Inactivated trivalent influenza vaccination is associated with lower mortality among patients with COVID-19 in Brazil (Publications)
intensive care treatment (95% CI 0.87 to 0.98), 17% lower odds of requiring invasive respiratory support (95% CI 0.77 to 0.88) and 16% lower odds of death (95% CI 0.78 to 0.90). Protective effects were larger
<em>Mycobacterium africanum</em> elicits an attenuated T cell response to early secreted antigenic target, 6 kDa, in patients with tuberculosis and... (Publications)
in patients with tuberculosis (odds ratio [OR], 0.41 [95% confidence interval {CI}, 0.19-0.89]; P = .024) and household contacts (OR, 0.56 [95% CI, 0.38-0.83]; P = .004) infected with M. africanum, compared
Anti-protozoal activity of aporphine and protoberberine alkaloids from <em>Annickia kummeriae</em> (Engl. & Diels) Setten & Maas (Annonaceae) (Publications)
Plasmodium falciparum K1 strain (IC50 0.12 +/- 0.01 mug/ml, selectivity index (SI) of 250, moderate activity against Trypanosoma brucei rhodesiense STIB 900 strain (IC50 2.50 +/- 0.19 mug/ml, SI 12) and mild activity [...] cytotoxicity activity (CC50 30 - > 90 mug/ml), strong to moderate anti-plasmodial activity (IC50 0.08 +/- 0 [...] activity against Leishmania donovani axenic MHOM-ET-67/82 strain (IC50 9.25 +/- 0.54 mug/ml, SI 3.2). Bioassay-guided chromatographic fractionation led to the...
Aerobic and lung performance in premature children with and without chronic lung disease of prematurity (Publications)
CON (P < 0.05). At rest, forced vital capacity was significantly lower in CLD than in PRE (P < 0.05) and CON (P < 0.0005), and FEV1 and FEF25-75 were lower in CLD than CON (P < 0.0005 and P < 0.005, re [...] ). Exercise-induced bronchoconstriction (EIB) was more prevalent among the 2 premature groups (P < 0.05). CONCLUSIONS: Our children 5 to 7 years old born at VLBW or ELBW, with or without CLD, have some
Continuous video-EEG monitoring increases detection rate of nonconvulsive status epilepticus in the ICU (Publications)
implementation of CVEM (p = 0.0546). There was no significant difference in monthly rates of NCSE diagnosis between groups 2 and 1 (difference = 0.78 new diagnosis/month; p = 0.374). Differences between [...] between groups 3 and 2 (2.89; p = 0.0173), between groups 3 and 1 (3.67; p = 0.006) and between group 3 and pooled groups 1 and 2 (3.28; p = 0.002) were statistically significant. Significance: Frequency of NCSE
Health-related quality of life in rural children living in four European countries: the GABRIEL study (Publications)
(74.5; [73.9, 75.0]). Farm children reported higher KINDL-R scores than non-farm children (p = 0.002). Significantly lower scores were observed in children with allergic diseases (p < 0.001), with sleeping [...] sleeping difficulties (p < 0.001) and in overweight children (p = 0.04). The German GABRIEL sample reported higher mean scores (age 7-10 years: 80.1, [79.9, 80.4]; age 11-13 years: 77.1, [74.9, 79.2]) compared [...] compared to the urban KIGGS study (age 7-10 years: 79.0, [78.7-79.3];...
<em>Plasmodium vivax</em> diversity and population structure across four continents (Publications)
separated from all other populations (FST> 0.2). Outside Central Asia FST values were highest (0.11-0.16) between South American and all other populations, and lowest (0.04-0.07) between populations from South-East [...] continents collected in 1999-2008. Diversity was highest in South-East Asia (mean allelic richness 10.0-12.8), intermediate in the South Pacific (8.1-9.9) Madagascar and Sudan (7.9-8.4), and lowest in South
Detection and characterization of drug-resistant conferring genes in <em>Mycobacterium tuberculosis</em> complex strains: a prospective study in two... (Publications)
5%), 10 (0.7%) and 40 (2.6%) were mono-resistant to INH, RIF, and MDR, respectively. We found the Ghana spoligotype to be associated with drug resistance (INH: 22.1%; p = 0.0000, RIF: 6.2%; p = 0.0103, MDR: [...] than Mycobacterium africanum (51.7%) (p = 0.0000) whereas the opposite was true for inhApro mutations; MAF (48.3%) compared to MTBSS (26.7%) (p = 0.0419). We identified possible novel compensatory INH resistance [...] MDR: 4.6%; p = 0.0240) as compared to the Cameroon spoligotype (INH:...
Interaction between gas cooking and GSTM1 null genotype in bronchial responsiveness: results from the European Community Respiratory Health Survey (Publications)
bronchial responsiveness (beta=-0.08, 95% CI -0.40 to 0.25, p=0.648). However, GSTM1 significantly modified this effect (beta for interaction=-0.75, 95% CI -1.16 to -0.33, p=4x10-4), with GSTM1 null subjects
Association between air pollution and rhinitis incidence in two European cohorts (Publications)
NO2: 1.00 [0.91-1.09], for an increase of 5mug.m(-3) of PM2.5: 0.88 [0.73-1.04]). Similar results were found in the two-pollutant model (aIRR for an increase of 10mug.m(-3) of NO2: 1.01 [0.87-1.17], for [...] for an increase of 5mug.m(-3) of PM2.5: 0.87 [0.68-1.08]). Results differed depending on the city, but no regional pattern emerged for any of the pollutants. CONCLUSIONS: This study did not find any consistent
