Publications

Ajayi D.T, Orherhe O.M, Pillai G.C, Mouksassi S, Steffens B, Bräm D, Sprecher V, Hofmann D, Buettcher M, Coulibaly J.T, Ali S.M, Keiser J, Pfister M. Pharmacometric analysis to describe pharmacokinetics and exposure-efficacy response of ivermectin in adolescents infected with Trichuris trichiura. J Clin Pharmacol. 2025;65(4):433-440. DOI: 10.1002/jcph.6158

Dupouy B, Karpstein T, Häberli C, Cal M, Rottmann M, Mäser P, Keiser J, Elhabiri M, Davioud-Charvet E. Synthesis of 1,2,3-triazole-methyl-menadione derivatives: evaluation of electrochemical and antiparasitic properties against two blood-dwelling parasites. ChemMedChem. 2025;20(6):e202400731. DOI: 10.1002/cmdc.202400731

Dziwornu G.A, Attram H.D, Häberli C, Masike K, Njoroge M, Keiser J. Benzimidazole analogues active against adult Schistosoma mansoni: SAR analyses, in vivo efficacy in mice, and preliminary mechanistic studies as potential inhibitors of hemozoin formation. Eur J Med Chem. 2025;284:117186. DOI: 10.1016/j.ejmech.2024.117186

Lo N.C, Addiss D.G, Buonfrate D, Amor A, Anegagrie M, Bisoffi Z, Bradbury R.S, Keiser J, Kepha S, Khieu V, Krolewiecki A, Mbonigaba J.B, Muñoz J, Mutapi F, Novela V, Vaz Nery S, Coffeng L.E, de Vlas S.J, Bartoszko J, Moja L, Mupfasoni D, Montresor A. Review of the WHO guideline on preventive chemotherapy for public health control of strongyloidiasis. Lancet Infect Dis. 2025;25(3):e146-e152. DOI: 10.1016/s1473-3099(24)00595-4

Lotz C.N, Mrimi E.C, Schneeberger P.H.H, Ali S.M, Hattendorf J, Keiser J. Performance of real-time polymerase chain reaction and Kato-Katz for diagnosing soil-transmitted helminth infections and evaluating treatment efficacy of emodepside in randomized controlled trials. PLoS Negl Trop Dis. 2025;19(2):e0012872. DOI: 10.1371/journal.pntd.0012872

Lotz C.N, Schneeberger P.H.H, Concu M, Ali S.M, Mrimi E.C, Keiser J. Implementation of real-time PCR assays for diagnosing intestinal protozoa infections. Parasitol Res. 2025;124(4):40. DOI: 10.1007/s00436-025-08483-3

Malan D, Van Niekerk S, Häberli C, Keiser J, Van der Kooy F. In vitro antischistosomal activity of Artemisia species. Acta Trop. 2025;262:107535. DOI: 10.1016/j.actatropica.2025.107535

Ueberall M.E, Berchthold M, Häberli C, Lindemann S, Spangenberg T, Keiser J, Grevelding C.G. Merck Open Global Health Library in vitro screening against Schistosoma mansoni identified two new substances with antischistosomal activities for further development. Parasit Vectors. 2025;18:40. DOI: 10.1186/s13071-024-06648-0

Venkatesan A, Chen R, Bär M, Schneeberger P.H.H, Reimer B, Hürlimann E, Coulibaly J.T, Ali S.M, Sayasone S, Soghigian J, Keiser J, Gilleard J.S. Trichuriasis in human patients from Côte d'Ivoire caused by novel Trichuris incognita species with low sensitivity to albendazole/ivermectin combination treatment. Emerg Infect Dis. 2025;31(1):104-114. DOI: 10.3201/eid3101.240995

Brooker S.J, Keiser J, Bundy D.A.P. Soil-transmitted helminths (geohelminths). In: Farrar J,Hotez P.J,Junghanss T,Kang G,Lalloo D,White N.J,Garcia P.J, eds. Manson's Tropical Diseases, 772-796. Amsterdam: Elsevier, 2024. DOI: 10.1016/B978-0-7020-7959-7.00060-9

Cesar-Rodo E, Dupouy B, Häberli C, Strub J.M, Williams D.L, Mäser P, Rottmann M, Keiser J, Lanfranchi D.A, Davioud-Charvet E. Regioselective synthesis of potential non-quinonoid prodrugs of plasmodione: antiparasitic properties against two hemoglobin-feeding parasites and drug metabolism studies. Molecules. 2024;29(22):5268. DOI: 10.3390/molecules29225268

