Publications
Ajayi D.T, Orherhe O.M, Pillai G.C, Mouksassi S, Steffens B, Bräm D, Sprecher V, Hofmann D, Buettcher M, Coulibaly J.T, Ali S.M, Keiser J, Pfister M. Pharmacometric analysis to describe pharmacokinetics and exposure-efficacy response of ivermectin in adolescents infected with Trichuris trichiura. J Clin Pharmacol. 2025;65(4):433-440. DOI: 10.1002/jcph.6158
Dupouy B, Karpstein T, Häberli C, Cal M, Rottmann M, Mäser P, Keiser J, Elhabiri M, Davioud-Charvet E. Synthesis of 1,2,3-triazole-methyl-menadione derivatives: evaluation of electrochemical and antiparasitic properties against two blood-dwelling parasites. ChemMedChem. 2025;20(6):e202400731. DOI: 10.1002/cmdc.202400731
Dziwornu G.A, Attram H.D, Häberli C, Masike K, Njoroge M, Keiser J. Benzimidazole analogues active against adult Schistosoma mansoni: SAR analyses, in vivo efficacy in mice, and preliminary mechanistic studies as potential inhibitors of hemozoin formation. Eur J Med Chem. 2025;284:117186. DOI: 10.1016/j.ejmech.2024.117186
Lo N.C, Addiss D.G, Buonfrate D, Amor A, Anegagrie M, Bisoffi Z, Bradbury R.S, Keiser J, Kepha S, Khieu V, Krolewiecki A, Mbonigaba J.B, Muñoz J, Mutapi F, Novela V, Vaz Nery S, Coffeng L.E, de Vlas S.J, Bartoszko J, Moja L, Mupfasoni D, Montresor A. Review of the WHO guideline on preventive chemotherapy for public health control of strongyloidiasis. Lancet Infect Dis. 2025;25(3):e146-e152. DOI: 10.1016/s1473-3099(24)00595-4
Lotz C.N, Mrimi E.C, Schneeberger P.H.H, Ali S.M, Hattendorf J, Keiser J. Performance of real-time polymerase chain reaction and Kato-Katz for diagnosing soil-transmitted helminth infections and evaluating treatment efficacy of emodepside in randomized controlled trials. PLoS Negl Trop Dis. 2025;19(2):e0012872. DOI: 10.1371/journal.pntd.0012872
Lotz C.N, Schneeberger P.H.H, Concu M, Ali S.M, Mrimi E.C, Keiser J. Implementation of real-time PCR assays for diagnosing intestinal protozoa infections. Parasitol Res. 2025;124(4):40. DOI: 10.1007/s00436-025-08483-3
Malan D, Van Niekerk S, Häberli C, Keiser J, Van der Kooy F. In vitro antischistosomal activity of Artemisia species. Acta Trop. 2025;262:107535. DOI: 10.1016/j.actatropica.2025.107535
Ueberall M.E, Berchthold M, Häberli C, Lindemann S, Spangenberg T, Keiser J, Grevelding C.G. Merck Open Global Health Library in vitro screening against Schistosoma mansoni identified two new substances with antischistosomal activities for further development. Parasit Vectors. 2025;18:40. DOI: 10.1186/s13071-024-06648-0
Venkatesan A, Chen R, Bär M, Schneeberger P.H.H, Reimer B, Hürlimann E, Coulibaly J.T, Ali S.M, Sayasone S, Soghigian J, Keiser J, Gilleard J.S. Trichuriasis in human patients from Côte d'Ivoire caused by novel Trichuris incognita species with low sensitivity to albendazole/ivermectin combination treatment. Emerg Infect Dis. 2025;31(1):104-114. DOI: 10.3201/eid3101.240995
Brooker S.J, Keiser J, Bundy D.A.P. Soil-transmitted helminths (geohelminths). In: Farrar J,Hotez P.J,Junghanss T,Kang G,Lalloo D,White N.J,Garcia P.J, eds. Manson's Tropical Diseases, 772-796. Amsterdam: Elsevier, 2024. DOI: 10.1016/B978-0-7020-7959-7.00060-9
Book Section
Cesar-Rodo E, Dupouy B, Häberli C, Strub J.M, Williams D.L, Mäser P, Rottmann M, Keiser J, Lanfranchi D.A, Davioud-Charvet E. Regioselective synthesis of potential non-quinonoid prodrugs of plasmodione: antiparasitic properties against two hemoglobin-feeding parasites and drug metabolism studies. Molecules. 2024;29(22):5268. DOI: 10.3390/molecules29225268
Davie T, Serrat X, Imhof L, Snider J, Štagljar I, Keiser J, Hirano H, Watanabe N, Osada H, Fraser A.G. Identification of a family of species-selective complex I inhibitors as potential anthelmintics. Nat Commun. 2024;15:3367. DOI: 10.1038/s41467-024-47331-3
Dommann J, Keiser J, Garneau J, Gandelin A, Casanova C, Keller P.M, Sayasone S, Vonaesch P, Schneeberger P.H.H. Exposure of gut bacterial isolates to the anthelminthic drugs, ivermectin and moxidectin, leads to antibiotic-like phenotypes of growth inhibition and adaptation. Commun Biol. 2024;7:1566. DOI: 10.1038/s42003-024-07135-z
Dommann J, Kerbl-Knapp J, Albertos Torres D, Egli A, Keiser J, Schneeberger P.H.H. A novel barcoded nanopore sequencing workflow of high-quality, full-length bacterial 16S amplicons for taxonomic annotation of bacterial isolates and complex microbial communities. mSystems. 2024;9(10):e0085924. DOI: 10.1128/msystems.00859-24
Emerson P.M, Evans D, Freeman M.C, Hanson C, Kalua K, Keiser J, Krolewiecki A, Leonard L, Levecke B, Matendechero S, Means A.R, Montresor A, Mupfasoni D, Pullan R.L, Rotondo L.A, Stephens M, Sullivan K.M, Walson J.L, Williams T, Utzinger J. Need for a paradigm shift in soil-transmitted helminthiasis control: targeting the right people, in the right place, and with the right drug(s). PLoS Negl Trop Dis. 2024;18(10):e0012521. DOI: 10.1371/journal.pntd.0012521
Fuchs N, Zimmermann R.A, Schwickert M, Gunkel A, Zimmer C, Meta M, Schwickert K, Keiser J, Häberli C, Kiefer W, Schirmeister T. Dual strategy to design new agents targeting Schistosoma mansoni: advancing phenotypic and SmCB1 inhibitors for improved efficacy. ACS Infect Dis. 2024;10(5):1664-1678. DOI: 10.1021/acsinfecdis.4c00020
González Cabrera D, Keiser J, Spangenberg T. Analysis of the physicochemical properties of anti-schistosomal compounds to identify next-generation leads. ACS Med Chem Lett. 2024;15(5):626-630. DOI: 10.1021/acsmedchemlett.4c00026
Gordon C.A, Utzinger J, Muhi S, Becker S.L, Keiser J, Khieu V, Gray D.J. Strongyloidiasis. Nat Rev Dis Primers. 2024;10:6. DOI: 10.1038/s41572-023-00490-x
Grolimund C.M, Utzinger J, Coulibaly J.T, Sayasone S, Ali S.M, Keiser J, Vounatsou P. Modeling transmission mechanism to infer treatment efficacy of different drugs and combination therapy against Trichuris trichiura. Sci Rep. 2024;14:23543. DOI: 10.1038/s41598-024-73164-7
