Searched for "8".

1. Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana <em>Ancistrocladus abbreviatus</em> with inhibitory... (Publications)

   Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana <em>Ancistrocladus abbreviatus</em> with inhibitory activities against <em>Plasmodium falciparum</em> and PANC-1 human pancreatic cancer cells

   Relevance:

   ladaceae), ten new naphthylisoquinoline alkaloids (7a, 7b, 8a, 8b, and 9-14), displaying three different coupling types (5,1', 5,8', and 7,8'), were isolated, among them a series of five 5,1'-linked r [...] s belonging to the rare group of 7,8'-coupled alkaloids. Two of the alkaloids, the ancistrobrevines I (13) and J (14), are only the fourth and fifth examples of 7,8'-linked naphthyldihydroisoquinolines [...] the stereocenter at C-3, which is too far away for...

2. Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana <em>Ancistrocladus abbreviatus</em> with inhibitory... (Publications)

   Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana <em>Ancistrocladus abbreviatus</em> with inhibitory activities against <em>Plasmodium falciparum</em> and PANC-1 human pancreatic cancer cells

   Relevance:

   ladaceae), ten new naphthylisoquinoline alkaloids (7a, 7b, 8a, 8b, and 9-14), displaying three different coupling types (5,1', 5,8', and 7,8'), were isolated, among them a series of five 5,1'-linked r [...] s belonging to the rare group of 7,8'-coupled alkaloids. Two of the alkaloids, the ancistrobrevines I (13) and J (14), are only the fourth and fifth examples of 7,8'-linked naphthyldihydroisoquinolines [...] the stereocenter at C-3, which is too far away for...

3. Phenotypic screening of histone deacetylase (HDAC) inhibitors against <em>Schistosoma mansoni</em> (Publications)

   Phenotypic screening of histone deacetylase (HDAC) inhibitors against <em>Schistosoma mansoni</em>

   Relevance:

   currently available treatment, hence drug resistance poses a major threat. Recently, histone deacetylase 8 (HDAC8) selective inhibitors have been proposed as a viable treatment for schistosomiasis. Herein, we report [...] isozyme-inhibition profiles, including eight HDAC8 inhibitors with > 10-fold selectivity in comparable functional inhibition assays and IC50 values against HDAC8

4. Phenotypic screening of histone deacetylase (HDAC) inhibitors against <em>Schistosoma mansoni</em> (Publications)

   Phenotypic screening of histone deacetylase (HDAC) inhibitors against <em>Schistosoma mansoni</em>

   Relevance:

   currently available treatment, hence drug resistance poses a major threat. Recently, histone deacetylase 8 (HDAC8) selective inhibitors have been proposed as a viable treatment for schistosomiasis. Herein, we report [...] isozyme-inhibition profiles, including eight HDAC8 inhibitors with > 10-fold selectivity in comparable functional inhibition assays and IC50 values against HDAC8

5. <em>N</em>-substituted noscapine derivatives as new antiprotozoal agents: synthesis, antiparasitic activity and molecular docking study (Publications)

   <em>N</em>-substituted noscapine derivatives as new antiprotozoal agents: synthesis, antiparasitic activity and molecular docking study

   Relevance:

   e 4' epimerase (TbUDPGE PDB: 1GY8) as targets for studying the envisaged mechanism of action. Compounds 6j2 and 6b2 displayed excellent docking scores with -8.59 and -8.86kcal/mol for TbTR and TbUDPGE [...] selectivity index (SI) ranged from 0.8 to 13.2. Eight compounds exhibited activity against Plasmodium falciparum K1 strain with IC50 ranging 1.7-6.4microM, and SI values between 2.8 and 10.5 against L6 rat myoblast

6. Abietane diterpenoids from <em>Salvia sahendica</em> - antiprotozoal activity and determination of their absolute configurations (Publications)

   Abietane diterpenoids from <em>Salvia sahendica</em> - antiprotozoal activity and determination of their absolute configurations

