Bresser M, Erhardt R.M, Shanaube K, Simwinga M, Mahlatsi P.A, Belus J, Schaap A, Amstutz A, Gachie T, Glass T.R, Kangololo B, Mota J, Floyd S, Katende B, Klinkenberg E, Ayles H, Reither K, Ruperez M. Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia. PLoS One. 2024;19(2):e0280105. DOI: 10.1371/journal.pone.0280105

2024
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Hiza H, Zwyer M, Hella J, Arbués A, Sasamalo M, Borrell S, Xu Z.M, Ross A, Brites D, Fellay J, Reither K, Gagneux S, Portevin D. Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania. Sci Rep. 2024;14(1):9287. DOI: 10.1038/s41598-024-60001-0

2024
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Tschan Y, Sasamalo M, Hiza H, Fellay J, Gagneux S, Reither K, Hella J, Portevin D. Diagnostic accuracy of a sequence-specific Mtb-DNA hybridization assay in urine: a case-control study including subclinical TB cases. Microbiol Spectr. 2024(in press). DOI: 10.1128/spectrum.00426-24

2024
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Vanobberghen F, Keter A.K, Jacobs B.K.M, Glass T.R, Lynen L, Law I, Murphy K, van Ginneken B, Ayakaka I, van Heerden A, Maama L, Reither K. Computer-aided detection thresholds for digital chest radiography interpretation in tuberculosis diagnostic algorithms. ERJ Open Res. 2024;10. DOI: 10.1183/23120541.00508-2023

2024
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Gils T, Kamele M, Madonsela T, Bosman S, Ngubane T, Joseph P, Reither K, Bresser M, Vlieghe E, Decroo T, Ayakaka I, Lynen L, Van Heerden A. Implementation of the advanced HIV disease care package with point-of-care CD4 testing during tuberculosis case finding: a mixed-methods evaluation. PLoS One. 2023;18(12):e0296197. DOI: 10.1371/journal.pone.0296197

2023
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Glaser N, Bosman S, Madonsela T, van Heerden A, Mashaete K, Katende B, Ayakaka I, Murphy K, Signorell A, Lynen L, Bremerich J, Reither K. Incidental radiological findings during clinical tuberculosis screening in Lesotho and South Africa: a case series. J Med Case Rep. 2023;17(1):365. DOI: 10.1186/s13256-023-04097-4

2023
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Katende B, Bresser M, Kamele M, Chere L, Tlahali M, Erhardt R.M, Muhairwe J, Ayakaka I, Glass T.R, Ruhwald M, van Ginneken B, Murphy K, de Vos M, Amstutz A, Mareka M, Mooko S.M, Reither K, González Fernández L. Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho. PLOS Glob Public Health. 2023;3(8):e0001488. DOI: 10.1371/journal.pgph.0001488

2023
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Keter A.K, Lynen L, Van Heerden A, Wong E, Reither K, Goetghebeur E, Jacobs B.K.M. Evaluation of tuberculosis diagnostic test accuracy using Bayesian latent class analysis in the presence of conditional dependence between the diagnostic tests used in a community-based tuberculosis screening study. PLoS One. 2023;18(3):e0282417. DOI: 10.1371/journal.pone.0282417

2023
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Klinkenberg E, Katende B, Ruperez M, Bresser M, Kangololo B, Bwalya J, Erhardt R.M, Schaap A, Kasese N, Gatchie T, Floyd S, Mota J, Ayles H, Shanaube K, Reither K. Creating access to SARS-CoV-2 screening and testing through community-based COVID-19 case-finding, observations from cross-sectional studies in Lesotho and Zambia. BMC Public Health. 2023;23:1414. DOI: 10.1186/s12889-023-16306-2

2023
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Labhardt N.D, González Fernández L, Katende B, Muhairwe J, Bresser M, Amstutz A, Glass T.R, Ruhwald M, Sacks J.A, Escadafal C, Mareka M, Mooko S.M, de Vos M, Reither K. Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho. PLoS One. 2023;18(3):e0278653. DOI: 10.1371/journal.pone.0278653

2023
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Loiseau C, Windels E.M, Gygli S.M, Jugheli L, Maghradze N, Brites D, Ross A, Goig G, Reinhard M, Borrell S, Trauner A, Dötsch A, Aspindzelashvili R, Denes R, Reither K, Beisel C, Tukvadze N, Avaliani Z, Stadler T, Gagneux S. The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot. Nat Commun. 2023;14:1988. DOI: 10.1038/s41467-023-37719-y