Davie T, Serrat X, Imhof L, Snider J, Štagljar I, Keiser J, Hirano H, Watanabe N, Osada H, Fraser A.G. Identification of a family of species-selective complex I inhibitors as potential anthelmintics. Nat Commun. 2024;15:3367. DOI: 10.1038/s41467-024-47331-3

Dommann J, Keiser J, Garneau J, Gandelin A, Casanova C, Keller P.M, Sayasone S, Vonaesch P, Schneeberger P.H.H. Exposure of gut bacterial isolates to the anthelminthic drugs, ivermectin and moxidectin, leads to antibiotic-like phenotypes of growth inhibition and adaptation. Commun Biol. 2024;7:1566. DOI: 10.1038/s42003-024-07135-z

Dommann J, Kerbl-Knapp J, Albertos Torres D, Egli A, Keiser J, Schneeberger P.H.H. A novel barcoded nanopore sequencing workflow of high-quality, full-length bacterial 16S amplicons for taxonomic annotation of bacterial isolates and complex microbial communities. mSystems. 2024;9(10):e0085924. DOI: 10.1128/msystems.00859-24

Emerson P.M, Evans D, Freeman M.C, Hanson C, Kalua K, Keiser J, Krolewiecki A, Leonard L, Levecke B, Matendechero S, Means A.R, Montresor A, Mupfasoni D, Pullan R.L, Rotondo L.A, Stephens M, Sullivan K.M, Walson J.L, Williams T, Utzinger J. Need for a paradigm shift in soil-transmitted helminthiasis control: targeting the right people, in the right place, and with the right drug(s). PLoS Negl Trop Dis. 2024;18(10):e0012521. DOI: 10.1371/journal.pntd.0012521

Fuchs N, Zimmermann R.A, Schwickert M, Gunkel A, Zimmer C, Meta M, Schwickert K, Keiser J, Häberli C, Kiefer W, Schirmeister T. Dual strategy to design new agents targeting Schistosoma mansoni: advancing phenotypic and SmCB1 inhibitors for improved efficacy. ACS Infect Dis. 2024;10(5):1664-1678. DOI: 10.1021/acsinfecdis.4c00020

González Cabrera D, Keiser J, Spangenberg T. Analysis of the physicochemical properties of anti-schistosomal compounds to identify next-generation leads. ACS Med Chem Lett. 2024;15(5):626-630. DOI: 10.1021/acsmedchemlett.4c00026

Gordon C.A, Utzinger J, Muhi S, Becker S.L, Keiser J, Khieu V, Gray D.J. Strongyloidiasis. Nat Rev Dis Primers. 2024;10:6. DOI: 10.1038/s41572-023-00490-x

Grolimund C.M, Utzinger J, Coulibaly J.T, Sayasone S, Ali S.M, Keiser J, Vounatsou P. Modeling transmission mechanism to infer treatment efficacy of different drugs and combination therapy against Trichuris trichiura. Sci Rep. 2024;14:23543. DOI: 10.1038/s41598-024-73164-7

Keiser J, Bouchery T. A step forward in the journey towards hookworm vaccines. Lancet Infect Dis. 2024;24(7):673-674. DOI: 10.1016/s1473-3099(24)00145-2

Kuevi D.N.O, Keiser J, Häberli C, Owusu-Senyah A.K, Ahiabu M.K. In vitro antischistosomal activity of Bridelia ferruginea, Clausena anisata, Khaya senegalensis, and Vernonia amygdalina. J Trop Med. 2024;2024(1):8074291. DOI: 10.1155/2024/8074291

Leas D.A, Keiser J, Charman S.A, Shackleford D.M, Jones J.O, Campbell M, Chen G, Katneni K, Patil R, Hu M, Pham T, Häberli C, Schulze T.T, Neville A.J, Wang X, Dong Y, Davis P.H, Vennerstrom J.L. Single-dose drug development candidate for schistosomiasis. ACS Infect Dis. 2024;10(11):3963-3972. DOI: 10.1021/acsinfecdis.4c00677

Lotz C.N, Krollenbrock A, Imhof L, Riscoe M, Keiser J. Robenidine derivatives as potential antischistosomal drug candidates. Int J Parasitol Drugs Drug Resist. 2024;25:100546. DOI: 10.1016/j.ijpddr.2024.100546

Palmeirim M.S, Hürlimann E, Beinamaryo P, Kyarisiima H, Nabatte B, Hattendorf J, Steinmann P, Keiser J. Efficacy and safety of albendazole alone versus albendazole in combination with ivermectin for the treatment of Trichuris trichiura infections: an open-label, randomized controlled superiority trial in south-western Uganda. PLoS Negl Trop Dis. 2024;18(11):e0012687. DOI: 10.1371/journal.pntd.0012687

Pillay-Fuentes Lorente V, Nwogu-Attah J.N, Steffens B, Bräm D, Sprecher V, Hofmann D, Buettcher M, Pillai G, Mouksassi S, Coulibaly J, Pfister M, Keiser J. Understanding drug exposure and Trichuris trichiura cure rates: a pharmacometric approach for albendazole-ivermectin co-medication in Tanzania and Côte d'Ivoire. Drugs R D. 2024;24(2):331-340. DOI: 10.1007/s40268-024-00476-4

Qian M.B, Keiser J, Utzinger J, Zhou X.N. Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control. Clin Microbiol Rev. 2024;37(1):e0000923. DOI: 10.1128/cmr.00009-23

Ren R, Leas D.A, Häberli C, Cal M, Chen G, Katneni K, Dong Y, Kaiser M, Keiser J, Charman S.A, Vennerstrom J.L. Medium-ring keto bislactams with antischistosomal activity. J Med Chem. 2024;67(20):18235-18246. DOI: 10.1021/acs.jmedchem.4c01532

Shanley H.T, Taki A.C, Nguyen N, Wang T, Byrne J.J, Ang C.S, Leeming M.G, Nie S, Williamson N, Zheng Y, Young N.D, Korhonen P.K, Hofmann A, Chang B.C.H, Wells T.N.C, Häberli C, Keiser J, Jabbar A, Sleebs B.E, Gasser R.B. Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity. Int J Parasitol Drugs Drug Resist. 2024;24:100522. DOI: 10.1016/j.ijpddr.2024.100522

Sprecher V.P, Hofmann D, Savathdy V, Xayavong P, Norkhankhame C, Huy R, Khieu V, Sayasone S, Hattendorf J, Keiser J. Efficacy and safety of moxidectin compared with ivermectin against Strongyloides stercoralis infection in adults in Laos and Cambodia: a randomised, double-blind, non-inferiority, phase 2b/3 trial. Lancet Infect Dis. 2024;24(2):196-205. DOI: 10.1016/s1473-3099(23)00507-8

Stettler M, Lotz C, Probst A, Marreros N, Lundström-Stadelmann B, Frey C.F, Keiser J, Hofer A, Hoby S. Safety and pharmacokinetics of praziquantel in European pond turtles (Emys orbicularis). J Zoo Wildl Med. 2024;54(4):728-737. DOI: 10.1638/2023-0031

Taylor L, Ahmada A.A, Ali M.S, Ali S.M, Hattendorf J, Mohammed I.S, Keiser J. Efficacy and safety of emodepside compared with albendazole in adolescents and adults with hookworm infection in Pemba Island, Tanzania: a double-blind, superiority, phase 2b, randomised controlled trial. Lancet. 2024;404(10453):683-691. DOI: 10.1016/s0140-6736(24)01403-x

Vaillant M.T, Philippy F, Neven A, Barré J, Bulaev D, Olliaro P.L, Utzinger J, Keiser J, Garba A.T. Diagnostic tests for human Schistosoma mansoni and Schistosoma haematobium infection: a systematic review and meta-analysis. Lancet Microbe. 2024;5:e366-e378. DOI: 10.1016/s2666-5247(23)00377-4

van Beek A.E, Jeanguenat H, Häberli C, Pouw R.B, Lamers C, Pál G, Gál P, Schmidt C.Q, Ricklin D, Keiser J. Praziquantel and factor H recruitment differentially affect the susceptibility of Schistosoma mansoni to complement-mediated damage. Front Immunol. 2024;15:1474358. DOI: 10.3389/fimmu.2024.1474358