   Relevance:

   cells were determined. The IC50 values of the compounds ranged from 0.8 microM to over 8.8 microM against P. falciparum, and from 1.8 microM to over 32.3 microM against T. brucei rhodesiense. The cytotoxic [...] spectroscopic data including 1D and 2D NMR. The absolute configuration of sahandol (7) and sahandone (8) were assigned by comparison of experimental ECD spectra with calculated ECD data, using time-dependent

7. Abietane diterpenoids from <em>Salvia sahendica</em> - antiprotozoal activity and determination of their absolute configurations (Publications)

   Abietane diterpenoids from <em>Salvia sahendica</em> - antiprotozoal activity and determination of their absolute configurations

   Relevance:

   cells were determined. The IC50 values of the compounds ranged from 0.8 microM to over 8.8 microM against P. falciparum, and from 1.8 microM to over 32.3 microM against T. brucei rhodesiense. The cytotoxic [...] spectroscopic data including 1D and 2D NMR. The absolute configuration of sahandol (7) and sahandone (8) were assigned by comparison of experimental ECD spectra with calculated ECD data, using time-dependent

8. <em>N</em>-substituted noscapine derivatives as new antiprotozoal agents: synthesis, antiparasitic activity and molecular docking study (Publications)

   <em>N</em>-substituted noscapine derivatives as new antiprotozoal agents: synthesis, antiparasitic activity and molecular docking study

   Relevance:

   e 4' epimerase (TbUDPGE PDB: 1GY8) as targets for studying the envisaged mechanism of action. Compounds 6j2 and 6b2 displayed excellent docking scores with -8.59 and -8.86kcal/mol for TbTR and TbUDPGE [...] selectivity index (SI) ranged from 0.8 to 13.2. Eight compounds exhibited activity against Plasmodium falciparum K1 strain with IC50 ranging 1.7-6.4microM, and SI values between 2.8 and 10.5 against L6 rat myoblast

9. Sero-prevalence of brucellosis, Q-fever and Rift Valley fever in humans and livestock in Somali Region, Ethiopia (Publications)

   Sero-prevalence of brucellosis, Q-fever and Rift Valley fever in humans and livestock in Somali Region, Ethiopia

   Relevance:

   associated with age (OR = 8.1; 95% CI 2.8-23.7). The individual apparent seroprevalence of RVF was 13.2% (95% CI 8.7-18.8) in humans, 17.9% (95% CI 11.0-27.8) in cattle, 42.6% (95% CI 34.8-50.7) in camels, 6 [...] of Q-fever in livestock was 9.6% (95% CI 5.9-15.1) in cattle, 55.7% (95% CI 46.0-65.0) in camels, 48.8% (95% CI 42.5-55.0) in goats, and 28.9% (95% CI 25.0-33.2) in sheep. In humans, seropositivity of Q-fever [...] camels were seropositive for brucellosis by iELISA. The individual...

10. Sero-prevalence of brucellosis, Q-fever and Rift Valley fever in humans and livestock in Somali Region, Ethiopia (Publications)

    Sero-prevalence of brucellosis, Q-fever and Rift Valley fever in humans and livestock in Somali Region, Ethiopia

    Relevance:

    associated with age (OR = 8.1; 95% CI 2.8-23.7). The individual apparent seroprevalence of RVF was 13.2% (95% CI 8.7-18.8) in humans, 17.9% (95% CI 11.0-27.8) in cattle, 42.6% (95% CI 34.8-50.7) in camels, 6 [...] of Q-fever in livestock was 9.6% (95% CI 5.9-15.1) in cattle, 55.7% (95% CI 46.0-65.0) in camels, 48.8% (95% CI 42.5-55.0) in goats, and 28.9% (95% CI 25.0-33.2) in sheep. In humans, seropositivity of Q-fever [...] camels were seropositive for brucellosis by iELISA. The individual...