Keiser J, Bouchery T. A step forward in the journey towards hookworm vaccines. Lancet Infect Dis. 2024;24(7):673-674. DOI: 10.1016/s1473-3099(24)00145-2
Kuevi D.N.O, Keiser J, Häberli C, Owusu-Senyah A.K, Ahiabu M.K. In vitro antischistosomal activity of Bridelia ferruginea, Clausena anisata, Khaya senegalensis, and Vernonia amygdalina. J Trop Med. 2024;2024(1):8074291. DOI: 10.1155/2024/8074291
Leas D.A, Keiser J, Charman S.A, Shackleford D.M, Jones J.O, Campbell M, Chen G, Katneni K, Patil R, Hu M, Pham T, Häberli C, Schulze T.T, Neville A.J, Wang X, Dong Y, Davis P.H, Vennerstrom J.L. Single-dose drug development candidate for schistosomiasis. ACS Infect Dis. 2024;10(11):3963-3972. DOI: 10.1021/acsinfecdis.4c00677
Lotz C.N, Krollenbrock A, Imhof L, Riscoe M, Keiser J. Robenidine derivatives as potential antischistosomal drug candidates. Int J Parasitol Drugs Drug Resist. 2024;25:100546. DOI: 10.1016/j.ijpddr.2024.100546
Palmeirim M.S, Hürlimann E, Beinamaryo P, Kyarisiima H, Nabatte B, Hattendorf J, Steinmann P, Keiser J. Efficacy and safety of albendazole alone versus albendazole in combination with ivermectin for the treatment of Trichuris trichiura infections: an open-label, randomized controlled superiority trial in south-western Uganda. PLoS Negl Trop Dis. 2024;18(11):e0012687. DOI: 10.1371/journal.pntd.0012687
Pillay-Fuentes Lorente V, Nwogu-Attah J.N, Steffens B, Bräm D, Sprecher V, Hofmann D, Buettcher M, Pillai G, Mouksassi S, Coulibaly J, Pfister M, Keiser J. Understanding drug exposure and Trichuris trichiura cure rates: a pharmacometric approach for albendazole-ivermectin co-medication in Tanzania and Côte d'Ivoire. Drugs R D. 2024;24(2):331-340. DOI: 10.1007/s40268-024-00476-4
Qian M.B, Keiser J, Utzinger J, Zhou X.N. Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control. Clin Microbiol Rev. 2024;37(1):e0000923. DOI: 10.1128/cmr.00009-23
Ren R, Leas D.A, Häberli C, Cal M, Chen G, Katneni K, Dong Y, Kaiser M, Keiser J, Charman S.A, Vennerstrom J.L. Medium-ring keto bislactams with antischistosomal activity. J Med Chem. 2024;67(20):18235-18246. DOI: 10.1021/acs.jmedchem.4c01532
Shanley H.T, Taki A.C, Nguyen N, Wang T, Byrne J.J, Ang C.S, Leeming M.G, Nie S, Williamson N, Zheng Y, Young N.D, Korhonen P.K, Hofmann A, Chang B.C.H, Wells T.N.C, Häberli C, Keiser J, Jabbar A, Sleebs B.E, Gasser R.B. Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity. Int J Parasitol Drugs Drug Resist. 2024;24:100522. DOI: 10.1016/j.ijpddr.2024.100522
Sprecher V.P, Hofmann D, Savathdy V, Xayavong P, Norkhankhame C, Huy R, Khieu V, Sayasone S, Hattendorf J, Keiser J. Efficacy and safety of moxidectin compared with ivermectin against Strongyloides stercoralis infection in adults in Laos and Cambodia: a randomised, double-blind, non-inferiority, phase 2b/3 trial. Lancet Infect Dis. 2024;24(2):196-205. DOI: 10.1016/s1473-3099(23)00507-8
Stettler M, Lotz C, Probst A, Marreros N, Lundström-Stadelmann B, Frey C.F, Keiser J, Hofer A, Hoby S. Safety and pharmacokinetics of praziquantel in European pond turtles (Emys orbicularis). J Zoo Wildl Med. 2024;54(4):728-737. DOI: 10.1638/2023-0031
Taylor L, Ahmada A.A, Ali M.S, Ali S.M, Hattendorf J, Mohammed I.S, Keiser J. Efficacy and safety of emodepside compared with albendazole in adolescents and adults with hookworm infection in Pemba Island, Tanzania: a double-blind, superiority, phase 2b, randomised controlled trial. Lancet. 2024;404(10453):683-691. DOI: 10.1016/s0140-6736(24)01403-x
Vaillant M.T, Philippy F, Neven A, Barré J, Bulaev D, Olliaro P.L, Utzinger J, Keiser J, Garba A.T. Diagnostic tests for human Schistosoma mansoni and Schistosoma haematobium infection: a systematic review and meta-analysis. Lancet Microbe. 2024;5:e366-e378. DOI: 10.1016/s2666-5247(23)00377-4
van Beek A.E, Jeanguenat H, Häberli C, Pouw R.B, Lamers C, Pál G, Gál P, Schmidt C.Q, Ricklin D, Keiser J. Praziquantel and factor H recruitment differentially affect the susceptibility of Schistosoma mansoni to complement-mediated damage. Front Immunol. 2024;15:1474358. DOI: 10.3389/fimmu.2024.1474358
Welsche S, Schneeberger P.H.H, Hattendorf J, Sayasone S, Hürlimann E, Keiser J. Egg excretion patterns of soil-transmitted helminth infections in humans following albendazole-ivermectin and albendazole treatment. PLoS Negl Trop Dis. 2024;18(3):e0012073. DOI: 10.1371/journal.pntd.0012073
Biendl S, Häberli C, Chen G, Wang W, Zhong L, Saunders J, Pham T, Wang X, Wu J, Charman S.A, Vennerstrom J.L, Keiser J. In vitro and in vivo antischistosomal activity profiling and pharmacokinetics of ozonide carboxylic acids. ACS Infect Dis. 2023;9(3):643-652. DOI: 10.1021/acsinfecdis.2c00581
Cappuccino C, Spoletti E, Renni F, Muntoni E, Keiser J, Voinovich D, Perissutti B, Lusi M. Co-crystalline solid solution affords a high-soluble and fast-absorbing form of praziquantel. Mol Pharm. 2023;20(4):2009-2016. DOI: 10.1021/acs.molpharmaceut.2c00984
Coffeng L.E, Vlaminck J, Cools P, Denwood M, Albonico M, Ame S.M, Ayana M, Dana D, Cringoli G, de Vlas S.J, Fenwick A, French M, Kazienga A, Keiser J, Knopp S, Leta G, Matoso L.F, Maurelli M.P, Montresor A, Mirams G, Mekonnen Z, Corrêa-Oliveira R, Pinto S.A, Rinaldi L, Sayasone S, Steinmann P, Thomas E, Vercruysse J, Levecke B. A general framework to support cost-efficient fecal egg count methods and study design choices for large-scale STH deworming programs-monitoring of therapeutic drug efficacy as a case study. PLoS Negl Trop Dis. 2023;17(5):e0011071. DOI: 10.1371/journal.pntd.0011071
Coulibaly J.T, Silue K.D, Armstrong M, Díaz de León Derby M, D'Ambrosio M.V, Fletcher D.A, Keiser J, Fisher K, Andrews J.R, Bogoch I.I. High sensitivity of mobile phone microscopy screening for Schistosoma haematobium in Azaguié, Côte d'Ivoire. Am J Trop Med Hyg. 2023;108(1):41-43. DOI: 10.4269/ajtmh.22-0527
D'Abbrunzo I, Bianco E, Gigli L, Demitri N, Birolo R, Chierotti M.R, Škorić I, Keiser J, Häberli C, Voinovich D, Hasa D, Perissutti B. Praziquantel meets Niclosamide: a dual-drug antiparasitic cocrystal. Int J Pharm. 2023;644:123315. DOI: 10.1016/j.ijpharm.2023.123315