2023
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Murphy K, Muhairwe J, Schalekamp S, van Ginneken B, Ayakaka I, Mashaete K, Katende B, van Heerden A, Bosman S, Madonsela T, González Fernández L, Signorell A, Bresser M, Reither K, Glass T.R. COVID-19 screening in low resource settings using artificial intelligence for chest radiographs and point-of-care blood tests. Sci Rep. 2023;13:19692. DOI: 10.1038/s41598-023-46461-w

2023
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Ndege R, Ngome O, Vanobberghen F, Bani F, Temba Y, Wilson H, Hella J, Gingo W, Sasamalo M, Mnzava D, Kimera N, Hiza H, Wigayi J, Mapesi H, Kato I.B, Mhimbira F, Reither K, Battegay M, Paris D.H, Weisser M, Rohacek M. Ultrasononography in managing extrapulmonary tuberculosis: a randomized, controlled, parallel, superiority, open-label trial. Clin Infect Dis. 2023;76(6):1013-1021. DOI: 10.1093/cid/ciac871

2023
Journal Article
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Nooh F, Chernet A, Reither K, Okuma J, Brattig N.W, Utzinger J, Probst-Hensch N, Paris D.H, Dreyfus A. Prevalence of fever of unidentified aetiology in East African adolescents and adults: a systematic review and meta-analysis. Infect Dis Poverty. 2023;12:55. DOI: 10.1186/s40249-023-01105-z

2023
Journal Article
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Ntinginya N.E, Bakuli A, Mapamba D, Sabiiti W, Kibiki G, Minja L.T, Kuchaka D, Reither K, Phillips P.P.J, Boeree M.J, Gillespie S.H, Hoelscher M, Heinrich N. Tuberculosis molecular bacterial load assay reveals early delayed bacterial killing in patients with relapse. Clin Infect Dis. 2023;76(3):e990-e994. DOI: 10.1093/cid/ciac445

2023
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Simwinga M, Mahlatsi P.A, Molale M, Witola G, Mshanga I, Katende B, Amstutz A, Reither K, Shanaube K, Motlomelo M, Bond V, Belus J.M. Facilitators and barriers to COVID-19 testing in community and clinical settings: lessons learned from Lesotho and Zambia. PLOS Glob Public Health. 2023;3(10):e0002430. DOI: 10.1371/journal.pgph.0002430

2023
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Zwyer M, Rutaihwa L.K, Windels E, Hella J, Menardo F, Sasamalo M, Sommer G, Schmülling L, Borrell S, Reinhard M, Dötsch A, Hiza H, Stritt C, Sikalengo G, Fenner L, De Jong B.C, Kato-Maeda M, Jugheli L, Ernst J.D, Niemann S, Jeljeli L, Ballif M, Egger M, Rakotosamimanana N, Yeboah-Manu D, Asare P, Malla B, Dou H.Y, Zetola N, Wilkinson R.J, Cox H, Carter E.J, Gnokoro J, Yotebieng M, Gotuzzo E, Abimiku A, Avihingsanon A, Xu Z.M, Fellay J, Portevin D, Reither K, Stadler T, Gagneux S, Brites D. Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania. PLoS Pathog. 2023;19(4):e1010893. DOI: 10.1371/journal.ppat.1010893

2023
Journal Article
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Gils T, Lynen L, Muhairwe J, Mashaete K, Lejone T.I, Joseph P, Ngubane T, Keter A.K, Reither K, van Heerden A. Feasibility of implementing the advanced HIV disease care package as part of community-based HIV/TB activities: a mixed-methods study protocol. BMJ Open. 2022;12(2):e057291. DOI: 10.1136/bmjopen-2021-057291

2022
Journal Article
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Hiza H, Hella J, Arbués A, Sasamalo M, Misana V, Fellay J, Gagneux S, Reither K, Portevin D. CD38 expression by antigen-specific CD4 t cells is significantly restored 5 months after treatment initiation independently of sputum bacterial load at the time of tuberculosis diagnosis. Front Med. 2022;9:821776. DOI: 10.3389/fmed.2022.821776

2022
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Katende B, González Fernández L, Muhairwe J, Glass T.R, Ayakaka I, Labhardt N.D, Ruhwald M, de Vos M, Bresser M, Reither K. Diagnosis of SARS-CoV-2 infection from breath: a proof-of-concept study. IJID Reg. 2022;5:163-164. DOI: 10.1016/j.ijregi.2022.10.007

