Cell penetration, herbicidal activity, and <em>in-vivo</em>-toxicity of oligo-arginine derivatives and of novel guanidinium-rich compounds derived... (Publications)
synthesized Adp(8)-derivatives (Figure5). Intravenouse injection of H-Adp(8)-NH2 into the tail vein of mice with doses as high as 45mol/kg causes no symptoms whatsoever (Table3), but H-Adp(8)-NH2 is not cell [...] cells, Figure6). On the other hand, the fluorescently labeled octamers FAM-(Adp(OMe))(8)-NH2 and FAM-(Adp(NMe2))(8)-NH2 with ester and amide groups in the side chains exhibit mediocre to high cell-wall [...] reasons for this behavior are discussed (Figure7) and corresponding NMR...
Cell penetration, herbicidal activity, and <em>in-vivo</em>-toxicity of oligo-arginine derivatives and of novel guanidinium-rich compounds derived... (Publications)
synthesized Adp(8)-derivatives (Figure5). Intravenouse injection of H-Adp(8)-NH2 into the tail vein of mice with doses as high as 45mol/kg causes no symptoms whatsoever (Table3), but H-Adp(8)-NH2 is not cell [...] cells, Figure6). On the other hand, the fluorescently labeled octamers FAM-(Adp(OMe))(8)-NH2 and FAM-(Adp(NMe2))(8)-NH2 with ester and amide groups in the side chains exhibit mediocre to high cell-wall [...] reasons for this behavior are discussed (Figure7) and corresponding NMR...
Pyridine-4(1<em>H</em>)-one alkaloids from <em>Waltheria indica</em> as antitrypanosomatid agents (Publications)
pyridine-4(1H)-one derivatives, namely, 8-demethoxywaltherione F (1), waltheriones R-V (2, 6, 7, 10, and 11), 1-methoxywaltherione O (3), (S)-15-hydroxywaltherione G (4), (8R)-8-hydroxywaltherione M (5), (9S,1 [...] 13S)-2-hydroxymethylwaltherione C (8), (9S,10S,13S)-10-hydroxywaltherione C (9), and (S)-13-methoxywaltherione V (12), as well as melovinone (13) and 5'-methoxywaltherione A (14) were isolated from the [...] es M, P, and Q showed potent growth inhibition toward Trypanosoma cruzi with...
Seroprevalence of Rift Valley fever, Q fever, and brucellosis in ruminants on the southeastern shore of Lake Chad (Publications)
The apparent RVF seroprevalence by species was 37.8% (95% confidence interval [CI] 34.2-41.3) in cattle, 18.8% (95% CI 12.3-25.2) in goats, and 10.8% (95% CI 3.0-18.5) in sheep. For brucellosis and Q [...] analyzed. For Q fever, the apparent seroprevalence was 7.8% (95% CI 5.6-10.1). For brucellosis, the RBT showed a prevalence of 5.7% (95% CI 3.8-7.6), and ELISA showed 11.9% (95% CI 9.3-14.6) with a kappa
Antiprotozoal sesquiterpene lactones and other constituents from <em>Tarchonanthus camphoratus</em> and <em>Schkuhria pinnata</em> (Publications)
5S*,6R*,7R*,8R*,10R*)-1-hydroxy-8-[5''-hydroxy-4'-(2''-hydroxyisovaleroyloxy )tigloyloxy]-3-oxoeudesma-11(13)-en-6,12-olide (3), and two new germacranolides, 3beta-(2''-hydroxyisovaleroyloxy)-8beta-(3-fu [...] royloxy)costunolide (14) and 1(10)-epoxy-3beta-hydroxy-8beta-[5'-hydroxy-4'-(2''-hydroxyisovaleroyloxy)tigloyl oxy]costunolide (16), were obtained. Additionally, the flavonoid pectolinarigenin (24) and [...] line) were evaluated for all the compounds....
Pyridine-4(1<em>H</em>)-one alkaloids from <em>Waltheria indica</em> as antitrypanosomatid agents (Publications)
pyridine-4(1H)-one derivatives, namely, 8-demethoxywaltherione F (1), waltheriones R-V (2, 6, 7, 10, and 11), 1-methoxywaltherione O (3), (S)-15-hydroxywaltherione G (4), (8R)-8-hydroxywaltherione M (5), (9S,1 [...] 13S)-2-hydroxymethylwaltherione C (8), (9S,10S,13S)-10-hydroxywaltherione C (9), and (S)-13-methoxywaltherione V (12), as well as melovinone (13) and 5'-methoxywaltherione A (14) were isolated from the [...] es M, P, and Q showed potent growth inhibition toward Trypanosoma cruzi with...
Seroprevalence of Rift Valley fever, Q fever, and brucellosis in ruminants on the southeastern shore of Lake Chad (Publications)
The apparent RVF seroprevalence by species was 37.8% (95% confidence interval [CI] 34.2-41.3) in cattle, 18.8% (95% CI 12.3-25.2) in goats, and 10.8% (95% CI 3.0-18.5) in sheep. For brucellosis and Q [...] analyzed. For Q fever, the apparent seroprevalence was 7.8% (95% CI 5.6-10.1). For brucellosis, the RBT showed a prevalence of 5.7% (95% CI 3.8-7.6), and ELISA showed 11.9% (95% CI 9.3-14.6) with a kappa
Antiprotozoal sesquiterpene lactones and other constituents from <em>Tarchonanthus camphoratus</em> and <em>Schkuhria pinnata</em> (Publications)
5S*,6R*,7R*,8R*,10R*)-1-hydroxy-8-[5''-hydroxy-4'-(2''-hydroxyisovaleroyloxy )tigloyloxy]-3-oxoeudesma-11(13)-en-6,12-olide (3), and two new germacranolides, 3beta-(2''-hydroxyisovaleroyloxy)-8beta-(3-fu [...] royloxy)costunolide (14) and 1(10)-epoxy-3beta-hydroxy-8beta-[5'-hydroxy-4'-(2''-hydroxyisovaleroyloxy)tigloyl oxy]costunolide (16), were obtained. Additionally, the flavonoid pectolinarigenin (24) and [...] line) were evaluated for all the compounds....
In vitro susceptibility of <em>P. falciparum</em> populations from Colombia and Tanzania to a new synthetic peroxide (OZ277) (Publications)
ng/mL [0.34-8] (4.4 nM [0.6-14]) and Tanzania with 1.5 ng/mL [0.22-10] (2.65 nM [0.4-17.7]). The potency of OZ277 was similar to artesunate, showing median IC(50) values of 1.5 ng/mL [0.42-8.6] (3.8 nM [1.1-22 [...] 1-22.3]) and 1.8 ng/mL [0.2-10] (4.7 nM [0.5-26.04]) in Colombia and Tanzania, respectively. These results support the development of this new antimalarial compound
In vitro susceptibility of <em>P. falciparum</em> populations from Colombia and Tanzania to a new synthetic peroxide (OZ277) (Publications)
ng/mL [0.34-8] (4.4 nM [0.6-14]) and Tanzania with 1.5 ng/mL [0.22-10] (2.65 nM [0.4-17.7]). The potency of OZ277 was similar to artesunate, showing median IC(50) values of 1.5 ng/mL [0.42-8.6] (3.8 nM [1.1-22 [...] 1-22.3]) and 1.8 ng/mL [0.2-10] (4.7 nM [0.5-26.04]) in Colombia and Tanzania, respectively. These results support the development of this new antimalarial compound
