The early development of wheeze: environmental determinants and genetic susceptibility at 17q21 (Publications)
to wheeze (0.44, 0.33-0.60). Both effects were similarly observed in children with transient wheeze up to age 3 years without subsequent development of asthma (1.71, 1.09-2.67 and 0.48, 0.30-0.76, respectively)
Serum levels and genotype distribution of alpha1-antitrypsin in the general population (Publications)
AAT were found in the serum (g/litre): 1.050-1.640 for PI*MM, 0.880-1.369 for PI*MS, 0.730-1.060 for PI*SS, 0.660-0.997 for PI*MZ and 0.490-0.660 for PI*SZ. There was very little overlap in AAT serum levels
Prevalence of atopy and pollinosis in the adult population of Switzerland (SAPALDIA study) (Publications)
females 25.0%; p < 0.001) and/or a positive SPT (total 23%; males 25.0%, females 20.8%; p < 0.001), 32.3% of the study population were considered atopic (males 35.7%, females 28.8%; p < 0.001). Concerning [...] atopic rhinitis (rhinitis symptoms associated with atopy) was 13.5% (males 14.3%, females 12.6%; p < 0.05) and the prevalence of current hay fever varied between 9.1% (questionnaire answer and a positive
Associations between key intervention coverage and child mortality: an analysis of 241 sub-national regions of sub-Saharan Africa (Publications)
[odds ratio (OR) 0.698, 95% confidence interval (CI) 0.564, 0.864], and continued breastfeeding was associated with a 24% decrease in the odds of child mortality (OR 0.759, 95% CI 0.642, 0.898). Our results
Risk factors for new infection with Leptospira in meat workers in New Zealand (Publications)
was 11.3% (95% CI 8.5% to 14.8%), in deer meat workers it was 0% (95% CI 0.0% to 10.9%) and in those processing beef cattle, 1.2% (95% CI 0.2% to 4.6%). Risk factors for new infection in sheep abattoirs [...] high-risk material (bladder, and kidneys; RR 5.2, 95% CI 1.7 to 16.0). Risk was lower in the offal/pet food area (RR 4.1, 95% CI 1.0 to 16.4), and lowest in the boning room or office. Wearing personal
Data-driven adult asthma phenotypes based on clinical characteristics are associated with asthma outcomes twenty years later (Publications)
ORs (95%CI) for asthma exacerbations varied from 0.9 (0.4 to 2.0) to 4.0 (2.0 to 7.8) and the regression estimates (95%CI) for FEV1% predicted varied from 0.6 (-3.5 to 4.6) to -9.9 (-14.2 to -5.5) between
Hypertension control and retention in care among HIV-infected patients: the effects of co-located HIV and chronic noncommunicable disease care (Publications)
decreasing systolic BP by 0.76 mm Hg (P < 0.001), diastolic BP by 1.28 mm Hg (P < 0.001), and increasing the probability of BP 1 year improved by 7 percentage points (P < 0.001), adherence to HIV care [...] care improved by 6.8 percentage points (P < 0.001) and retention in HIV care with no gaps > 6 months increased by 10.5 percentage points (P < 0.001). CONCLUSION: A CDM program that co-locates NCD and HIV
Risk reduction of diarrhea and respiratory infections following a community health education program - a facility-based case-control study in rural... (Publications)
(adjusted OR 0.62, 95% CI 0.41-0.96). A similar risk reduction was observed for participants in the study who resided in areas with water improvement initiatives (adjusted OR 0.65, 95% CI 0.47-0.90). Variables
The risk of malarial infections and disease in Papua New Guinean children (Publications)
malaria (0.06/year). Children greater than nine years of age had a reduced risk of acquiring P. vivax infections of low-to-moderate (> 150/microL) density (adjusted hazard rate [AHR] = 0.65 and 0.42), whereas [...] of P. falciparum infection was only seen for parasitemias > 5,000/microL (AHR = 0.49) and symptomatic episodes (AHR = 0.51). Infection and symptomatic episodes with P. malariae and P. ovale were rare.
Effect of combinations of marketed human anthelmintic drugs against <em>Trichuris muris</em> <em>in vitro</em> and <em>in vivo</em> (Publications)
tin (Combination index (CI)=0.16), mebendazole-levamisole (CI=0.17) and albendazole-mebendazole (CI=0.23). For albendazole-ivermectin, moderate synergism was observed (CI=0.81) and for albendazole-levamisole [...] amisole a nearly additive effect was documented (CI=0.93) in vivo. Five combinations (albendazole-pyrantel pamoate, mebendazole-pyrantel pamoate, levamisole-pyrantel pamoate, levamisole-ivermectin and