Easland E, Biendl S, Keiser J. Development of a hookworm egg hatching assay to determine the ovicidal effects of anthelminthics. Parasit Vectors. 2023;16:157. DOI: 10.1186/s13071-023-05771-8
Friedrich L, Park S.K, Ballard P, Ho Baeurle T.H, Maillard D, Bödding M, Keiser J, Marchant J.S, Spangenberg T. Metabolism of (R)-praziquantel versus the activation of a Parasite Transient Receptor Potential Melastatin ion channel. ChemMedChem. 2023;18(18):e202300140. DOI: 10.1002/cmdc.202300140
Hürlimann E, Hofmann D, Keiser J. Ivermectin and moxidectin against soil-transmitted helminth infections. Trends Parasitol. 2023;39(4):272-284. DOI: 10.1016/j.pt.2023.01.009
Kasago F.M, Häberli C, Keiser J, Masamba W. Design, synthesis and evaluation of praziquantel analogues and new molecular hybrids as potential antimalarial and anti-schistosomal agents. Molecules. 2023;28(13):5184. DOI: 10.3390/molecules28135184
Keiser J. Present drugs and future perspectives in treating soil-transmitted helminthiasis. Front Trop Dis. 2023;4:1282725. DOI: 10.3389/fitd.2023.1282725
Journal Article
Mäser P, Bernhard S, Brun R, Burri C, Gagneux S, Hetzel M.W, Kaiser M, Lengeler C, Pluschke G, Reus E, Rottmann M, Utzinger J, Warryn L, Wittlin S, Keiser J. Key contributions by the Swiss Tropical and Public Health Institute towards new and better drugs for tropical diseases. Chimia (Aarau). 2023;77(9):593-606. DOI: 10.2533/chimia.2023.593
Meier L, Antillón M, Burri C, Chitnis N, Endriss Y, Keiser J, Moore S, Müller P, Penny M, Voss T.S, Mäser P, Utzinger J. Repurposing know-how for drug development: case studies from the Swiss Tropical and Public Health Institute. Chimia (Aarau). 2023;77(9):582-592. DOI: 10.2533/chimia.2023.582
Mrimi E.C, Palmeirim M.S, Minja E.G, Long K.Z, Keiser J. Correlation of cytokines with parasitic infections, undernutrition and micronutrient deficiency among schoolchildren in rural Tanzania: a cross-sectional study. Nutrients. 2023;15(8):1916. DOI: 10.3390/nu15081916
Mrimi E.C, Welsche S, Ali S.M, Hattendorf J, Keiser J. Emodepside for Trichuris trichiura and hookworm infection. N Engl J Med. 2023;388(20):1863-1875. DOI: 10.1056/NEJMoa2212825
Muya K, Kalonji M, Ilunga N.W, Maseho M, Kitambala M, Kalonda M, Ndoumba K, Byanga K, Wright C.W, Häberli C, Keiser J, Simbi L. Evaluation of 43 species of Congolese medicinal plants used traditionally for the treatment of schistosomiasis leading to the isolation of an anti-schistosomal phaeophytin from Pseudolachnostylis maprouneifolia Pax. J Ethnopharmacol. 2023;315:116688. DOI: 10.1016/j.jep.2023.116688
Noce B, Di Bello E, Zwergel C, Fioravanti R, Valente S, Rotili D, Masotti A, Ansari M.S.Z, Trisciuoglio D, Chakrabarti A, Romier C, Robaa D, Sippl W, Jung M, Häberli C, Keiser J, Mai A. Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages. ChemMedChem. 2023;18(3):e202200510. DOI: 10.1002/cmdc.202200510
Radulov P.S, Yaremenko I.A, Keiser J, Terent'ev A.O. Bridged 1,2,4-trioxolanes: SnCl4-catalyzed synthesis and an in vitro study against S. mansoni. Molecules. 2023;28(13). DOI: 10.3390/molecules28134913
Schärer A, Biendl S, Keiser J. Trichuris muris egg-hatching assay for anthelminthic drug discovery and characterization. Int J Parasitol Drugs Drug Resist. 2023;23:63-70. DOI: 10.1016/j.ijpddr.2023.10.001
Specht S, Keiser J. Helminth infections: enabling the World Health Organization road map. Int J Parasitol. 2023;53(8):411-414. DOI: 10.1016/j.ijpara.2022.10.006
Sprecher V.P, Coulibaly J.T, Hürlimann E, Hattendorf J, Keiser J. Efficacy and safety of moxidectin-albendazole and ivermectin-albendazole combination therapy compared to albendazole monotherapy in adolescents and adults infected with Trichuris trichiura: a randomized controlled superiority trial. Clin Infect Dis. 2023;77(9):1294-1302. DOI: 10.1093/cid/ciad387
Welsche S, Mrimi E.C, Hattendorf J, Hürlimann E, Ali S.M, Keiser J. Efficacy and safety of moxidectin and albendazole compared with ivermectin and albendazole coadministration in adolescents infected with Trichuris trichiura in Tanzania: an open-label, non-inferiority, randomised, controlled, phase 2/3 trial. Lancet Infect Dis. 2023;23(3):331-340. DOI: 10.1016/S1473-3099(22)00589-8
Angeli A, Ferraroni M, Carta F, Häberli C, Keiser J, Costantino G, Supuran C.T. Development of praziquantel sulphonamide derivatives as antischistosomal drugs. J Enzyme Inhib Med Chem. 2022;37(1):1479-1494. DOI: 10.1080/14756366.2022.2078970
Biendl S, Häberli C, Keiser J. Discovery of novel antischistosomal scaffolds from the open access Pandemic Response Box. Expert Rev Anti Infect Ther. 2022;20(4):621-629. DOI: 10.1080/14787210.2022.1990042
Cantara A, Luo Y, Dobrovolna M, Bohalova N, Fojta M, Verga D, Guittat L, Cucchiarini A, Savrimoutou S, Häberli C, Guillon J, Keiser J, Brazda V, Mergny J.L. G-quadruplexes in helminth parasites. Nucleic Acids Res. 2022;50(5):2719-2735. DOI: 10.1093/nar/gkac129
Coulibaly J.T, Hürlimann E, Patel C, Silué D.K, Avenié D.J, Kouamé N.A, Silué U.M, Keiser J. Optimizing implementation of preventive chemotherapy against soil-transmitted helminthiasis and intestinal schistosomiasis using high-resolution data: field-based experiences from Côte d'Ivoire. Diseases. 2022;10(4):66. DOI: 10.3390/diseases10040066
Di Bello E, Noce B, Fioravanti R, Zwergel C, Valente S, Rotili D, Fianco G, Trisciuoglio D, Mourão M.M, Sales P. Jr, Lamotte S, Prina E, Späth G.F, Häberli C, Keiser J, Mai A. Effects of structurally different HDAC inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni. ACS Infect Dis. 2022;8(7):1356-1366. DOI: 10.1021/acsinfecdis.2c00232
Dube M, Llanes D, Saoud M, Rennert R, Imming P, Häberli C, Keiser J, Arnold N. Albatrellus confluens (Alb. & Schwein.) Kotl. & Pouz.: natural fungal compounds and synthetic derivatives with in vitro anthelmintic activities and antiproliferative effects against two human cancer cell lines. Molecules. 2022;27(9):2950. DOI: 10.3390/molecules27092950
