Publications

Lombardo F.C, Pasche V, Panic G, Endriss Y, Keiser J. Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni. Nat Protoc. 2019;14(2):461-481. DOI: 10.1038/s41596-018-0101-y

Panic G, Barda B, Kovac J, Coulibaly J.T, Keiser J. Evaluation of the Clinitek®, a point-of-care urinalysis system for the measurement of clinically significant urinary metabolites and detection of haematuria in Schistosoma haematobium infected children in southern Côte d'Ivoire. Parasit Vectors. 2019;12:298. DOI: 10.1186/s13071-019-3555-z

Chawla K, Modena M.M, Ravaynia P.S, Lombardo F.C, Leonhardt M, Panic G, Burgel S.C, Keiser J, Hierlemann A. Impedance-based microfluidic assay for automated antischistosomal drug screening. ACS Sens. 2018;3(12):2613-2620. DOI: 10.1021/acssensors.8b01027

Coulibaly J.T, Panic G, Yapi R.B, Kovac J, Barda B, N'Gbesso Y.K, Hattendorf J, Keiser J. Efficacy and safety of ascending doses of praziquantel against Schistosoma haematobium infection in preschool-aged and school-aged children: a single-blind randomised controlled trial. BMC Med. 2018;16:81. DOI: 10.1186/s12916-018-1066-y

D'Orchymont F, Hess J, Panic G, Jakubaszek M, Gemperle L, Keiser J, Gasser G. Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates. MedChemComm. 2018;9(11):1905-1909. DOI: 10.1039/C8MD00396C

Kovac J, Meister I, Neodo A, Panic G, Coulibaly J.T, Falcoz C, Keiser J. Pharmacokinetics of praziquantel in Schistosoma mansoni and Schistosoma haematobium infected school- and preschool- aged children. Antimicrob Agents Chemother. 2018;62(8):e02253-17. DOI: 10.1128/AAC.02253-17

Kovac J, Panic G, Neodo A, Meister I, Coulibaly J.T, Schulz J.D, Keiser J. Evaluation of a novel micro-sampling device, MitaTM, in comparison to dried blood spots, for analysis of praziquantel in Schistosoma haematobium -infected children in rural Côte d'lvoire. J Pharm Biomed Anal. 2018;151:339-346. DOI: 10.1016/j.jpba.2018.01.030

Panic G, Coulibaly J.T, Harvey N, Keiser J, Swann J. Characterizing the biochemical response to Schistosoma mansoni infection and treatment with praziquantel in preschool and school aged children. J Proteome Res. 2018;17(6):2028-2033. DOI: 10.1021/acs.jproteome.7b00910

Panic G, Keiser J. Acting beyond 2020: better characterization of praziquantel and promising antischistosomal leads. Curr Opin Pharmacol. 2018;42:27-33. DOI: 10.1016/j.coph.2018.06.004

Panić G. Advancing drug discovery and treatment evaluation for schistosomiasis: improved screening, drug repurposing and rescuing, and the metabonomics of praziquantel treatment. Basel: Univ. Basel, 2018. Doctoral Thesis, University of Basel, Faculty of Science DOI: 10.5451/unibas-006849109

Schneeberger P.H.H, Coulibaly J.T, Panic G, Daubenberger C, Gueuning M, Frey J.E, Keiser J. Investigations on the interplays between Schistosoma mansoni, praziquantel and the gut microbiome. Parasit Vectors. 2018;11:168. DOI: 10.1186/s13071-018-2739-2

Bogoch I.I, Coulibaly J.T, Rajchgot J, Andrews J.R, Kovac J, Utzinger J, Panic G, Keiser J. Poor validity of noninvasive hemoglobin measurements by pulse oximetry compared with conventional absorptiometry in children in Côte d'Ivoire. Am J Trop Med Hyg. 2017;96(1):217-220. DOI: 10.4269/ajtmh.16-0505

Coulibaly J.T, Panic G, Silué K.D, Kovac J, Hattendorf J, Keiser J. Efficacy and safety of praziquantel in preschool-aged and school-aged children infected with Schistosoma mansoni: a randomised controlled, parallel-group, dose-ranging, phase 2 trial. Lancet Glob Health. 2017;5(7):e688-e698. DOI: 10.1016/S2214-109X(17)30187-0

Hess J, Panic G, Patra M, Mastrobuoni L, Spingler B, Roy S, Keiser J, Gasser G. Ferrocenyl, ruthenocenyl, and benzyl oxamniquine derivatives with cross-species activity against Schistosoma mansoni and Schistosoma haematobium. ACS Infect Dis. 2017;3(9):645-652. DOI: 10.1021/acsinfecdis.7b00054

Modena M.M, Chawla K, Lombardo F, Bürgel S.C, Panic G, Keiser J, Hierlemann A. Impedance-based detection of Schistosoma mansoni larvae viability for drug screening. IEEE Biomedical Circuits and Systems Conference (BioCAS). Turin: IEEE, 2017:1-4. DOI: 10.1109/BIOCAS.2017.8325227

