Unit | Malaria Gene Regulation
Function of Heterochromatin Protein 1
This project aims to deliver a detailed understanding of HP1 function in malaria parasites by conducting functional complementation assays and by identifying and characterising interacting partners and post-translational modifications of HP1.
Gametocyte Conversion and Differentiation
In this project we try to understand the molecular pathways and epigenetic control mechanisms congregating at the ap2-g locus to control the switch from asexual proliferation to sexual commitment and early differentiation of P. falciparum gametocytes.
In this project we investigate several regulatory proteins and DNA elements potentially implicated in the silencing and clonally variant expression of the var/PfEMP1 family. We hope such knowledge will help us to understand how P. falciparum controls antigenic variation, i.e. how it manages to express only a single var gene at a time and to switch expression between var gene loci.
Latest PublicationsAll Publications
Bertschi N.L et al. Malaria parasites possess a telomere repeat-binding protein that shares ancestry with transcription factor IIIA. Nat Microbiol. 2017;2:17033. DOI: 10.1038/nmicrobiol.2017.33
Josling G.A et al. A Plasmodium falciparum bromodomain protein regulates invasion gene expression. Cell Host Microbe. 2015;17(6):741-751. DOI: 10.1016/j.chom.2015.05.009
Filarsky M et al. The extended AT-hook is a novel RNA binding motif. RNA Biol. 2015;12(8):864-876. DOI: 10.1080/15476286.2015.1060394
Pelle K.G et al. Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection. Genome Med. 2015;7:19. DOI: 10.1186/s13073-015-0133-7
Brancucci N.M, Witmer K, Schmid C, Voss T.S. A var gene upstream element controls protein synthesis at the level of translation initiation in Plasmodium falciparum. PLoS One. 2014;9(6):e100183. DOI: 10.1371/journal.pone.0100183