Dube M, Raphane B, Sethebe B, Seputhe N, Tiroyakgosi T, Imming P, Häberli C, Keiser J, Arnold N, Andrae-Marobela K. Medicinal plant preparations administered by Botswana traditional health practitioners for treatment of worm infections show anthelmintic activities. Plants (Basel). 2022;11(21):2945. DOI: 10.3390/plants11212945
Falcoz C, Guzy S, Kovač J, Meister I, Coulibaly J, Sayasone S, Wesche D, Lin Y.W, Keiser J. R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini. J Pharmacokinet Pharmacodyn. 2022;49(3):293-310. DOI: 10.1007/s10928-021-09791-8
Falcoz C, Guzy S, Kovac J, Meister I, Coulibaly J, Sayasone S, Wesche D, Lin Y.W, Keiser J. Correction to: R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini. J Pharmacokinet Pharmacodyn. 2022;49(3):395. DOI: 10.1007/s10928-022-09807-x
Grolimund C.M, Bärenbold O, Utzinger J, Keiser J, Vounatsou P. Modeling the effect of different drugs and treatment regimen for hookworm on cure and egg reduction rates taking into account diagnostic error. PLoS Negl Trop Dis. 2022;16(10):e0010810. DOI: 10.1371/journal.pntd.0010810
Hamway Y, Zimmermann K, Blommers M.J.J, Sousa M, Häberli C, Kulkarni S, Skalicky S, Hackl M, Götte M, Keiser J, da Costa C.P, Spangenberg T, Azzaoui K. Modulation of host-parasite interactions with small molecules targeting Schistosoma mansoni microRNAs. ACS Infect Dis. 2022;8:2028−2034. DOI: 10.1021/acsinfecdis.2c00360
Harrington S, Knox J.J, Burns A.R, Choo K.L, Au A, Kitner M, Häberli C, Pyche J, D'Amata C, Kim Y.H, Volpatti J.R, Guiliani M, Snider J, Wong V, Palmeira B.M, Redman E.M, Vaidya A.S, Gilleard J.S, Stagljar I, Cutler S.R, Kulke D, Dowling J.J, Yip C.M, Keiser J, Zasada I, Lautens M, Roy P.J. Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release. Commun Biol. 2022;5:865. DOI: 10.1038/s42003-022-03819-6
Hassan M.M, Sedighi A, Olaoye O.O, Häberli C, Merz A, Ramos-Morales E, de Araujo E.D, Romier C, Jung M, Keiser J, Gunning P.T. Phenotypic screening of histone deacetylase (HDAC) inhibitors against Schistosoma mansoni. ChemMedChem. 2022:e202100622. DOI: 10.1002/cmdc.202100622
Herath H.M.P.D, Taki A.C, Rostami A, Jabbar A, Keiser J, Geary T.G, Gasser R.B. Whole-organism phenotypic screening methods used in early-phase anthelmintic drug discovery. Biotechnol Adv. 2022;57:107937. DOI: 10.1016/j.biotechadv.2022.107937
Hofmann D, Brussee J.M, Schulz J.D, Coulibaly J.T, Pfister M, Keiser J. Pharmacokinetic modelling and simulation to optimize albendazole dosing in hookworm- or Trichuris trichiura-infected infants to adults. J Antimicrob Chemother. 2022;77(4):1082-1093. DOI: 10.1093/jac/dkac020
Hofmann D, Smit C, Sayasone S, Pfister M, Keiser J. Optimizing moxidectin dosing for Strongyloides stercoralis infections: insights from pharmacometric modeling. Clin Transl Sci. 2022;15(3):700-708. DOI: 10.1111/cts.13189
Hürlimann E, Keller L, Patel C, Welsche S, Hattendorf J, Ali S.M, Ame S.M, Sayasone S, Coulibaly J.T, Keiser J. Efficacy and safety of co-administered ivermectin and albendazole in school-aged children and adults infected with Trichuris trichiura in Côte d'Ivoire, Laos, and Pemba Island, Tanzania: a double-blind, parallel-group, phase 3, randomised control. Lancet Infect Dis. 2022;22(1):123-135. DOI: 10.1016/S1473-3099(21)00421-7
Kersting L, Kuhn L, Anokhin M, Schuster F, Häberli C, Sambyal S, Kumar H.M.S, Keiser J, Alabugin I, Tsogoeva S.B. Visible-light-driven metal-free C-H functionalization: access to new bioactive tetrahydroisoquinoline-butenolide hybrids via domino amine oxidation/vinylogous Mannich reaction. ChemPhotoChem. 2022;6(8):e202200109. DOI: 10.1002/cptc.202200109
Journal Article
Mrimi E.C, Palmeirim M.S, Minja E.G, Long K.Z, Keiser J. Malnutrition, anemia, micronutrient deficiency and parasitic infections among schoolchildren in rural Tanzania. PLoS Negl Trop Dis. 2022;16(3):e0010261. DOI: 10.1371/journal.pntd.0010261
Olliaro P.L, Vaillant M.T, Diawara A, Speich B, Albonico M, Utzinger J, Keiser J. Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment. PLoS Negl Trop Dis. 2022;16(8):e0010593. DOI: 10.1371/journal.pntd.0010593
Probst A, Biendl S, Keiser J. Improving translational power in antischistosomal drug discovery. Adv Parasitol. 2022;117:47-73. DOI: 10.1016/bs.apar.2022.05.002
Probst A, Hofmann D, Fedorova O.S, Mazeina S.V, Sokolova T.S, Golovach E, Keiser J. Pharmacokinetics of ascending doses of praziquantel in adults infected with Opisthorchis felineus in Western Siberia, Russian Federation. Antimicrob Agents Chemother. 2022;66(10):e00526-22. DOI: 10.1128/aac.00526-22
Qian M.B, Patel C, Palmeirim M.S, Wang X, Schindler C, Utzinger J, Zhou X.N, Keiser J. Efficacy of drugs against clonorchiasis and opisthorchiasis: a systematic review and network meta-analysis. Lancet Microbe. 2022;3(8):e616-e624. DOI: 10.1016/S2666-5247(22)00026-X
Ravaynia P.S, Biendl S, Grassi F, Keiser J, Hierlemann A, Modena M.M. Real-time and automated monitoring of antischistosomal drug activity profiles for screening of compound libraries. iScience. 2022;25(4):104087. DOI: 10.1016/j.isci.2022.104087
Ren R, Wang X, Leas D.A, Häberli C, Cal M, Dong Y, Kaiser M, Keiser J, Vennerstrom J.L. Antischistosomal tetrahydro-γ-carboline sulfonamides. Bioorg Med Chem Lett. 2022;59:128546. DOI: 10.1016/j.bmcl.2022.128546
Schneeberger P.H.H, Gueuning M, Welsche S, Hürlimann E, Dommann J, Häberli C, Frey J.E, Sayasone S, Keiser J. Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases. Nat Commun. 2022;13:1063. DOI: 10.1038/s41467-022-28658-1
Smit C, Hofmann D, Sayasone S, Keiser J, Pfister M. Characterization of the population pharmacokinetics of moxidectin in adults infected with Strongyloides stercoralis: support for a fixed-dose treatment regimen. Clin Pharmacokinet. 2022;61:123-132. DOI: 10.1007/s40262-021-01048-4