2022
Journal Article
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Tavaziva G, Harris M, Abidi S.K, Geric C, Breuninger M, Dheda K, Esmail A, Muyoyeta M, Reither K, Majidulla A, Khan A.J, Campbell J.R, David P.M, Denkinger C, Miller C, Nathavitharana R, Pai M, Benedetti A, Khan F.A. Chest X-ray analysis with deep learning-based software as a triage test for pulmonary tuberculosis: an individual patient data meta-analysis of diagnostic accuracy. Clin Infect Dis. 2022;74(8):1390–1400. DOI: 10.1093/cid/ciab639

2022
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Xu Z.M, Rüeger S, Zwyer M, Brites D, Hiza H, Reinhard M, Rutaihwa L, Borrell S, Isihaka F, Temba H, Maroa T, Naftari R, Hella J, Sasamalo M, Reither K, Portevin D, Gagneux S, Fellay J. Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations. PLoS Comput Biol. 2022;18(1):e1009628. DOI: 10.1371/journal.pcbi.1009628

2022
Journal Article
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Zoller T, Mfinanga E.H, Zumba T.B, Asilia P.J, Mutabazi E.M, Wimmersberger D, Mhimbira F, Haraka F, Reither K. Symptoms and functional limitations related to respiratory health and carbon monoxide poisoning in Tanzania: a cross sectional study. Environ Health. 2022;21:38. DOI: 10.1186/s12940-022-00847-x

2022
Journal Article
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Gygli S.M, Loiseau C, Jugheli L, Adamia N, Trauner A, Reinhard M, Ross A, Borrell S, Aspindzelashvili R, Maghradze N, Reither K, Beisel C, Tukvadze N, Avaliani Z, Gagneux S. Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis. Nat Med. 2021;27:1171–1177. DOI: 10.1038/s41591-021-01358-x

2021
Journal Item
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Gygli S.M, Loiseau C, Jugheli L, Adamia N, Trauner A, Reinhard M, Ross A, Borrell S, Aspindzelashvili R, Maghradze N, Reither K, Beisel C, Tukvadze N, Avaliani Z, Gagneux S. Publisher Correction: Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis. Nat Med. 2021;27(7):1308. DOI: 10.1038/s41591-021-01417-3

2021
Journal Item
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Haraka F, Kakolwa M, Schumacher S.G, Nathavitharana R.R, Denkinger C.M, Gagneux S, Reither K, Ross A. Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis (Review). Cochrane Database Syst Rev. 2021;2021(4):CD012972. DOI: 10.1002/14651858.CD012972.pub2

2021
Journal Article
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Hiza H, Hella J, Arbués A, Magani B, Sasamalo M, Gagneux S, Reither K, Portevin D. Case-control diagnostic accuracy study of a non-sputum CD38-based TAM-TB test from a single milliliter of blood. Sci Rep. 2021;11(1):13190. DOI: 10.1101/2021.03.10.21253246

2021
Journal Article
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Hodel N.C, Hamad A, Reither K, Kasella I.M, Abdulla S, Schoetzau A, Hatz C.F.R, Mayr M. Comparison of two different semiquantitative urinary dipstick tests with albumin-to-creatinine ratio for screening and classification of albuminuria according to KDIGO. A diagnostic test study. Diagnostics. 2021;11(1):81. DOI: 10.3390/diagnostics11010081

2021
Journal Article
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Minja L.T, Hella J, Mbwambo J, Nyandindi C, Omary U.S, Levira F, Mpagama S, Shimwela M, Okuma J, Gagneux S, Bruce R.D, Reither K. High burden of tuberculosis infection and disease among people receiving medication-assisted treatment for substance use disorder in Tanzania. PLoS One. 2021;16(4):e0250038. DOI: 10.1371/journal.pone.0250038

2021
Journal Article
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Ticlla M.R, Hella J, Hiza H, Sasamalo M, Mhimbira F, Rutaihwa L.K, Droz S, Schaller S, Reither K, Hilty M, Comas I, Beisel C, Schmid C.D, Fenner L, Gagneux S. The sputum microbiome in pulmonary tuberculosis and its association with disease manifestations: a cross-sectional study. Front Microbiol. 2021;12:633396. DOI: 10.3389/fmicb.2021.633396