Welsche S, Schneeberger P.H.H, Hattendorf J, Sayasone S, Hürlimann E, Keiser J. Egg excretion patterns of soil-transmitted helminth infections in humans following albendazole-ivermectin and albendazole treatment. PLoS Negl Trop Dis. 2024;18(3):e0012073. DOI: 10.1371/journal.pntd.0012073

Biendl S, Häberli C, Chen G, Wang W, Zhong L, Saunders J, Pham T, Wang X, Wu J, Charman S.A, Vennerstrom J.L, Keiser J. In vitro and in vivo antischistosomal activity profiling and pharmacokinetics of ozonide carboxylic acids. ACS Infect Dis. 2023;9(3):643-652. DOI: 10.1021/acsinfecdis.2c00581

Cappuccino C, Spoletti E, Renni F, Muntoni E, Keiser J, Voinovich D, Perissutti B, Lusi M. Co-crystalline solid solution affords a high-soluble and fast-absorbing form of praziquantel. Mol Pharm. 2023;20(4):2009-2016. DOI: 10.1021/acs.molpharmaceut.2c00984

Coffeng L.E, Vlaminck J, Cools P, Denwood M, Albonico M, Ame S.M, Ayana M, Dana D, Cringoli G, de Vlas S.J, Fenwick A, French M, Kazienga A, Keiser J, Knopp S, Leta G, Matoso L.F, Maurelli M.P, Montresor A, Mirams G, Mekonnen Z, Corrêa-Oliveira R, Pinto S.A, Rinaldi L, Sayasone S, Steinmann P, Thomas E, Vercruysse J, Levecke B. A general framework to support cost-efficient fecal egg count methods and study design choices for large-scale STH deworming programs-monitoring of therapeutic drug efficacy as a case study. PLoS Negl Trop Dis. 2023;17(5):e0011071. DOI: 10.1371/journal.pntd.0011071

Coulibaly J.T, Silue K.D, Armstrong M, Díaz de León Derby M, D'Ambrosio M.V, Fletcher D.A, Keiser J, Fisher K, Andrews J.R, Bogoch I.I. High sensitivity of mobile phone microscopy screening for Schistosoma haematobium in Azaguié, Côte d'Ivoire. Am J Trop Med Hyg. 2023;108(1):41-43. DOI: 10.4269/ajtmh.22-0527

D'Abbrunzo I, Bianco E, Gigli L, Demitri N, Birolo R, Chierotti M.R, Škorić I, Keiser J, Häberli C, Voinovich D, Hasa D, Perissutti B. Praziquantel meets Niclosamide: a dual-drug antiparasitic cocrystal. Int J Pharm. 2023;644:123315. DOI: 10.1016/j.ijpharm.2023.123315

Easland E, Biendl S, Keiser J. Development of a hookworm egg hatching assay to determine the ovicidal effects of anthelminthics. Parasit Vectors. 2023;16:157. DOI: 10.1186/s13071-023-05771-8

Friedrich L, Park S.K, Ballard P, Ho Baeurle T.H, Maillard D, Bödding M, Keiser J, Marchant J.S, Spangenberg T. Metabolism of (R)-praziquantel versus the activation of a Parasite Transient Receptor Potential Melastatin ion channel. ChemMedChem. 2023;18(18):e202300140. DOI: 10.1002/cmdc.202300140

Hürlimann E, Hofmann D, Keiser J. Ivermectin and moxidectin against soil-transmitted helminth infections. Trends Parasitol. 2023;39(4):272-284. DOI: 10.1016/j.pt.2023.01.009

Kasago F.M, Häberli C, Keiser J, Masamba W. Design, synthesis and evaluation of praziquantel analogues and new molecular hybrids as potential antimalarial and anti-schistosomal agents. Molecules. 2023;28(13):5184. DOI: 10.3390/molecules28135184

Keiser J. Present drugs and future perspectives in treating soil-transmitted helminthiasis. Front Trop Dis. 2023;4:1282725. DOI: 10.3389/fitd.2023.1282725

Mäser P, Bernhard S, Brun R, Burri C, Gagneux S, Hetzel M.W, Kaiser M, Lengeler C, Pluschke G, Reus E, Rottmann M, Utzinger J, Warryn L, Wittlin S, Keiser J. Key contributions by the Swiss Tropical and Public Health Institute towards new and better drugs for tropical diseases. Chimia (Aarau). 2023;77(9):593-606. DOI: 10.2533/chimia.2023.593