Taki A.C, Wang T, Nguyen N.N, Ang C.S, Leeming M.G, Nie S, Byrne J.J, Young N.D, Zheng Y, Ma G, Korhonen P.K, Koehler A.V, Williamson N.A, Hofmann A, Chang B.C.H, Häberli C, Keiser J, Jabbar A, Sleebs B.E, Gasser R.B. Thermal proteome profiling reveals Haemonchus orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868. Front Pharmacol. 2022;13:1014804. DOI: 10.3389/fphar.2022.1014804
Taljaard L, Probst A, Tornow R, Keiser J, Haynes R.K, van der Kooy F. In vitro antischistosomal activity of Artemisia annua and Artemisia afra extracts. Phytomed Plus. 2022;2(3):100279. DOI: 10.1016/j.phyplu.2022.100279
Journal Article
Valderas-García E, Häberli C, Álvarez-Bardón M, Escala N, Castilla-Gómez de Agüero V, de la Vega J, Del Olmo E, Balaña-Fouce R, Keiser J, Martínez-Valladares M. Benzimidazole and aminoalcohol derivatives show in vitro anthelmintic activity against Trichuris muris and Heligmosomoides polygyrus. Parasit Vectors. 2022;15:243. DOI: 10.1186/s13071-022-05347-y
Walker M, Freitas L.T, Halder J.B, Brack M, Keiser J, King C.H, Levecke B, Ai-Lian Lim Y, Pieri O, Sow D, Stothard J.R, Webster J.P, Zhou X.N, Terry R.F, Guérin P.J, Basáñez M.G. Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data. Wellcome Open Res. 2022;7:5. DOI: 10.12688/wellcomeopenres.17468.1
Bosch F, Palmeirim M.S, Ali S.M, Ame S.M, Hattendorf J, Keiser J. Diagnosis of soil-transmitted helminths using the Kato-Katz technique: what is the influence of stirring, storage time and storage temperature on stool sample egg counts?. PLoS Negl Trop Dis. 2021;15:e0009032. DOI: 10.1371/journal.pntd.0009032
Brussee J.M, Hiroshige N, Neodo A, Coulibaly J.T, Pfister M, Keiser J. Population pharmacokinetics and exposure-response analysis of tribendimidine to improve treatment for children with hookworm infection. Antimicrob Agents Chemother. 2021;65(2):e01778-20. DOI: 10.1128/AAC.01778-20
Brussee J.M, Neodo A, Schulz J.D, Coulibaly J.T, Pfister M, Keiser J. Pharmacometric analysis of tribendimidine mono- and combination therapies to achieve high cure rates in patients with hookworm infections. Antimicrob Agents Chemother. 2021;65(2):e00714-20. DOI: 10.1128/AAC.00714-20
Buchter V, Hofmann D, Häberli C, Keiser J. Characterization of moxidectin against Strongyloides ratti: in vitro and in vivo activity and pharmacokinetics in the rat model. ACS Infect Dis. 2021;7(5):1069-1076. DOI: 10.1021/acsinfecdis.0c00435
Buchter V, Schneeberger P.H.H, Keiser J. Validation of a human-serum-based in vitro growth method for drug screening on juvenile development stages of Schistosoma mansoni. PLoS Negl Trop Dis. 2021;15(3):e0009313. DOI: 10.1371/journal.pntd.0009313
Debbert S.L, Hintz M.J, Bell C.J, Earl K.R, Forsythe G.E, Häberli C, Keiser J. Activities of quinoxaline, nitroquinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against Schistosoma mansoni. Antimicrob Agents Chemother. 2021;65(3):e01370-20. DOI: 10.1128/AAC.01370-20
Dube M, Saoud M, Rennert R, Fotso G.W, Andrae-Marobela K, Imming P, Häberli C, Keiser J, Arnold N. Anthelmintic activity and cytotoxic effects of compounds isolated from the fruits of Ozoroa insignis del. (Anacardiaceae). Biomolecules. 2021;11(12):1893. DOI: 10.3390/biom11121893
Hofmann D, Sayasone S, Keiser J. Development and validation of an LC-MS/MS method for the quantification of the anthelmintic drug moxidectin in a volumetric absorptive microsample, blood, and plasma: application to a pharmacokinetic study of adults infected with Strongyloides stercor. J Chromatogr B Analyt Technol Biomed Life Sci. 2021;1166:122556. DOI: 10.1016/j.jchromb.2021.122556
Hofmann D, Sayasone S, Sengngam K, Chongvilay B, Hattendorf J, Keiser J. Efficacy and safety of ascending doses of moxidectin against Strongyloides stercoralis infections in adults: a randomised, parallel-group, single-blinded, placebo-controlled, dose-ranging, phase 2a trial. Lancet Infect Dis. 2021;21(8):1151-1160. DOI: 10.1016/S1473-3099(20)30691-5
Jittamala P, Monteiro W, Smit M.R, Pedrique B, Specht S, Chaccour C.J, Dard C, Del Giudice P, Khieu V, Maruani A, Failoc-Rojas V.E, Saez-de-Ocariz M, Soriano-Arandes A, Piquero-Casals J, Faisant A, Brenier-Pinchart M.P, Wimmersberger D, Coulibaly J.T, Keiser J, Boralevi F, Sokana O, Marks M, Engelman D, Romani L, Steer A.C, von Seidlein L, White N.J, Harriss E, Stepniewska K, Humphreys G.S, Kennon K, Guerin P.J, Kobylinski K.C. A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: is it time to reconsider the current contraindication?. PLoS Negl Trop Dis. 2021;15(3):e0009144. DOI: 10.1371/journal.pntd.0009144
Keiser J, Häberli C. Evaluation of commercially available anthelminthics in laboratory models of human intestinal nematode infections. ACS Infect Dis. 2021;7(5):1177-1185. DOI: 10.1021/acsinfecdis.0c00719
Keiser J, Häberli C. Assessment of FDA-approved drugs against Strongyloides ratti in vitro and in vivo to identify potentially active drugs against strongyloidiasis. Parasit Vectors. 2021;14:615. DOI: 10.1186/s13071-021-05117-2
Keller L, Hürlimann E, Patel C, Welsche S, Sayasone S, Ali S.M, Ame S.M, Coulibaly J.T, Keiser J. Insights gained from conductinga randomised controlled trial onIvermectin-albendazole against Trichuris trichiura in Côte d’Ivoire, Lao PDR and Pemba Island. Adv Parasitol. 2021;111:253-276. DOI: 10.1016/bs.apar.2020.11.001
Keller L, Welsche S, Patel C, Sayasone S, Ali S.M, Ame S.M, Hattendorf J, Hürlimann E, Keiser J. Long-term outcomes of ivermectin-albendazole versus albendazole alone against soil-transmitted helminths: results from randomized controlled trials in Lao PDR and Pemba Island, Tanzania. PLoS Negl Trop Dis. 2021;15(6):e0009561. DOI: 10.1371/journal.pntd.0009561
Krücken J, Holden-Dye L, Keiser J, Prichard R.K, Townson S, Makepeace B.L, Hubner M.P, Hahnel S.R, Scandale I, Harder A, Kulke D. Development of emodepside as a possible adulticidal treatment for human onchocerciasis-the fruit of a successful industrial-academic collaboration. PLoS Pathog. 2021;17(7):e1009682. DOI: 10.1371/journal.ppat.1009682
