Transmission dynamics and economics of rabies control in dogs and humans in an African city (Publications)
at dogs. Potential cost-savings for the public health sector of interventions aimed at animal-host reservoirs should be assessed. Available deterministic models of rabies transmission between dogs were extended [...] effects of mass dog vaccination and the culling of a percentage of the dog population on human rabies incidence. A single parenteral dog rabies-mass vaccination campaign achieving a coverage of least 70% [...] week). The effective reproductive ratio (R(e)) at the onset of our...
A tradition and an epidemic: determinants of the campylobacteriosis winter peak in Switzerland (Publications)
median duration of illness of 7 days and 14 % were hospitalised. Meat fondues, mostly "Fondue chinoise", traditionally consumed during the festive season in Switzerland, are the major driver of the epidemic [...] and consumption of chicken meat may play an important role in disease transmission. Laboratory-confirmed patients are severely ill and hospitalisation rate is considerable. Public health measures such as [...] 1-6.4). Univariable analysis among meat fondue consumers revealed chicken as...
Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic... (Publications)
still of great public health relevance, and a severe impediment to agriculture in endemic areas. The pathogens possess certain unique metabolic features that can be exploited for the development of new drugs [...] vivo study showed that modest doses of 15 and 16 reduced parasitaemia of mice infected with T. b. rhodesiense (STIB900). These compounds represent a promising new class of potent and selective hits against [...] and therefore an attractive target for the design of safe drugs. In this...
Daily variation of heavy metal contamination and its potential sources along the major urban wastewater channel in Kampala, Uganda (Publications)
a better understanding of the short-term variation of these pollutants and industrial discharge practices is needed. The aim of this study is to assess the daily variation of heavy metals and physicochemical [...] has become a major concern to the environment and public health in many rapidly growing cities in low-income countries. Previous studies on heavy metals of urban wastewater systems have focused on long-term [...] at 16 locations and analyzed for lead (Pb), mercury (Hg), copper (Cu),...
Effects of radon and UV exposure on skin cancer mortality in Switzerland (Publications)
risk factors for skin cancer mortality. A better understanding of the role of the UV radiation and radon exposure is of high public health relevance. https://doi.org/10.1289/EHP825. [...] primary cause of death. Adjusted hazard ratios (HR) for MM at age 60 were 1.16 (95% CI: 1.04, 1.29) per radon and 1.11 (1.01, 1.23) per in UV dose. Radon effects decreased with age. Risk of MM death associated [...] adhere to the skin and potentially cause carcinogenic effects. OBJECTIVES: We investigated the...
Impact of the warm summer 2015 on emergency hospital admissions in Switzerland (Publications)
BACKGROUND: Only a few studies have examined the impact of a particular heat event on morbidity. The aim of this study was to evaluate the impact of the warm summer 2015 on emergency hospital admissions [...] summer 2015 ranks as the second hottest after 2003 in the history of temperature observation in Switzerland. METHODS: Daily counts of EHA for various disease categories during summer 2015 were analyzed [...] certain infectious diseases and diseases of the genitourinary system. CONCLUSIONS:...
Population genomics of <em>Mycobacterium leprae</em> reveals a new genotype in Madagascar and the Comoros (Publications)
settlement of Madagascar traces back to the beginning of the first millennium with the arrival of Austronesians from Southeast Asia, followed by migrations from Africa and the Middle East. Remains of these [...] considered a public health problem and monitored as part of a drug resistance surveillance program. Most M. leprae strains (97%) from Madagascar and Comoros belonged to a new genotype as part of branch 1, [...] are still present in Madagascar and other islands of the Indian Ocean. The...
Traditional milk transformation schemes in Côte d'Ivoire and their impact on the prevalence of <em>Streptococcus bovis</em> complex bacteria in dairy... (Publications)
human and animal diseases. Sii predominate in spontaneously fermented milk products with unknown public health effects. Sii/SBSEC prevalence data from West Africa in correlation with milk transformation practices [...] its importance in milk production and consumption and to link a wider Sudano-Sahelian pastoral zone of cross-border trade. We aimed to describe the cow milk value chain and determine Sii/SBSEC prevalence [...] by collection stage, fermented milk at producer and vendor levels...
Youth as agents of change in raising AMR awareness in the community in Dodoma region (Publications)
One of the strategic objectives of the AMR national action plan is to improve public awareness and understanding of AMR. Changing people's behaviour is not easy and the older a person is, the more they [...] content of the training included topics such as behaviour that fuels AMR, hand hygiene and sanitation, the impact of fake drugs and the One Health approach.In 2020, the project build the capacity of 160 students [...] Roll Back Antimicrobial resistance Initiative (RBA Initiative) has been...
Projections of excess mortality related to diurnal temperature range under climate change scenarios: a multi-country modelling study (Publications)
climatic changes, our findings could contribute to public health interventions aimed at reducing the impact of DTR on human health. FUNDING: Korea Ministry of Environment. [...] retrospective studies have reported on the increase of mortality risk due to higher diurnal temperature range (DTR). This study projects the effect of DTR on future mortality across 445 communities in 20 [...] countries and regions. METHODS: DTR-related mortality risk was estimated on the basis of the historical daily...