Meier L, Antillón M, Burri C, Chitnis N, Endriss Y, Keiser J, Moore S, Müller P, Penny M, Voss T.S, Mäser P, Utzinger J. Repurposing know-how for drug development: case studies from the Swiss Tropical and Public Health Institute. Chimia (Aarau). 2023;77(9):582-592. DOI: 10.2533/chimia.2023.582

Mrimi E.C, Palmeirim M.S, Minja E.G, Long K.Z, Keiser J. Correlation of cytokines with parasitic infections, undernutrition and micronutrient deficiency among schoolchildren in rural Tanzania: a cross-sectional study. Nutrients. 2023;15(8):1916. DOI: 10.3390/nu15081916

Mrimi E.C, Welsche S, Ali S.M, Hattendorf J, Keiser J. Emodepside for Trichuris trichiura and hookworm infection. N Engl J Med. 2023;388(20):1863-1875. DOI: 10.1056/NEJMoa2212825

Muya K, Kalonji M, Ilunga N.W, Maseho M, Kitambala M, Kalonda M, Ndoumba K, Byanga K, Wright C.W, Häberli C, Keiser J, Simbi L. Evaluation of 43 species of Congolese medicinal plants used traditionally for the treatment of schistosomiasis leading to the isolation of an anti-schistosomal phaeophytin from Pseudolachnostylis maprouneifolia Pax. J Ethnopharmacol. 2023;315:116688. DOI: 10.1016/j.jep.2023.116688

Noce B, Di Bello E, Zwergel C, Fioravanti R, Valente S, Rotili D, Masotti A, Ansari M.S.Z, Trisciuoglio D, Chakrabarti A, Romier C, Robaa D, Sippl W, Jung M, Häberli C, Keiser J, Mai A. Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages. ChemMedChem. 2023;18(3):e202200510. DOI: 10.1002/cmdc.202200510

Radulov P.S, Yaremenko I.A, Keiser J, Terent'ev A.O. Bridged 1,2,4-trioxolanes: SnCl4-catalyzed synthesis and an in vitro study against S. mansoni. Molecules. 2023;28(13). DOI: 10.3390/molecules28134913

Schärer A, Biendl S, Keiser J. Trichuris muris egg-hatching assay for anthelminthic drug discovery and characterization. Int J Parasitol Drugs Drug Resist. 2023;23:63-70. DOI: 10.1016/j.ijpddr.2023.10.001

Specht S, Keiser J. Helminth infections: enabling the World Health Organization road map. Int J Parasitol. 2023;53(8):411-414. DOI: 10.1016/j.ijpara.2022.10.006

Sprecher V.P, Coulibaly J.T, Hürlimann E, Hattendorf J, Keiser J. Efficacy and safety of moxidectin-albendazole and ivermectin-albendazole combination therapy compared to albendazole monotherapy in adolescents and adults infected with Trichuris trichiura: a randomized controlled superiority trial. Clin Infect Dis. 2023;77(9):1294-1302. DOI: 10.1093/cid/ciad387

Welsche S, Mrimi E.C, Hattendorf J, Hürlimann E, Ali S.M, Keiser J. Efficacy and safety of moxidectin and albendazole compared with ivermectin and albendazole coadministration in adolescents infected with Trichuris trichiura in Tanzania: an open-label, non-inferiority, randomised, controlled, phase 2/3 trial. Lancet Infect Dis. 2023;23(3):331-340. DOI: 10.1016/S1473-3099(22)00589-8

Angeli A, Ferraroni M, Carta F, Häberli C, Keiser J, Costantino G, Supuran C.T. Development of praziquantel sulphonamide derivatives as antischistosomal drugs. J Enzyme Inhib Med Chem. 2022;37(1):1479-1494. DOI: 10.1080/14756366.2022.2078970

Biendl S, Häberli C, Keiser J. Discovery of novel antischistosomal scaffolds from the open access Pandemic Response Box. Expert Rev Anti Infect Ther. 2022;20(4):621-629. DOI: 10.1080/14787210.2022.1990042

Cantara A, Luo Y, Dobrovolna M, Bohalova N, Fojta M, Verga D, Guittat L, Cucchiarini A, Savrimoutou S, Häberli C, Guillon J, Keiser J, Brazda V, Mergny J.L. G-quadruplexes in helminth parasites. Nucleic Acids Res. 2022;50(5):2719-2735. DOI: 10.1093/nar/gkac129

