Diagnostic accuracy of a LAMP kit for diagnosis of imported malaria in Switzerland (Publications)
BACKGROUND: The diagnosis of acute malaria in non-endemic countries is still carried out largely by microscopic examination of thick and thin smears or rapid diagnostic tests. Low-density infections m
Impact of malaria pre-exposure on anti-parasite cellular and humoral immune responses after controlled human malaria infection (Publications)
To understand the effect of previous malaria exposure on anti-parasite immune responses is important for developing successful immunization strategies. Controlled human malaria infections (CHMI) using
Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents (Publications)
The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent
Maximizing microscopy as a diagnostic tool in peripheral health centres of BU endemic areas in Ghana (Publications)
BACKGROUND: Buruli ulcer (BU) disease, a skin condition caused by Mycobacterium ulcerans (M. ulcerans) is endemic in remote rural areas. Disease diagnosis on clinical basis alone can be misleading, re
Dipeptidyl enoates as potent rhodesain inhibitors that display a dual mode of action [Communication] (Publications)
Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoa
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188... (Publications)
BACKGROUND: Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national he
Safety and immunogenicity of a candidate bioconjugate vaccine against <em>Shigella dysenteriae</em> type 1 administered to healthy adults: a single... (Publications)
BACKGROUND: Shigellae cause severe disease in endemic countries, especially in children. Several efficacy trials have been conducted with candidate vaccines against Shigellae, but the lack of protecti
A new nonpolar N-hydroxy imidazoline lead compound with improved activity in a murine model of late stage <em>Trypanosoma brucei brucei</em> infection... (Publications)
Treatment of late-stage sleeping sickness requires drugs that can cross the blood-brain barrier (BBB) to reach the parasites located in the brain. We report here the synthesis and evaluation of four n
Acute schistosomiasis: a risk underestimated by travelers and a diagnosis frequently missed by general practioners - a cluster analysis of 42... (Publications)
BACKGROUND: In 2011, a patient was admitted to our hospital with acute schistosomiasis after having returned from Madagascar and having bathed at the Lily waterfalls. On the basis of this patient's in