea: a survey of the health facility supply chain. PLoS One. 2014;9(5):e96810. DOI: 10.1371/journal.pone.0096810

Hetzel M.W, Paul S, Benjamin L, Makita L, Mueller I, Siba P.M. The proportion of fevers attributable to malaria varies significantly between sites in Papua New Guinea. PNG Med J. 2014;57(1-4):39-51

Hetzel M.W, Pulford J, Gouda H, Hodge A, Siba P.M, Mueller I. The Papua New Guinea national malaria control program: primary outcome and impact indicators, 2009-2014. Goroka: Papua New Guinea Institute of Medical Research, 2014

Hetzel M.W, Pulford J, Maraga S, Bernadas C, Reimer L.J, Tavul L, Jamea-Maiasa S, Tandrapah T, Maalsen A, Makita L, Siba P.M, Mueller I. Evaluation of the Global Fund-supported National Malaria Control Program in Papua New Guinea, 2009-2014. PNG Med J. 2014;57(1-4):7-29

Hetzel M.W, Pulford J, Tandrapah T, Jamea-Maiasa S, PNGIMR MalCon Team. Tribute : missing in the line of duty. PNG Med J. 2014;57(1-4):94-102

Katusele M, Gideon G, Thomsen E, Siba P, Hetzel M.W, Reimer L. Long-lasting insecticidal nets remain efficacious after five years of use in Papua New Guinea. PNG Med J. 2014;57(1-4):86-93

Kurumop S.F, Pulford J, Mueller I, Siba P.M, Hetzel M.W. Diagnostic capacity and antimalarial availability in Papua New Guinea before the introduction of a revised national malaria treatment protocol. PNG Med J. 2014;57(1-4):59-67

Mueller I, Hetzel M.W. Malaria in Papua New Guinea 2000-2013: back from the brink, but where to now? [Editorial]. PNG Med J. 2014;57(1-4):1-6

Pulford J, Siba P.M, Mueller I, Hetzel M.W. The exit interview as a proxy measure of malaria case management practice: sensitivity and specificity relative to direct observation. BMC Health Serv Res. 2014;14:628. DOI: 10.1186/s12913-014-0628-8

Kurumop S.F, Bullen C, Whittaker R, Betuela I, Hetzel M.W, Pulford J. Improving health worker adherence to malaria treatment guidelines in Papua New Guinea: feasibility and acceptability of a text message reminder service. PLoS One. 2013;8(10):e76578. DOI: 10.1371/journal.pone.0076578

Paul S, Pulford J, Mueller I, Siba P.M, Hetzel M.W. Initial impact of long lasting insecticide treated mosquito nets on malaria in Karimui, Papua New Guinea. Am J Trop Med Hyg, 2013;89(5):392

Pulford J, Kaupa B, Kurumop S.F, Mueller I, Siba P.M, Hetzel M.W. Malaria case management in Papua New Guinea pre- and post-impementation of a revised treatment protocol. Am J Trop Med Hyg, 2013;89(5):242-243

Pulford J, Kurumop S.F, Ura Y, Siba P.M, Mueller I, Hetzel M.W. Malaria case management in Papua New Guinea following the introduction of a revised treatment protocol. Malar J. 2013;12:433. DOI: 10.1186/1475-2875-12-433

Pulford J, Saweri O, Paul S, Mueller I, Siba P, Hetzel M. The treatment of non-malaria febrile illness in Papua New Guinea: findings from cross sectional and longitudinal studies of health worker practice. Trop Med Int Health, 2013;18(Suppl. 1):108

Reimer L.J, Thomsen E.K, Tisch D.J, Henry-Halldin C.N, Zimmerman P.A, Baea M.E, Dagoro H, Susapu M, Hetzel M.W, Bockarie M.J, Michael E, Siba P.M, Kazura J.W. Insecticidal bed nets and filariasis transmission in Papua New Guinea. N Engl J Med. 2013;369(8):745-753. DOI: 10.1056/NEJMoa1207594

