Clinical Trial Expertise in Global Health
Bringing Science to Patients
With over 20 years of clinical research and operational experience, Swiss TPH has a unique expertise in clinical trials. We are dedicated to the design, implementation, management and monitoring of Phase I to Phase IV clinical trials with a focus on poverty related diseases. As both a sponsor and service provider, we understand the barriers to delivering clinical trials in difficult settings and offer strategic, customized solutions with the aim to deliver high quality data for clinical trials, putting the patient at the center of our efforts.
Our expertise lies in the development and evaluation of drugs, diagnostics and vaccines and finding novel solutions for non-communicable and neglected tropical diseases. We do this through:
- Local know-how of regional context
- Understanding of patient pathway
- Academic and scientific innovation
- Clinical expertise and management
- Global network of partners and collaborators
Through our multidisciplinary teams, large network of collaborators and local and global experts, Swiss TPH supports a diversity of clients. Our long-standing expertise allows us to continuously adapt and develop expertise from both investigator-initiated studies as well as regulatory trials. Our services include:
Trial Management of Multinational Studies
Our global, multidisciplinary clinical research professionals are dedicated to advancing clinical trials. Through our combined clinical, research and local expertise with long-standing partners in an extensive global network of regional collaborators, we support the management, conduct and monitoring of multi-center studies to deliver high-quality, consumer-focused clinical trial results.
Study Design and Adaptability
Good clinical trial design is key to optimizing study conduct. Performing clinical trials based on a sound understanding of clinical practice facilitates the implementation of evidence-based practice and adaptability. Through a multifaceted approach and diverse expertise from clinical staff, pharmacists, biologists, epidemiologists, data managers and statisticians, we aim to optimize clinical trials robustness and success.
Feasibility and Study Site Evaluation
It’s estimated that more than 90% of clinical trials fail due to poor patient recruitment, inefficient clinical investigator selection, poor understanding of ethical and local regulatory aspects of the selected site for conducting the study, cost incurred due to delays and more. Swiss TPH has been successfully facilitating the feasibility, set-up, project management and monitoring of epidemiological studies and clinical trials(Phase I-IV) in low-income settings and emerging economies for 20 years.
Strengthening Capacity Building
Through our combined clinical, research and local expertise and an extensive global network of regional collaborators, Swiss TPH embeds capacity building throughout all our projects as part of our commitment to sustainable development. In addition, we provide mentorship and training support for people at the European Centre for Clinical Research, the University of Basel and we are an active member of the WHO Special Programme for Research and Training in Tropical Diseases.
Planning and Conducting Phase I-IV Studies
Swiss TPH combines translational and clinical research to advance laboratory discovery and apply the findings within communities. By working across medical parasitology to infection biology, our researchers collaborate with international partners to bridge the gap between bench and bedside, ensuring that safe, effective and innovative treatments reach patients as quickly as possible.
Research Governance and Good Clinical Practice
Promoting evidence-based medicine and conducting clinical research requires customized solutions. We constantly enhance our quality processes and adherence to Good Clinical Practice (GCP). Continuous improvement of our processes is supported by the use of our validated clinical trial management system. Through collaboration with our partners, we offer a wide range of quality services as well as provide Swissethics validated GCP training.
Project and Clinical Study Sites
Strengthening Local Capacities
In developing countries and particularly rural areas, adequate capacities including human resources and infrastructure may not always be guaranteed to facilitate clinical trials up to regulatory standard. Maximizing safety and finding sustainable long-term solutions can translate into building infrastructure, strengthening local know-how by offering expertise, building capacity and empowering local and existing partners.
The DRC Hub
To support our growing number of projects in the Democratic Republic of the Congo (DRC), we have established and registered as an NGO in the DRC since July 2015. The office serves as the local representation of the Clinical Operations Unit and is the basis for a broad spectrum of activities in both clinical research and public health.
Swiss TPH also maintains a project office in Bukavu, supporting capacity building and research projects in the East of the DRC.
The past and current project portfolio in the DRC comprises epidemiological research projects, capacity strengthening activities in public health and malaria, clinical trials on human African trypanosomiasis (sleeping sickness) and malaria in both paediatric and adult populations. The Swiss TPH office is also the basis of the Alliance for Clinical Research and Clinical Epidemiology in the DRC (ARCEAU-RDC) and our direct link to the various partner organisations and clients in the DRC.