2021
Journal Article
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Arpagaus A, Franzeck F.C, Sikalengo G, Ndege R, Mnzava D, Rohacek M, Hella J, Reither K, Battegay M, Glass T.R, Paris D.H, Bani F, Rajab O.N, Weisser M, Kiularco Study Group. Extrapulmonary tuberculosis in HIV-infected patients in rural Tanzania: the prospective Kilombero and Ulanga antiretroviral cohort. PLoS One. 2020;15(3):e0229875. DOI: 10.1371/journal.pone.0229875

2020
Journal Article
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Haraka F, Schumacher S.G, Ross A, Mantsoki A, Gagneux S, Reither K, Denkinger C.M. Effect of history of tuberculosis on specificity of Xpert MTB/RIF. Eur Respir J. 2020;56(3):2000343. DOI: 10.1183/13993003.00343-2020

2020
Journal Article
PubMed

Hodel N.C, Hamad A, Reither K, Mwangoka G, Kasella I, Praehauser C, Abdulla S, Hatz C.F.R, Mayr M. Assessment of diabetes and prediabetes prevalence and predictors by HbA1c in a population from sub-Saharan Africa with a high proportion of anemia: a prospective cross-sectional study. BMJ Open Diabetes Res Care. 2020;8(1):e000939. DOI: 10.1136/bmjdrc-2019-000939

2020
Journal Article
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Ndege R, Ngome O, Bani F, Temba Y, Wilson H, Vanobberghen F, Hella J, Gingo W, Sasamalo M, Mnzava D, Kimera N, Hiza H, Wigayi J, Mapesi H, Kato I.B, Mhimbira F, Reither K, Battegay M, Paris D.H, Weisser M, Rohacek M. Ultrasound in managing extrapulmonary tuberculosis: a randomized controlled two-center study. BMC Infect Dis. 2020;20:349. DOI: 10.1186/s12879-020-05073-9

2020
Journal Article
PubMed

Abidi S.K, Harris M, Muyoyeta M, Dheda K, Esmail A, Reither K, Breuninger M, Qi A, Denkinger C, Korobitsyn A, Pai M, Benedetti A, Khan F.A. An individual patient data meta-analysis to estimate the diagnostic accuracy of a machine learning-based software for analyzing chest x-rays of persons with symptoms of pulmonary tuberculosis: preliminary findings. Am J Respir Crit Care Med, 2019;199:A5167. DOI: 10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A5167

2019
Conference Paper

Amelio P, Portevin D, Hella J, Reither K, Kamwela L, Lweno O, Tumbo A, Geoffrey L, Ohmiti K, Ding S, Pantaleo G, Daubenberger C, Perreau M. HIV infection functionally impairs Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses. J Virol. 2019;93(5):e01728-18. DOI: 10.1128/JVI.01728-18

2019
Journal Article
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Maghradze N, Jugheli L, Borrell S, Tukvadze N, Aspindzelashvili R, Avaliani Z, Reither K, Gagneux S. Classifying recurrent Mycobacterium tuberculosis cases in Georgia using MIRU-VNTR typing. PLoS One. 2019;14(10):e0223610. DOI: 10.1371/journal.pone.0223610

2019
Journal Article
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Mhalu G, Hella J, Mhimbira F, Said K, Mosabi T, Mlacha Y.P, Schindler C, Gagneux S, Reither K, de Hoogh K, Weiss M.G, Zemp E, Fenner L. Pathways and associated costs of care in patients with confirmed and presumptive tuberculosis in Tanzania: a cross-sectional study. BMJ Open. 2019;9(4):e025079. DOI: 10.1136/bmjopen-2018-025079

2019
Journal Article
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Mhalu G, Weiss M.G, Hella J, Mhimbira F, Mahongo E, Schindler C, Reither K, Fenner L, Zemp E, Merten S. Explaining patient delay in healthcare seeking and loss to diagnostic follow-up among patients with presumptive tuberculosis in Tanzania: a mixed-methods study. BMC Health Serv Res. 2019;19:217. DOI: 10.1186/s12913-019-4030-4

2019
Journal Article
PubMed

Mhimbira F, Hiza H, Mbuba E, Hella J, Kamwela L, Sasamalo M, Ticlla M, Said K, Mhalu G, Chiryamkubi M, Schindler C, Reither K, Gagneux S, Fenner L. Prevalence and clinical significance of respiratory viruses and bacteria detected in tuberculosis patients compared to household contact controls in Tanzania: a cohort study. Clin Microbiol Infect. 2019;25(1):107 e1-107 e7. DOI: 10.1016/j.cmi.2018.03.019

2019
Journal Article
PubMed