Betuela I, Maraga S, Hetzel M.W, Tandrapah T, Sie A, Yala S, Kundi J, Siba P, Reeder J.C, Mueller I. Epidemiology of malaria in the Papua New Guinean highlands. Trop Med Int Health. 2012;17(10):1181-1191. DOI: 10.1111/j.1365-3156.2012.03062.x

Dillip A, Alba S, Mshana C, Hetzel M, Lengeler C, Mayumana I, Schulze A, Mshinda H, Weiss M.G, Obrist B. Acceptability - a neglected dimension of access to health care: findings from a study on childhood convulsions in rural Tanzania. BMC Health Serv Res. 2012;12:113. DOI: 10.1186/1472-6963-12-113

Dillip A, Alba S, Mshana C, Hetzel M, Liana J, Lengeler C, Mayumana I, Schulze A, Mshinda H, Obrist B. Mystery shopping in community drug shops: research as development in rural Tanzania. Malar J, 2012;11(Suppl. 1):S7

Henry-Halldin C.N, Nadesakumaran K, Keven J.B, Zimmerman A.M, Siba P, Mueller I, Hetzel M.W, Kazura J.W, Thomsen E, Reimer L.J, Zimmerman P.A. Multiplex assay for species identification and monitoring of insecticide resistance in Anopheles punctulatus group populations of Papua New Guinea. Am J Trop Med Hyg. 2012;86(1):140-151. DOI: 10.4269/ajtmh.2012.11-0503

Hetzel M.W, Gideon G, Lote N, Makita L, Siba P.M, Mueller I. Ownership and usage of mosquito nets after four years of large-scale free distribution in Papua New Guinea. Malar J. 2012;11:192. DOI: 10.1186/1475-2875-11-192

Pulford J, Mueller I, Siba P.M, Hetzel M.W. Malaria case management in Papua New Guinea prior to the introduction of a revised treatment protocol. Malar J. 2012;11:157. DOI: 10.1186/1475-2875-11-157

Pulford J, Oakiva T, Angwin A, Bryant M, Mueller I, Hetzel M.W. Indifferent to disease: a qualitative investigation of the reasons why some Papua New Guineans who own mosquito nets choose not to use them. Soc Sci Med. 2012;75(12):2283-2290. DOI: 10.1016/j.socscimed.2012.08.030

Pulford J, Tandrapah A, Atkinson J.A, Kaupa B, Russell T, Hetzel M.W. Feasibility and acceptability of insecticide-treated plastic sheeting (ITPS) for vector control in Papua New Guinea. Malar J. 2012;11:342. DOI: 10.1186/1475-2875-11-342

Alba S, Hetzel M.W, Nathan R, Alexander M, Lengeler C. Assessing the impact of malaria interventions on morbidity through a community-based surveillance system. Int J Epidemiol. 2011;40(2):405-416. DOI: 10.1093/ije/dyq240

Henry-Halldin C.N, Reimer L, Thomsen E, Koimbu G, Zimmerman A, Keven J.B, Dagoro H, Hetzel M.W, Mueller I, Siba P, Zimmerman P.A. High throughput multiplex assay for species identification of Papua New Guinea malaria vectors: members of the Anopheles punctulatus (Diptera: Culicidae) species group. Am J Trop Med Hyg. 2011;84(1):166-173. DOI: 10.4269/ajtmh.2011.10-0438

Pulford J, Hetzel M.W, Bryant M, Siba P.M, Mueller I. Reported reasons for not using a mosquito net when one is available: a review of the published literature. Malar J. 2011;10:83. DOI: 10.1186/1475-2875-10-83

Alba S, Dillip A, Hetzel M.W, Mayumana I, Mshana C, Makemba A, Alexander M, Obrist B, Schulze A, Kessy F, Mshinda H, Lengeler C. Improvements in access to malaria treatment in Tanzania following community, retail sector and health facility interventions - a user perspective. Malar J. 2010;9:163. DOI: 10.1186/1475-2875-9-163