Coulibaly J.T, Hürlimann E, Patel C, Silué D.K, Avenié D.J, Kouamé N.A, Silué U.M, Keiser J. Optimizing implementation of preventive chemotherapy against soil-transmitted helminthiasis and intestinal schistosomiasis using high-resolution data: field-based experiences from Côte d'Ivoire. Diseases. 2022;10(4):66. DOI: 10.3390/diseases10040066

Di Bello E, Noce B, Fioravanti R, Zwergel C, Valente S, Rotili D, Fianco G, Trisciuoglio D, Mourão M.M, Sales P. Jr, Lamotte S, Prina E, Späth G.F, Häberli C, Keiser J, Mai A. Effects of structurally different HDAC inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni. ACS Infect Dis. 2022;8(7):1356-1366. DOI: 10.1021/acsinfecdis.2c00232

Dube M, Llanes D, Saoud M, Rennert R, Imming P, Häberli C, Keiser J, Arnold N. Albatrellus confluens (Alb. & Schwein.) Kotl. & Pouz.: natural fungal compounds and synthetic derivatives with in vitro anthelmintic activities and antiproliferative effects against two human cancer cell lines. Molecules. 2022;27(9):2950. DOI: 10.3390/molecules27092950

Dube M, Raphane B, Sethebe B, Seputhe N, Tiroyakgosi T, Imming P, Häberli C, Keiser J, Arnold N, Andrae-Marobela K. Medicinal plant preparations administered by Botswana traditional health practitioners for treatment of worm infections show anthelmintic activities. Plants (Basel). 2022;11(21):2945. DOI: 10.3390/plants11212945

Falcoz C, Guzy S, Kovač J, Meister I, Coulibaly J, Sayasone S, Wesche D, Lin Y.W, Keiser J. R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini. J Pharmacokinet Pharmacodyn. 2022;49(3):293-310. DOI: 10.1007/s10928-021-09791-8

Falcoz C, Guzy S, Kovac J, Meister I, Coulibaly J, Sayasone S, Wesche D, Lin Y.W, Keiser J. Correction to: R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini. J Pharmacokinet Pharmacodyn. 2022;49(3):395. DOI: 10.1007/s10928-022-09807-x

Grolimund C.M, Bärenbold O, Utzinger J, Keiser J, Vounatsou P. Modeling the effect of different drugs and treatment regimen for hookworm on cure and egg reduction rates taking into account diagnostic error. PLoS Negl Trop Dis. 2022;16(10):e0010810. DOI: 10.1371/journal.pntd.0010810

Hamway Y, Zimmermann K, Blommers M.J.J, Sousa M, Häberli C, Kulkarni S, Skalicky S, Hackl M, Götte M, Keiser J, da Costa C.P, Spangenberg T, Azzaoui K. Modulation of host-parasite interactions with small molecules targeting Schistosoma mansoni microRNAs. ACS Infect Dis. 2022;8:2028−2034. DOI: 10.1021/acsinfecdis.2c00360

Harrington S, Knox J.J, Burns A.R, Choo K.L, Au A, Kitner M, Häberli C, Pyche J, D'Amata C, Kim Y.H, Volpatti J.R, Guiliani M, Snider J, Wong V, Palmeira B.M, Redman E.M, Vaidya A.S, Gilleard J.S, Stagljar I, Cutler S.R, Kulke D, Dowling J.J, Yip C.M, Keiser J, Zasada I, Lautens M, Roy P.J. Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release. Commun Biol. 2022;5:865. DOI: 10.1038/s42003-022-03819-6

Hassan M.M, Sedighi A, Olaoye O.O, Häberli C, Merz A, Ramos-Morales E, de Araujo E.D, Romier C, Jung M, Keiser J, Gunning P.T. Phenotypic screening of histone deacetylase (HDAC) inhibitors against Schistosoma mansoni. ChemMedChem. 2022:e202100622. DOI: 10.1002/cmdc.202100622

Herath H.M.P.D, Taki A.C, Rostami A, Jabbar A, Keiser J, Geary T.G, Gasser R.B. Whole-organism phenotypic screening methods used in early-phase anthelmintic drug discovery. Biotechnol Adv. 2022;57:107937. DOI: 10.1016/j.biotechadv.2022.107937

