Epidemiology of malaria in the Papua New Guinean highlands (Publications)
reanalysed. Results The prevalence of malaria infections in the different surveys ranged from 0.0% to 41.8% (median 4.3%) in non-epidemic surveys and 6.6% to 63.2% (median 21.2%, P < 0.001) during epidemics [...] prevalence decreased significantly with altitude, was reduced in people using bed nets [odds ratio (OR) = 0.8, P < 0.001] but increased in those sleeping in garden houses (OR = 1.34, P < 0.001) and travelling to
Prevalence of drug-resistance mutations and HIV-1 subtypes in a HIV-1 infected COHORT in rural Tanzania (Publications)
5%), M184V (2.5%), G190A (1.7%) and M41L, K65KR, K70KR and L74LV (0.8%). In samples from 2009 only K103N (3.3%), M184V and T215FY (0.8%) were detected. Initial frequencies of subtypes C, A, D and recombinants
Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with <em>Fasciola hepatica</em> in sheep (Publications)
samples were analysed with an accuracy for OZ78 and MT04 from 91 to 115% and a precision lower than 8.9%. Bile samples displayed an accuracy between 92 and 101% and a precision up to 12.7%. Bile samples [...] at 0 and 6h post-administration. Plasma mean peak concentration was 11.1µg/ml at 1.5h for OZ78 and 4.8µg/ml at 4.2h for MT04. Mean AUC of OZ78 and MT04 was 6698 and 3567µgmin/ml, respectively. Bile concentration
A tradition and an epidemic: determinants of the campylobacteriosis winter peak in Switzerland (Publications)
meat fondue consumers revealed chicken as the type of meat with the highest risk of disease (mOR 3.8, 95 % CI 1.1-13.5). Most frequently reported signs and symptoms among patients were diarrhoea (98 %) [...] (81 %), fever (66 %), nausea (44 %) and vomiting (34 %). The median perceived disease severity was 8 on a 1-to-10 rating scale. Patients reported a median duration of illness of 7 days and 14 % were h
Discovery and evaluation of thiazinoquinones as anti-protozoal agents (Publications)
and Delta2(3)-glycine analogue 8k exhibited similar anti-Pf activity to 2 but with slightly enhanced selectivity (SI 72 and 93, respectively), while Delta2(3)-phenethylamide 8e (IC50 0.67 muM, SI 78) exhibited
Limited activity and social participation after hospital discharge from leprosy treatment in a hyperendemic area in North Brazil (Publications)
individuals (mean age: 45.8 years old). The paucibacillary operational classification was more common (170; 60.3%). The eye-hand-foot score ranged from 0 to 12 (mean: 0.7). A total of 84 (29.8%) individuals presented
PCR diagnosis of <em>Opisthorchis viverrini</em> and <em>Haplorchis taichui</em> infections in a Lao community in an area of endemicity and comparison... (Publications)
PCR tests of O. viverrini and H. taichui had sensitivities of 93.7% (95% confidence interval [CI], 85.8 to 97.9%) and 73.3% (95% CI, 60.3 to 83.9%) and could detect as little as 0.75 pg DNA and 1.32 ng DNA [...] one KK smear and FECT were poorer (sensitivities of 91.4% [95% CI, 81.0 to 97.1%,], 62.3% [95% CI, 49.8 to 73.7%], and 49.3% [95% CI, 37.0 to 61.6%], respectively). PCR may be a valuable and sensitive diagnostic
Epidemiology of brucellosis, Q fever and Rift Valley fever at the human and livestock interface in northern Côte d'Ivoire (Publications)
indirect ELISA. Seroprevalence of Brucella spp. in cattle adjusted for clustering was 4.6%. Cattle aged 5-8 years had higher odds of seropositivity than those aged=4years (OR=3.5). Seropositivity in cattle was [...] was associated with having joint hygromas (OR=9), sharing pastures with small ruminants (OR=5.8) and contact with pastoralist herds (OR=11.3). Seroprevalence of Q Fever was 13.9% in cattle, 9.4% in sheep
Rhinitis in Swiss adults is associated with asthma and early life factors, but not second hand tobacco smoke or obesity (Publications)
second SAPALDIA Study. Interviewer administered questionnaires were completed by 8047 participants from 8 communities in Switzerland. Blood was collected from 5841 participants and tested for allergen specific [...] rhinitis was increased in subjects with physician diagnosed asthma (Relative Risk Ratio 6.81; 95%CI 5.39, 8.6), maternal atopy (1.56; 1.27, 1.92) and paternal atopy (1.41; 1.11, 1.79). Older subjects were at
Mortality along the continuum of HIV care in Rwanda: a model-based analysis (Publications)
population on ART. Deaths among those LTFU made up 11.8% of all deaths among HIV-infected individuals in 2014, and in the base case this portion increased to 18.8% in 2025, while the contribution to mortality