Alba S, Hetzel M.W, Goodman C, Dillip A, Liana J, Mshinda H, Lengeler C. Improvements in access to malaria treatment in Tanzania after switch to artemisinin combination therapy and the introduction of accredited drug dispensing outlets - a provider perspective. Malar J. 2010;9:164. DOI: 10.1186/1475-2875-9-164

Dillip A, Hetzel M.W, Gosoniu D, Kessy F, Lengeler C, Mayumana I, Mshana C, Mshinda H, Schulze A, Makemba A, Pfeiffer C, Weiss M.G, Obrist B. Socio-cultural factors explaining timely and appropriate use of health facilities for degedege in south-eastern Tanzania. Malar J. 2009;8:144. DOI: 10.1186/1475-2875-8-144

Hetzel M.W. An integrated approach to malaria control in Papua New Guinea. P N G Med J. 2009;52(1-2):1-7

Wiedenmayer K.A, Weiss S, Chattopadhyay C, Mukherjee A, Kundu R, Ayé R, Tediosi F, Hetzel M.W, Tanner M. Simplifying paediatric immunization with a fully liquid DTP-HepB-Hib combination vaccine: evidence from a comparative time-motion study in India. Vaccine. 2009;27(5):655-659. DOI: 10.1016/j.vaccine.2008.11.045

Hetzel M, Suter R. Malaria : eine Beilage der Basler Swiss Malaria Group Mitglieder. Basler Zeitung. 4/25/2008;Supplement

Hetzel M.W, Alba S, Fankhauser M, Mayumana I, Lengeler C, Obrist B, Nathan R, Makemba A.M, Mshana C, Schulze A, Mshinda H. Malaria risk and access to prevention and treatment in the paddies of the Kilombero Valley, Tanzania. Malar J. 2008;7:7. DOI: 10.1186/1475-2875-7-7

Hetzel M.W, Dillip A, Lengeler C, Obrist B, Msechu J.J, Makemba A.M, Mshana C, Schulze A, Mshinda H. Malaria treatment in the retail sector: knowledge and practices of drug sellers in rural Tanzania. BMC Public Health. 2008;8:157

Hetzel M.W, Obrist B, Lengeler C, Msechu J.J, Nathan R, Dillip A, Makemba A.M, Mshana C, Schulze A, Mshinda H. Obstacles to prompt and effective malaria treatment lead to low community-coverage in two rural districts of Tanzania. BMC Public Health. 2008;8:317

Hetzel M.W, Iteba N, Makemba A, Mshana C, Lengeler C, Obrist B, Schulze A, Nathan R, Dillip A, Alba S, Mayumana I, Khatib R.A, Njau J.D, Mshinda H. Understanding and improving access to prompt and effective malaria treatment and care in rural Tanzania: the ACCESS Programme. Malar J. 2007;6:83

Hetzel Manuel Wolf-Werner. Access to prompt and effective malaria treatment in the Kilombero valley, Tanzania. Basel: Univ. Basel, 2007. Doctoral Thesis, University of Basel, Faculty of Science DOI: 10.5451/unibas-004396637

Obrist B, Iteba N, Lengeler C, Makemba A, Mshana C, Nathan R, Alba S, Dillip A, Hetzel M.W, Mayumana I, Schulze A, Mshinda H. Access to health care in contexts of livelihood insecurity: a framework for analysis and action. PLoS Med. 2007;4(10):e308. DOI: 10.1371/journal.pmed.0040308

Hetzel M.W, Msechu J.J, Goodman C, Lengeler C, Obrist B, Kachur S.P, Makemba A, Nathan R, Schulze A, Mshinda H. Decreased availability of antimalarials in the private sector following the policy change from chloroquine to sulphadoxine-pyrimethamine in the Kilombero Valley, Tanzania. Malar J. 2006;5:109