Searched for "8".

1. Terpenoids from the oleo-gum-resin of <em>Boswellia serrata</em> and their antiplasmodial effects <em>in vitro</em> (Publications)

   Terpenoids from the oleo-gum-resin of <em>Boswellia serrata</em> and their antiplasmodial effects <em>in vitro</em>

   Relevance:

   1S,3E,7R,8R,11E-7,8-epoxy-cembra-3,11-dien-1-ol (4), incensole oxide (5), rel (1S,3R,7E,11S,12R)-1,12-epoxy-4-methylenecembr-7-ene-3, 11-diol (6), isoincensole oxide (7), and isodecaryiol (8). Furthermore [...] aldehyde (13), 5alpha-tirucalla-8,24-dien-3alpha-ol (14), isoflindissone lactone (15), isoflindissol lactone (16), rel (8R,9S,20R)-tirucall-24-ene-3beta,20-diol (17), and rel (3alpha,8R, 9S,20R,24S)-20,24-epo [...] for the first time. Compounds 13 - 15 are isolated as natural products for...

2. Terpenoids from the oleo-gum-resin of <em>Boswellia serrata</em> and their antiplasmodial effects <em>in vitro</em> (Publications)

   Terpenoids from the oleo-gum-resin of <em>Boswellia serrata</em> and their antiplasmodial effects <em>in vitro</em>

   Relevance:

   1S,3E,7R,8R,11E-7,8-epoxy-cembra-3,11-dien-1-ol (4), incensole oxide (5), rel (1S,3R,7E,11S,12R)-1,12-epoxy-4-methylenecembr-7-ene-3, 11-diol (6), isoincensole oxide (7), and isodecaryiol (8). Furthermore [...] aldehyde (13), 5alpha-tirucalla-8,24-dien-3alpha-ol (14), isoflindissone lactone (15), isoflindissol lactone (16), rel (8R,9S,20R)-tirucall-24-ene-3beta,20-diol (17), and rel (3alpha,8R, 9S,20R,24S)-20,24-epo [...] for the first time. Compounds 13 - 15 are isolated as natural products for...

3. Antiprotozoal activity of diterpenoids isolated from <em>Zhumeria majdae</em>- absolute configuration by circular dichroism (Publications)

   Antiprotozoal activity of diterpenoids isolated from <em>Zhumeria majdae</em>- absolute configuration by circular dichroism

   Relevance:

   11,14-dihydroxy-8,11,13-abietatrien-7-one (6) exhibited a promising biological activity against P. falciparum (IC50 8.65 muM), with a selectivity index (SI) of 4.6, and lanugon Q (8) showed an IC50 value [...] rhodesiense. CONCLUSION: Altogether, according to the results, of 8 isolated compounds, dihydroxy-8,11,13-abietatrien-7-one (6) and lanugon Q (8) exhibited a promising activity against T. b. rhodesiense and

4. Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and... (Publications)

   Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies

   Relevance:

   by 7,8-dihydroxyflavone (50% inhibitory concentration [IC50], 68 ng/ml), followed by 3-hydroxyflavone, rhamnetin, and 7,8,3',4'-tetrahydroxyflavone (IC50s, 0.5 microg/ml) and catechol (IC50, 0.8 microg/ml) [...] vone, luteolin, and quercetin were the most potent, giving IC50s of 0.6, 0.7, 0.8, and 1.0 microg/ml, respectively. 7,8-Dihydroxyflavone and quercetin appeared to ameliorate parasitic infections in mouse [...] s by two different approaches. However, our results can help in...

5. Prevalence of atopy and pollinosis in the adult population of Switzerland (SAPALDIA study) (Publications)

   Prevalence of atopy and pollinosis in the adult population of Switzerland (SAPALDIA study)

   Relevance:

   highest rate was observed for grass (12.7%), followed by house dust mite (8.9%), silver birch (7.9%), cat (3.8%) and dog (2.8%), whereas moulds and Parietaria elicited less than 1% positive SPTs. The [...] and/or a positive SPT (total 23%; males 25.0%, females 20.8%; p < 0.001), 32.3% of the study population were considered atopic (males 35.7%, females 28.8%; p < 0.001). Concerning the prevalence of skin sensitization [...] present here prevalence data for atopy, pollinosis and atopic asthma...

6. Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and... (Publications)

   Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies

   Relevance:

   by 7,8-dihydroxyflavone (50% inhibitory concentration [IC50], 68 ng/ml), followed by 3-hydroxyflavone, rhamnetin, and 7,8,3',4'-tetrahydroxyflavone (IC50s, 0.5 microg/ml) and catechol (IC50, 0.8 microg/ml) [...] vone, luteolin, and quercetin were the most potent, giving IC50s of 0.6, 0.7, 0.8, and 1.0 microg/ml, respectively. 7,8-Dihydroxyflavone and quercetin appeared to ameliorate parasitic infections in mouse [...] s by two different approaches. However, our results can help in...

7. Prevalence of atopy and pollinosis in the adult population of Switzerland (SAPALDIA study) (Publications)

   Prevalence of atopy and pollinosis in the adult population of Switzerland (SAPALDIA study)

   Relevance:

   highest rate was observed for grass (12.7%), followed by house dust mite (8.9%), silver birch (7.9%), cat (3.8%) and dog (2.8%), whereas moulds and Parietaria elicited less than 1% positive SPTs. The [...] and/or a positive SPT (total 23%; males 25.0%, females 20.8%; p < 0.001), 32.3% of the study population were considered atopic (males 35.7%, females 28.8%; p < 0.001). Concerning the prevalence of skin sensitization [...] present here prevalence data for atopy, pollinosis and atopic asthma...

8. Antiprotozoal activity of diterpenoids isolated from <em>Zhumeria majdae</em>- absolute configuration by circular dichroism (Publications)

   Antiprotozoal activity of diterpenoids isolated from <em>Zhumeria majdae</em>- absolute configuration by circular dichroism

   Relevance:

   11,14-dihydroxy-8,11,13-abietatrien-7-one (6) exhibited a promising biological activity against P. falciparum (IC50 8.65 muM), with a selectivity index (SI) of 4.6, and lanugon Q (8) showed an IC50 value [...] rhodesiense. CONCLUSION: Altogether, according to the results, of 8 isolated compounds, dihydroxy-8,11,13-abietatrien-7-one (6) and lanugon Q (8) exhibited a promising activity against T. b. rhodesiense and

9. A sister lineage of the <em>Mycobacterium tuberculosis </em>complex discovered in the African Great Lakes region (Publications)

   A sister lineage of the <em>Mycobacterium tuberculosis </em>complex discovered in the African Great Lakes region

   Relevance:

   as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages [...] lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene

10. A sister lineage of the <em>Mycobacterium tuberculosis </em>complex discovered in the African Great Lakes region (Publications)

    A sister lineage of the <em>Mycobacterium tuberculosis </em>complex discovered in the African Great Lakes region

    Relevance:

    as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages [...] lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene