Measles, mumps and rubella: vaccination rate and seroprevalence in 8th grade students of 8 different sites in Switzerland 1995/96 (Publications)
the MMR-vaccination campaign. Within the frame of the SCARPOL Study, the vaccination status of 649, 8th class students was registered and serum samples were collected. The measles, mumps and rubella specific
8,8-dialkyldihydroberberines with potent antiprotozoal activity (Publications)
Semisynthetic 8,8-dialkyldihydroberberines (8,8-DDBs) were found to possess mid- to low-nanomolar potency against Plasmodium falciparum blood-stage parasites, Leishmania donovani intracellular amastigotes [...] forms. For example, 8,8-diethyldihydroberberine chloride (5b) exhibited in vitro IC(50) values of 77, 100, and 5.3 nM against these three parasites, respectively. In turn, two 8,8-dialkylcanadines, obtained [...] by reduction of the corresponding 8,8-DDBs, were much less potent against...
Concentrations of urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in women exposed to woodsmoke in a cookstove intervention study in San Marcos,... (Publications)
association between woodsmoke exposure and biomarkers of DNA oxidation (8-hydroxy-2'-deoxyguanosine [8-OHdG]) and lipid peroxidation (8-isoprostane) among control and intervention stove users. HAP exposure [...] 2 to 2270.0?g/g creatinine (median: 132.6?g/g creatinine) for 8-OHdG and from 0.1 to 4.5?g/g creatinine (median: 0.8?g/g creatinine) for 8-isoprostane among all study subjects (n=84). After controlling [...] exposure assessment from a subset of 45 control and 39 intervention stove...
Measles, mumps and rubella: vaccination rate and seroprevalence in 8th grade students of 8 different sites in Switzerland 1995/96 (Publications)
the MMR-vaccination campaign. Within the frame of the SCARPOL Study, the vaccination status of 649, 8th class students was registered and serum samples were collected. The measles, mumps and rubella specific
8,8-dialkyldihydroberberines with potent antiprotozoal activity (Publications)
Semisynthetic 8,8-dialkyldihydroberberines (8,8-DDBs) were found to possess mid- to low-nanomolar potency against Plasmodium falciparum blood-stage parasites, Leishmania donovani intracellular amastigotes [...] forms. For example, 8,8-diethyldihydroberberine chloride (5b) exhibited in vitro IC(50) values of 77, 100, and 5.3 nM against these three parasites, respectively. In turn, two 8,8-dialkylcanadines, obtained [...] by reduction of the corresponding 8,8-DDBs, were much less potent against...
Concentrations of urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in women exposed to woodsmoke in a cookstove intervention study in San Marcos,... (Publications)
association between woodsmoke exposure and biomarkers of DNA oxidation (8-hydroxy-2'-deoxyguanosine [8-OHdG]) and lipid peroxidation (8-isoprostane) among control and intervention stove users. HAP exposure [...] 2 to 2270.0?g/g creatinine (median: 132.6?g/g creatinine) for 8-OHdG and from 0.1 to 4.5?g/g creatinine (median: 0.8?g/g creatinine) for 8-isoprostane among all study subjects (n=84). After controlling [...] exposure assessment from a subset of 45 control and 39 intervention stove...
Ealamines A-H, a series of naphthylisoquinolines with the rare 7,8'-coupling site, from the Congolese liana <em>Ancistrocladus ealaensis</em>,... (Publications)
are the first 7,8'-linked "hybrid-type" naphthylisoquinoline alkaloids, i.e., 3R-configured and 6-oxygenated in the tetrahydroisoquinoline part. The discovery of such a broad series of 7,8'-coupled naph [...] leaves of the Central African liana Ancistrocladus ealaensis (Ancistrocladaceae), a series of ten 7,8'-coupled naphthylisoquinoline alkaloids were isolated, comprising eight new compounds, named ealamines
Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8(+) T cell responses post SARS-CoV-2 infection (Publications)
responses for the dominant CD4(+) (HLA-DRB1( *)15:01/S191) and CD8(+) (HLA-A( *)02/S691) T cell epitopes. Antigen-specific CD4(+) and CD8(+) T cell responses were asynchronous, with the peak CD4(+) T cell [...] whereas CD8(+) T cells peaked 2 weeks later. These peripheral T cell responses were elevated compared with COVID-19 patients. We also found that previous SARS-CoV-2 infection resulted in decreased CD8(+) T
Chemically diverse <em>S. mansoni</em> HDAC8 inhibitors reduced viability in worm larval and adult stages (Publications)
Schistosoma mansoni HDAC8 is a reliable target to fight schistosomiasis, and several inhibitors have been reported in the literature up to now. Nevertheless, only a few displayed selectivity over the human [...] HDAC inhibitors from our lab, in many cases exhibiting submicromolar/nanomolar potency against smHDAC8 and diverse degrees of selectivity over hHDAC1 and/or hHDAC6. Such compounds were tested against sc