Lombardo F.C, Ravaynia P.S, Modena M.M, Hierlemann A, Keiser J. Evaluation of human liver microtissues for drug screening on Schistosoma mansoni schistosomula. ACS Infect Dis. 2021;7(7):1894-1900. DOI: 10.1021/acsinfecdis.0c00614
Nguyen W, Lee E.F, Evangelista M, Lee M, Harris T.J, Colman P.M, Smith N.A, Williams L.B, Jarman K.E, Lowes K.N, Häberli C, Keiser J, Smith B.J, Fairlie W.D, Sleebs B.E. Optimization of benzothiazole and thiazole hydrazones as inhibitors of schistosome bcl-2a. ACS Infect Dis. 2021;7(5):1143-1163. DOI: 10.1021/acsinfecdis.0c00700
Palmeirim M.S, Mohammed U.A, Ross A, Ame S.M, Ali S.M, Keiser J. Evaluation of two communication tools, slideshow and theater, to improve participants' understanding of a clinical trial in the informed consent procedure on Pemba Island, Tanzania. PLoS Negl Trop Dis. 2021;15(5):e0009409. DOI: 10.1371/journal.pntd.0009409
Palmeirim M.S, Mrimi E.C, Minja E.G, Samson A.J, Keiser J. A cross-sectional survey on parasitic infections in schoolchildren in a rural Tanzanian community. Acta Trop. 2021;213:105737. DOI: 10.1016/j.actatropica.2020.105737
Palmeirim M.S, Specht S, Scandale I, Gander-Meisterernst I, Chabicovsky M, Keiser J. Preclinical and clinical characteristics of the trichuricidal drug oxantel pamoate and clinical development plans: a review. Drugs. 2021;81(8):907-921. DOI: 10.1007/s40265-021-01505-1
Partridge F.A, Bataille C.J.R, Forman R, Marriott A.E, Forde-Thomas J, Häberli C, Dinsdale R.L, O'Sullivan J.D.B, Willis N.J, Wynne G.M, Whiteland H, Archer J, Steven A, Keiser J, Turner J.D, Hoffmann K.F, Taylor M.J, Else K.J, Russell A.J, Sattelle D.B. Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni. ACS Infect Dis. 2021;7(5):1260-1274. DOI: 10.1021/acsinfecdis.1c00025
Patel C, Coulibaly J.T, Hofmann D, N'Gbesso Y, Hattendorf J, Keiser J. Efficacy and safety of albendazole in hookworm-infected preschool-aged children, school-aged children and adults in Côte d'Ivoire: a phase II randomized controlled dose-finding trial. Clin Infect Dis. 2021;73(2):e494-e502. DOI: 10.1093/cid/ciaa989
Patel C, Keller L, Welsche S, Hattendorf J, Sayasone S, Ali S.M, Ame S.M, Coulibaly J.T, Hürlimann E, Keiser J. Assessment of fecal calprotectin and fecal occult blood as point-of-care markers for soil-transmitted helminth attributable intestinal morbidity in a case-control substudy conducted in Côte d'Ivoire, Lao PDR and Pemba Island, Tanzania. EClinicalMedicine. 2021;32:100724. DOI: 10.1016/j.eclinm.2021.100724
Probst A, Chisanga K, Dziwornu G.A, Häberli C, Keiser J, Chibale K. Expanding the activity profile of pyrido[1,2-a]benzimidazoles: synthesis and evaluation of novel n(1)-1-phenylethanamine derivatives against Schistosoma mansoni. ACS Infect Dis. 2021;7(5):1032-1043. DOI: 10.1021/acsinfecdis.0c00278
Probst A, Pujol E, Häberli C, Keiser J, Vázquez S. In vitro, in vivo, and ADME evaluation of SF5-containing N,N'-diarylureas as antischistosomal agents. Antimicrob Agents Chemother. 2021;65(10):e0061521. DOI: 10.1128/aac.00615-21
Sirak B, Asres K, Hailu A, Dube M, Arnold N, Häberli C, Keiser J, Imming P. In vitro antileishmanial and antischistosomal activities of anemonin isolated from the fresh leaves of Ranunculus multifidus forsk. Molecules. 2021;26(24):7473. DOI: 10.3390/molecules26247473
Sy I, Margardt L, Ngbede E.O, Adah M.I, Yusuf S.T, Keiser J, Rehner J, Utzinger J, Poppert S, Becker S.L. Identification of adult Fasciola spp. using matrix-assisted laser/desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. Microorganisms. 2021;9:82. DOI: 10.3390/microorganisms9010082
Walker M, Cools P, Albonico M, Ame S.M, Ayana M, Dana D, Keiser J, Matoso L.F, Montresor A, Mekonnen Z, Corrêa-Oliveira R, Pinto S.A, Sayasone S, Vercruysse J, Vlaminck J, Levecke B. Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure. PLoS Negl Trop Dis. 2021;15(10):e0009888. DOI: 10.1371/journal.pntd.0009888
Welsche S, Mrimi E.C, Keller L, Hürlimann E, Hofmann D, Hattendorf J, Ali S.M, Keiser J. Efficacy and safety of moxidectin and albendazole compared to ivermectin and albendazole co-administration in adolescents infected with Trichuris trichiura: a randomized controlled trial protocol. Gates Open Res. 2021;5:106. DOI: 10.12688/gatesopenres.13299.2
Barda B, Schindler C, Wampfler R, Ame S, Ali S.M, Keiser J. Comparison of real-time PCR and the Kato-Katz method for the diagnosis of soil-transmitted helminthiasis and assessment of cure in a randomized controlled trial. BMC Microbiol. 2020;20:298. DOI: 10.1186/s12866-020-01963-9
Buchter V, Ong Y.C, Mouvet F, Ladaycia A, Lepeltier E, Rothlisberger U, Keiser J, Gasser G. Multidisciplinary preclinical investigations on three oxamniquine analogues as novel drug candidates for schistosomiasis. Chemistry. 2020;26:15232 –15241. DOI: 10.1002/chem.202002856
Buchter V, Priotti J, Leonardi D, Lamas M.C, Keiser J. Preparation, physicochemical characterization and in vitro and in vivo activity against Heligmosomoides polygyrus of novel oral formulations of albendazole and mebendazole. J Pharm Sci. 2020;109(5):1819-1826. DOI: 10.1016/j.xphs.2020.02.002
Buchter V, Priotti J, Leonardi D, Lamas M.C, Keiser J. Activity of novel oral formulations of albendazole and mebendazole against Heligmosomoides polygyrus in vitro and in vivo. J Pharm Sci. 2020;109(5):1819-1826. DOI: 10.1016/j.xphs.2020.02.002
De Rycker M, Horn D, Aldridge B, Amewu R.K, Barry C.E, Buckner F.S, Cook S, Ferguson M.A.J, Gobeau N, Herrmann J, Herrling P, Hope W, Keiser J, Lafuente-Monasterio M.J, Leeson P.D, Leroy D, Manjunatha U.H, McCarthy J, Miles T.J, Mizrahi V, Moshynets O, Niles J, Overington J.P, Pottage J, Rao S.P.S, Read K.D, Ribeiro I, Silver L.L, Southern J, Spangenberg T, Sundar S, Taylor C, Van Voorhis W, White N.J, Wyllie S, Wyatt P.G, Gilbert I.H. Setting our sights on infectious diseases. ACS Infect Dis. 2020;6(1):3-13. DOI: 10.1021/acsinfecdis.9b00371