Hofmann D, Brussee J.M, Schulz J.D, Coulibaly J.T, Pfister M, Keiser J. Pharmacokinetic modelling and simulation to optimize albendazole dosing in hookworm- or Trichuris trichiura-infected infants to adults. J Antimicrob Chemother. 2022;77(4):1082-1093. DOI: 10.1093/jac/dkac020

Hofmann D, Smit C, Sayasone S, Pfister M, Keiser J. Optimizing moxidectin dosing for Strongyloides stercoralis infections: insights from pharmacometric modeling. Clin Transl Sci. 2022;15(3):700-708. DOI: 10.1111/cts.13189

Hürlimann E, Keller L, Patel C, Welsche S, Hattendorf J, Ali S.M, Ame S.M, Sayasone S, Coulibaly J.T, Keiser J. Efficacy and safety of co-administered ivermectin and albendazole in school-aged children and adults infected with Trichuris trichiura in Côte d'Ivoire, Laos, and Pemba Island, Tanzania: a double-blind, parallel-group, phase 3, randomised control. Lancet Infect Dis. 2022;22(1):123-135. DOI: 10.1016/S1473-3099(21)00421-7

Kersting L, Kuhn L, Anokhin M, Schuster F, Häberli C, Sambyal S, Kumar H.M.S, Keiser J, Alabugin I, Tsogoeva S.B. Visible-light-driven metal-free C-H functionalization: access to new bioactive tetrahydroisoquinoline-butenolide hybrids via domino amine oxidation/vinylogous Mannich reaction. ChemPhotoChem. 2022;6(8):e202200109. DOI: 10.1002/cptc.202200109

Mrimi E.C, Palmeirim M.S, Minja E.G, Long K.Z, Keiser J. Malnutrition, anemia, micronutrient deficiency and parasitic infections among schoolchildren in rural Tanzania. PLoS Negl Trop Dis. 2022;16(3):e0010261. DOI: 10.1371/journal.pntd.0010261

Olliaro P.L, Vaillant M.T, Diawara A, Speich B, Albonico M, Utzinger J, Keiser J. Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment. PLoS Negl Trop Dis. 2022;16(8):e0010593. DOI: 10.1371/journal.pntd.0010593

Probst A, Biendl S, Keiser J. Improving translational power in antischistosomal drug discovery. Adv Parasitol. 2022;117:47-73. DOI: 10.1016/bs.apar.2022.05.002

Probst A, Hofmann D, Fedorova O.S, Mazeina S.V, Sokolova T.S, Golovach E, Keiser J. Pharmacokinetics of ascending doses of praziquantel in adults infected with Opisthorchis felineus in Western Siberia, Russian Federation. Antimicrob Agents Chemother. 2022;66(10):e00526-22. DOI: 10.1128/aac.00526-22

Qian M.B, Patel C, Palmeirim M.S, Wang X, Schindler C, Utzinger J, Zhou X.N, Keiser J. Efficacy of drugs against clonorchiasis and opisthorchiasis: a systematic review and network meta-analysis. Lancet Microbe. 2022;3(8):e616-e624. DOI: 10.1016/S2666-5247(22)00026-X

Ravaynia P.S, Biendl S, Grassi F, Keiser J, Hierlemann A, Modena M.M. Real-time and automated monitoring of antischistosomal drug activity profiles for screening of compound libraries. iScience. 2022;25(4):104087. DOI: 10.1016/j.isci.2022.104087

Ren R, Wang X, Leas D.A, Häberli C, Cal M, Dong Y, Kaiser M, Keiser J, Vennerstrom J.L. Antischistosomal tetrahydro-γ-carboline sulfonamides. Bioorg Med Chem Lett. 2022;59:128546. DOI: 10.1016/j.bmcl.2022.128546

Schneeberger P.H.H, Gueuning M, Welsche S, Hürlimann E, Dommann J, Häberli C, Frey J.E, Sayasone S, Keiser J. Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases. Nat Commun. 2022;13:1063. DOI: 10.1038/s41467-022-28658-1

Smit C, Hofmann D, Sayasone S, Keiser J, Pfister M. Characterization of the population pharmacokinetics of moxidectin in adults infected with Strongyloides stercoralis: support for a fixed-dose treatment regimen. Clin Pharmacokinet. 2022;61:123-132. DOI: 10.1007/s40262-021-01048-4