Panic G, Ruf M.T, Keiser J. Immunohistochemical investigations of treatment with Ro 13-3978, praziquantel, oxamniquine and mefloquine in Schistosoma mansoni-infected mice. Antimicrob Agents Chemother. 2017;61(12):e01142-17. DOI: 10.1128/AAC.01142-17

Flores D, Panic G, Braissant O, Keiser J. A novel isothermal microcalorimetry tool to assess drug effects on Ancylostoma ceylanicum and Necator americanus. Appl Microbiol Biotechnol. 2016;100(2):837-846. DOI: 10.1007/s00253-015-7081-4

Keiser J, Panic G, Adelfio R, Cowan N, Vargas M, Scandale I. Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections. Parasit Vectors. 2016;9:376. DOI: 10.1186/s13071-016-1616-0

Van Voorhis W.C, Adams J.H, Adelfio R, Ahyong V, Akabas M.H, Alano P, Alday A, Aleman Resto Y, Alsibaee A, Alzualde A, Andrews K.T, Avery S.V, Avery V.M, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher L.E, Boyom F.F, Brea J, Brennan M, Burton A, Caffrey C.R, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon B.L, Colon-Lopez D.D, Corbett Y, Crowther G.J, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi J.L, Du A.Y, Duffy S, Abd El-Salam El-Sayed S, Ferdig M.T, Fernandez Robledo J.A, Fidock D.A, Florent I, Fokou P.V, Galstian A, Gamo F.J, Gokool S, Gold B, Golub T, Goldgof G.M, Guha R, Guiguemde W.A, Gural N, Guy R.K, Hansen M.A, Hanson K.K, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes T.B, Huston C, Igarashi I, Ingram-Sieber K, Itoe M.A, Jadhav A, Naranuntarat Jensen A, Jensen L.T, Jiang R.H, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar V.P, Kyle D.E, Lafuente M.J, Landfear S, Lee N, Lee S, Lehane A.M, Li F, Little D, Liu L, Llinas M, Loza M.I, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour N.R, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa A.N, Misra R.N, Moon S, Moore J.P, Morais Rodrigues da Costa F, Muller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo K.K, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe D.M, Poulsen S.A, Pradhan A, Quevedo C, Quinn R.J, Rice C.A, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett N.G, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith D.A, Soldati T, Spitzmuller A, Stamm S.M, Sullivan D.J, Sullivan W, Suresh S, Suzuki B.M, Suzuki Y, Swamidass S.J, Taramelli D, Tchokouaha L.R, Theron A, Thomas D, Tonissen K.F, Townson S, Tripathi A.K, Trofimov V, Udenze K.O, Ullah I, Vallieres C, Vigil E, Vinetz J.M, Voong Vinh P, Vu H, Watanabe N.A, Weatherby K, White P.M, Wilks A.F, Winzeler E.A, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo P.H, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis P.A. Open source drug discovery with the malaria box compound collection for neglected diseases and beyond. PLoS Pathog. 2016;12(7):e1005763. DOI: 10.1371/journal.ppat.1005763

Keiser J, Panic G, Vargas M, Wang C, Dong Y, Gautam N, Vennerstrom J.L. Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal. J Antimicrob Chemother. 2015;70(6):1788-1797. DOI: 10.1093/jac/dkv016

Kovac J, Leonidova A, Meister I, Panic G, Coulibaly J, Huwyler J, Keiser J. Praziquantel dose-finding and pharmacokinetic studies in school-and preschool-aged children infected with S-mansoni. Trop Med Int Health, 2015;20(Suppl. 1):229. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Panic G, Flores D, Ingram-Sieber K, Keiser J. Fluorescence/luminescence-based markers for the assessment of Schistosoma mansoni schistosomula drug assays. Parasit Vectors. 2015;8:624. DOI: 10.1186/s13071-015-1233-3

Panic G, Vargas M, Scandale I, Keiser J. Investigations of an FDA-approved compound library for potential drugs against Schistosoma mansoni. Trop Med Int Health, 2015;20(Suppl. 1):235-236. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Panic G, Vargas M, Scandale I, Keiser J. Activity profile of an FDA-approved compound library against Schistosoma mansoni. PLoS Negl Trop Dis. 2015;9(7):e0003962. DOI: 10.1371/journal.pntd.0003962

Ingram-Sieber K, Cowan N, Panic G, Vargas M, Mansour N.R, Bickle Q.D, Wells T.N, Spangenberg T, Keiser J. Orally active antischistosomal early leads identified from the open access malaria box. PLoS Negl Trop Dis. 2014;8(1):e2610. DOI: 10.1371/journal.pntd.0002610

Panic G, Duthaler U, Speich B, Keiser J. Repurposing drugs for the treatment and control of helminth infections. Int J Parasitol Drugs Drug Resist. 2014;4:185-200. DOI: 10.1016/j.ijpddr.2014.07.002

Panic G, Ingram K, Keiser J. Development of an in vitro drug sensitivity assay based on newly excysted larvae of Echinostoma caproni. Parasit Vectors. 2013;6:237. DOI: 10.1186/1756-3305-6-237