Else K.J, Keiser J, Holland C.V, Grencis R.K, Sattelle D.B, Fujiwara R.T, Bueno L.L, Asaolu S.O, Sowemimo O.A, Cooper P.J. Whipworm and roundworm infections. Nat Rev Dis Primers. 2020;6(1):44. DOI: 10.1038/s41572-020-0171-3
Keiser J, Koch V, Deckers A, Cheung H.T.A, Jung N, Brase S. Naturally occurring cardenolides affecting Schistosoma mansoni. ACS Infect Dis. 2020;6(7):1922-1927. DOI: 10.1021/acsinfecdis.0c00175
Keller L, Palmeirim M.S, Ame S.M, Ali S.M, Puchkov M, Huwyler J, Hattendorf J, Keiser J. Efficacy and safety of ascending dosages of moxidectin and moxidectin-albendazole against Trichuris trichiura in adolescents: a randomized controlled trial. Clin Infect Dis. 2020;70(6):1193-1201. DOI: 10.1093/cid/ciz326
Keller L, Patel C, Welsche S, Schindler T, Hürlimann E, Keiser J. Performance of the Kato-Katz method and real time polymerase chain reaction for the diagnosis of soil-transmitted helminthiasis in the framework of a randomised controlled trial: treatment efficacy and day-to-day variation. Parasit Vectors. 2020;13:517. DOI: 10.1186/s13071-020-04401-x
Levecke B, Cools P, Albonico M, Ame S, Angebault C, Ayana M, Behnke J.M, Bethony J.M, Cringoli G, Dana D, Guillard B, Viet Hoa N.T, Kang G, Kattula D, Keiser J, Kotze A.C, Matoso L.F, Maurelli M.P, McCarthy J.S, Mekonnen Z, Mirams G, Montresor A, Oliveira R.C, Periago M.V, Pinto S.A, Rinaldi L, Sayasone S, Sumo L, Tchuem-Tchuenté L.A, Cam Thach D.T, Thomas E, Zeynudin A, Verweij J.J, Vlaminck J, Vercruysse J. Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR. PLoS Negl Trop Dis. 2020;14(7):e0008296. DOI: 10.1371/journal.pntd.0008296
Lin Y, Ong Y.C, Keller S, Karges J, Bouchene R, Manoury E, Blacque O, Müller J, Anghel N, Hemphill A, Häberli C, Taki A.C, Gasser R.B, Cariou K, Keiser J, Gasser G. Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole. Dalton Trans. 2020;49(20):6616-6626. DOI: 10.1039/d0dt01107j
Moser W, Keiser J, Speich B, Sayasone S, Knopp S, Hattendorf J. One mean to rule them all? The arithmetic mean based egg reduction rate can be misleading when estimating anthelminthic drug efficacy in clinical trials. PLoS Negl Trop Dis. 2020;14(4):e0008185. DOI: 10.1371/journal.pntd.0008185
Olliaro P.L, Coulibaly J.T, Garba A, Halleux C, Keiser J, King C.H, Mutapi F, N'Goran E.K, Raso G, Scherrer A.U, Sousa-Figueiredo J.C, Stete K, Utzinger J, Vaillant M.T. Efficacy and safety of single 40 mg/kg oral praziquantel in the treatment of schistosomiasis in preschool-age versus school-age children: an individual participant data meta-analysis. PLoS Negl Trop Dis. 2020;14(6):e0008277. DOI: 10.1371/journal.pntd.0008277
Palmeirim M.S, Bosch F, Ame S.M, Ali S.M, Hattendorf J, Keiser J. Efficacy, safety and acceptability of a new chewable formulationversusthe solid tablet of mebendazole against hookworm infections in children: an open-label, randomized controlled trial. EClinicalMedicine. 2020;27:100556. DOI: 10.1016/j.eclinm.2020.100556
Palmeirim M.S, Ross A, Obrist B, Mohammed U.A, Ame S.M, Ali S.M, Keiser J. Informed consent procedure in a double blind randomized anthelminthic trial on Pemba Island, Tanzania: do pamphlet and information session increase caregivers knowledge?. BMC Med Ethics. 2020;21:1. DOI: 10.1186/s12910-019-0441-3
Patel C, Coulibaly J.T, Schulz J.D, N'Gbesso Y, Hattendorf J, Keiser J. Efficacy and safety of ascending dosages of albendazole against Trichuris trichiura in preschool-aged children, school-aged children and adults: a multi-cohort randomized controlled trial. EClinicalMedicine. 2020;22:100335. DOI: 10.1016/j.eclinm.2020.100335
Probst A, Häberli C, Siegel D, Huang J, Vigneron S, Ta A.P, Skinner D.E, El-Sakkary N, Momper J.D, Gangoiti J, Dong Y, Vennerstrom J.L, Charman S.A, Caffrey C.R, Keiser J. Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone. J Antimicrob Chemother. 2020:dkaa247. DOI: 10.1093/jac/dkaa247
Ravaynia P.S, Lombardo F.C, Biendl S, Dupuch M.A, Keiser J, Hierlemann A, Modena M.M. Parallelized impedance-based platform for continuous dose-response characterization of antischistosomal drugs. Adv Biosyst. 2020;4(7):e1900304. DOI: 10.1002/adbi.201900304
Twumasi E.B, Akazue P.I, Kyeremeh K, Gwira T.M, Keiser J, Cho-Ngwa F, Flint A, Anibea B, Bonsu E.Y, Amewu R.K, Amoah L.E, Appiah-Opong R, Osei-Safo D. Antischistosomal, antionchocercal and antitrypanosomal potentials of some Ghanaian traditional medicines and their constituents. PLoS Negl Trop Dis. 2020;14(12):e0008919. DOI: 10.1371/journal.pntd.0008919
Vlaminck J, Cools P, Albonico M, Ame S, Ayana M, Dana D, Keiser J, Matoso L.F, Montresor A, Mekonnen Z, Correa-Oliveira R, Pinto S.A, Sayasone S, Vercruysse J, Levecke B. An in-depth report of quality control on Kato-Katz and data entry in four clinical trials evaluating the efficacy of albendazole against soil-transmitted helminth infections. PLoS Negl Trop Dis. 2020;14(9):e0008625. DOI: 10.1371/journal.pntd.0008625
Vlaminck J, Cools P, Albonico M, Ame S, Chanthapaseuth T, Viengxay V, Do Trung D, Osei-Atweneboana M.Y, Asuming-Brempong E, Jahirul Karim M, Al Kawsar A, Keiser J, Khieu V, Faye B, Turate I, Mbonigaba J.B, Ruijeni N, Shema E, Lucianez A, Santiago Nicholls R, Jamsheed M, Mikhailova A, Montresor A, Mupfasoni D, Yajima A, Ngina Mwinzi P, Gilleard J, Prichard R.K, Verweij J.J, Vercruysse J, Levecke B. Piloting a surveillance system to monitor the global patterns of drug efficacy and the emergence of anthelmintic resistance in soil-transmitted helminth control programs: a Starworms study protocol. Gates Open Res. 2020;4:28. DOI: 10.12688/gatesopenres.13115.1
Wagner-Hattler L, Quebatte G, Keiser J, Schoelkopf J, Schleputz C.M, Huwyler J, Puchkov M. Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering. Int J Pharm. 2020;573:118827. DOI: 10.1016/j.ijpharm.2019.118827