Taki A.C, Wang T, Nguyen N.N, Ang C.S, Leeming M.G, Nie S, Byrne J.J, Young N.D, Zheng Y, Ma G, Korhonen P.K, Koehler A.V, Williamson N.A, Hofmann A, Chang B.C.H, Häberli C, Keiser J, Jabbar A, Sleebs B.E, Gasser R.B. Thermal proteome profiling reveals Haemonchus orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868. Front Pharmacol. 2022;13:1014804. DOI: 10.3389/fphar.2022.1014804

Taljaard L, Probst A, Tornow R, Keiser J, Haynes R.K, van der Kooy F. In vitro antischistosomal activity of Artemisia annua and Artemisia afra extracts. Phytomed Plus. 2022;2(3):100279. DOI: 10.1016/j.phyplu.2022.100279

Valderas-García E, Häberli C, Álvarez-Bardón M, Escala N, Castilla-Gómez de Agüero V, de la Vega J, Del Olmo E, Balaña-Fouce R, Keiser J, Martínez-Valladares M. Benzimidazole and aminoalcohol derivatives show in vitro anthelmintic activity against Trichuris muris and Heligmosomoides polygyrus. Parasit Vectors. 2022;15:243. DOI: 10.1186/s13071-022-05347-y

Walker M, Freitas L.T, Halder J.B, Brack M, Keiser J, King C.H, Levecke B, Ai-Lian Lim Y, Pieri O, Sow D, Stothard J.R, Webster J.P, Zhou X.N, Terry R.F, Guérin P.J, Basáñez M.G. Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data. Wellcome Open Res. 2022;7:5. DOI: 10.12688/wellcomeopenres.17468.1

Bosch F, Palmeirim M.S, Ali S.M, Ame S.M, Hattendorf J, Keiser J. Diagnosis of soil-transmitted helminths using the Kato-Katz technique: what is the influence of stirring, storage time and storage temperature on stool sample egg counts?. PLoS Negl Trop Dis. 2021;15:e0009032. DOI: 10.1371/journal.pntd.0009032

Brussee J.M, Hiroshige N, Neodo A, Coulibaly J.T, Pfister M, Keiser J. Population pharmacokinetics and exposure-response analysis of tribendimidine to improve treatment for children with hookworm infection. Antimicrob Agents Chemother. 2021;65(2):e01778-20. DOI: 10.1128/AAC.01778-20

Brussee J.M, Neodo A, Schulz J.D, Coulibaly J.T, Pfister M, Keiser J. Pharmacometric analysis of tribendimidine mono- and combination therapies to achieve high cure rates in patients with hookworm infections. Antimicrob Agents Chemother. 2021;65(2):e00714-20. DOI: 10.1128/AAC.00714-20

Buchter V, Hofmann D, Häberli C, Keiser J. Characterization of moxidectin against Strongyloides ratti: in vitro and in vivo activity and pharmacokinetics in the rat model. ACS Infect Dis. 2021;7(5):1069-1076. DOI: 10.1021/acsinfecdis.0c00435

Buchter V, Schneeberger P.H.H, Keiser J. Validation of a human-serum-based in vitro growth method for drug screening on juvenile development stages of Schistosoma mansoni. PLoS Negl Trop Dis. 2021;15(3):e0009313. DOI: 10.1371/journal.pntd.0009313

Debbert S.L, Hintz M.J, Bell C.J, Earl K.R, Forsythe G.E, Häberli C, Keiser J. Activities of quinoxaline, nitroquinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against Schistosoma mansoni. Antimicrob Agents Chemother. 2021;65(3):e01370-20. DOI: 10.1128/AAC.01370-20

Dube M, Saoud M, Rennert R, Fotso G.W, Andrae-Marobela K, Imming P, Häberli C, Keiser J, Arnold N. Anthelmintic activity and cytotoxic effects of compounds isolated from the fruits of Ozoroa insignis del. (Anacardiaceae). Biomolecules. 2021;11(12):1893. DOI: 10.3390/biom11121893

Hofmann D, Sayasone S, Keiser J. Development and validation of an LC-MS/MS method for the quantification of the anthelmintic drug moxidectin in a volumetric absorptive microsample, blood, and plasma: application to a pharmacokinetic study of adults infected with Strongyloides stercor. J Chromatogr B Analyt Technol Biomed Life Sci. 2021;1166:122556. DOI: 10.1016/j.jchromb.2021.122556