Wu J, Wang X, Chiu F.C.K, Häberli C, Shackleford D.M, Ryan E, Kamaraj S, Bulbule V.J, Wallick A.I, Dong Y, White K.L, Davis P.H, Charman S.A, Keiser J, Vennerstrom J.L. Structure-activity relationship of antischistosomal ozonide carboxylic acids. J Med Chem. 2020;63(7):3723-3736. DOI: 10.1021/acs.jmedchem.0c00069
Zanolla D, Hasa D, Arhangelskis M, Schneider-Rauber G, Chierotti M.R, Keiser J, Voinovich D, Jones W, Perissutti B. Mechanochemical formation of racemic praziquantel hemihydrate with improved biopharmaceutical properties. Pharmaceutics. 2020;12(3):289. DOI: 10.3390/pharmaceutics12030289
Albertini B, Perissutti B, Bertoni S, Zanolla D, Franceschinis E, Voinovich D, Lombardo F, Keiser J, Passerini N. Combining mechanochemistry and spray congealing for new praziquantel pediatric formulations in schistosomiasis treatment. Int J Mol Sci. 2019;20(5):1233. DOI: 10.3390/ijms20051233
Bogoch I.I, Speich B, Lo N.C, Moser W, Croll D, Ali S.M, Ame S.M, Utzinger J, Andrews J.R, Keiser J. Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania. PLoS Negl Trop Dis. 2019;13(7):e0007581. DOI: 10.1371/journal.pntd.0007581
Brecht K, Kirchhofer C, Bouitbir J, Trapani F, Keiser J, Krähenbühl S. Exogenous iron increases fasciocidal activity and hepatocellular toxicity of the synthetic endoperoxides OZ78 and MT04. Int J Mol Sci. 2019;20(19):E4880. DOI: 10.3390/ijms20194880
Brussee J.M, Schulz J.D, Coulibaly J.T, Keiser J, Pfister M. Ivermectin dosing strategy to achieve equivalent exposure coverage in children and adults. Clin Pharmacol Ther. 2019;106(3):661-667. DOI: 10.1002/cpt.1456
Cools P, Vlaminck J, Albonico M, Ame S, Ayana M, Jose Antonio B.P, Cringoli G, Dana D, Keiser J, Maurelli M.P, Maya C, Matoso L.F, Montresor A, Mekonnen Z, Mirams G, Correa-Oliveira R, Pinto S.A, Rinaldi L, Sayasone S, Thomas E, Verweij J.J, Vercruysse J, Levecke B. Diagnostic performance of a single and duplicate Kato-Katz, Mini-FLOTAC, FECPAKG2 and qPCR for the detection and quantification of soil-transmitted helminths in three endemic countries. PLoS Negl Trop Dis. 2019;13(8):e0007446. DOI: 10.1371/journal.pntd.0007446
Coulibaly J.T, Hiroshige N, N'Gbesso Y.K, Hattendorf J, Keiser J. Efficacy and safety of ascending dosages of tribendimidine against hookworm infections in children: a randomized controlled trial. Clin Infect Dis. 2019;69(5):845-852. DOI: 10.1093/cid/ciy999
Hürlimann E, Keiser J. A single dose of ivermectin is sufficient for strongyloidiasis. Lancet Infect Dis. 2019;19(11):1150-1151. DOI: 10.1016/S1473-3099(19)30519-5
Karpstein T, Pasche V, Häberli C, Scandale I, Neodo A, Keiser J. Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections. Parasit Vectors. 2019;12:226. DOI: 10.1186/s13071-019-3476-x
Keiser J, Utzinger J. Community-wide soil-transmitted helminth treatment is equity-effective. Lancet. 2019;393(10185):2011-2012. DOI: 10.1016/S0140-6736(18)32981-7
Kyne G.M, Curtis M.P, Keiser J, Woods D.J. Soil-transmitted helminthiasis - challenges with discovery of novel anthelmintics. In: Swinney D.C,Pollastri M.P, eds. Neglected tropical diseases: drug discovery and development. 77, 227-251. Weinheim: Wiley, 2019. DOI: 10.1002/9783527808656.ch9
Book Section
Le T.G, Kundu A, Ghoshal A, Nguyen N.H, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang B.C.H, Garcia-Bustos J, Wells T.N.C, Palmer M.J, Jabbar A, Gasser R.B, Baell J.B. Novel 1-methyl-1 H-pyrazole-5-carboxamide derivatives with potent anthelmintic activity. J Med Chem. 2019;62(7):3367-3380. DOI: 10.1021/acs.jmedchem.8b01790
Le T.G, Kundu A, Ghoshal A, Nguyen N.H, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang B.C.H, Garcia-Bustos J, Wells T.N.C, Palmer M.J, Jabbar A, Gasser R.B, Baell J.B. Structure–activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of Haemonchus contortus development. J Med Chem. 2019;62(2):1036-1053. DOI: 10.1021/acs.jmedchem.8b01789
Lombardo F.C, Pasche V, Panic G, Endriss Y, Keiser J. Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni. Nat Protoc. 2019;14(2):461-481. DOI: 10.1038/s41596-018-0101-y
Lombardo F.C, Perissutti B, Keiser J. Activity and pharmacokinetics of a praziquantel crystalline polymorph in the Schistosoma mansoni mouse model. Eur J Pharm Biopharm. 2019;142:240-246. DOI: 10.1016/j.ejpb.2019.06.029
Maccesi M, Aguiar P.H.N, Pasche V, Padilla M, Suzuki B.M, Montefusco S, Abagyan R, Keiser J, Mourao M.M, Caffrey C.R. Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery. Parasit Vectors. 2019;12:493. DOI: 10.1186/s13071-019-3747-6
Mayoka G, Keiser J, Häberli C, Chibale K. Structure–activity relationship and in vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies of N-aryl 3-trifluoromethyl pyrido[1,2-a]benzimidazoles that are efficacious in a mouse model of schistos. ACS Infect Dis. 2019;5(3):418-429. DOI: 10.1021/acsinfecdis.8b00313
Meister I, Assawasuwannakit P, Vanobberghen F, Penny M, Odermatt P, Sayasone S, Huwyler J, Tarning J, Keiser J. Pooled population pharmacokinetic analysis of tribendimidine for the treatment of Opisthorchis viverrini infections. Antimicrob Agents Chemother. 2019;63(4):e01391-18. DOI: 10.1128/AAC.01391-18
Moser W, Schindler C, Keiser J. Drug combinations against soil-transmitted helminth infections. Adv Parasitol. 2019;103:91-115. DOI: 10.1016/bs.apar.2018.08.002
Neodo A, Schulz J.D, Huwyler J, Keiser J. In vitro and in vivo drug-drug interaction study of the effects of ivermectin and oxantel pamoate on tribendimidine. Antimicrob Agents Chemother. 2019;63(1):e00762-18. DOI: 10.1128/AAC.00762-18
Panic G, Barda B, Kovac J, Coulibaly J.T, Keiser J. Evaluation of the Clinitek®, a point-of-care urinalysis system for the measurement of clinically significant urinary metabolites and detection of haematuria in Schistosoma haematobium infected children in southern Côte d'Ivoire. Parasit Vectors. 2019;12:298. DOI: 10.1186/s13071-019-3555-z
Pasche V, Laleu B, Keiser J. Early antischistosomal leads identified from in vitro and in vivo screening of the Medicines for Malaria Venture pathogen box. ACS Infect Dis. 2019;5(1):102-110. DOI: 10.1021/acsinfecdis.8b00220