Soil-transmitted helminth infections and risk factors in preschool children in southern rural Lao People's Democratic Republic (Publications)
The current widespread school-based control of soil-transmitted helminth (STH) infections is also advocated for preschool children. The objective of this study was to assess infection with STHs as well
water. STH infections are caused by the roundworm Ascaris lumbricoides , two hookworm species and the whipworm Trichuris trichiura . Only very few drugs are registered for treatment and control of STH infections [...] combination drug clinical trial in Laos. (Photo: Eveline Hürlimann, Swiss TPH) Soil-transmitted helminths (STH) affect one in five people in the world causing numerous health problems, including abdominal pain [...] es is done within preventive chemotherapy schemes. The usage of...
Efficacy and reinfection with soil-transmitted helminths 18-weeks post-treatment with albendazole-ivermectin, albendazole-mebendazole,... (Publications)
the current strategy to control soil-transmitted helminth (STH) infections (i.e. Ascaris lumbricoides, hookworm and Trichuris trichiura). STH reinfections, in particular A. lumbricoides and T. trichiura [...] several rounds of treatment in order to develop recommendations for appropriate control approaches for STH infections. TRIAL REGISTRATION: Current Controlled Trials ISRCTN80245406
Efficacy and safety of co-administered ivermectin plus albendazole for treating soil-transmitted helminths: a systematic review meta-analysis and... (Publications)
BACKGROUND: The soil-transmitted helminths (STH), Ascaris lumbricoides, Trichuris trichiura and hookworms infect 1.5 billion people worldwide and cause an estimated burden of 3.3 million disability-adjusted [...] plus albendazole is widely used against lymphatic filariasis, but its efficacy and safety against STH infections has not yet been fully understood. METHODS AND FINDINGS: We conducted a systematic literature [...] gov) from 1960 to January 2018. Four studies reporting efficacy of...
Efficacy and reinfection with soil-transmitted helminths 18-weeks post-treatment with albendazole-ivermectin, albendazole-mebendazole,... (Publications)
the current strategy to control soil-transmitted helminth (STH) infections (i.e. Ascaris lumbricoides, hookworm and Trichuris trichiura). STH reinfections, in particular A. lumbricoides and T. trichiura [...] several rounds of treatment in order to develop recommendations for appropriate control approaches for STH infections. TRIAL REGISTRATION: Current Controlled Trials ISRCTN80245406
Efficacy and safety of co-administered ivermectin plus albendazole for treating soil-transmitted helminths: a systematic review meta-analysis and... (Publications)
BACKGROUND: The soil-transmitted helminths (STH), Ascaris lumbricoides, Trichuris trichiura and hookworms infect 1.5 billion people worldwide and cause an estimated burden of 3.3 million disability-adjusted [...] plus albendazole is widely used against lymphatic filariasis, but its efficacy and safety against STH infections has not yet been fully understood. METHODS AND FINDINGS: We conducted a systematic literature [...] gov) from 1960 to January 2018. Four studies reporting efficacy of...
Effect of combinations of marketed human anthelmintic drugs against <em>Trichuris muris</em> <em>in vitro</em> and <em>in vivo</em> (Publications)
ABSTRACT: BACKGROUND: Soil-transmitted helminth (STH) infections are responsible for a huge public health burden, however treatment options are limited. The discovery and development of novel efficacious [...] efficacious drugs or drug combinations for the treatment of STH infections therefore has a high research priority. METHODS: We studied drug combination effects using the main standard anthelmintics, albendazole
Effect of combinations of marketed human anthelmintic drugs against <em>Trichuris muris</em> <em>in vitro</em> and <em>in vivo</em> (Publications)
ABSTRACT: BACKGROUND: Soil-transmitted helminth (STH) infections are responsible for a huge public health burden, however treatment options are limited. The discovery and development of novel efficacious [...] efficacious drugs or drug combinations for the treatment of STH infections therefore has a high research priority. METHODS: We studied drug combination effects using the main standard anthelmintics, albendazole
infections are a major public health issue in low and middle-income countries. Soil-transmitted helminth (STH) infections affect 1.5 billion people globally. They are caused by different species of parasitic worms [...] in areas where sanitation is poor. Two main drugs - albendazole and mebendazole – are used to treat STH as preventive chemotherapy. They have been used for many years both in human and veterinary medicine [...] chemotherapy programmes. Tribendimidine has to date only been...
Development and evaluation of a multiplex quantitative real-time polymerase chain reaction for hookworm species in human stool (Publications)
evaluated using DNA extracted from 192 fecal samples collected as part of a soil-transmitted helminth (STH) survey in northern Cambodia. The prevalence of hookworms as detected by the multiplex hookworm qPCR [...] detection of both N. americanus (Kappa 0.943) and Ancylostoma spp. (Kappa 0.936) with a multiplex STH qPCR. A strong and moderate quantitative correlation between cycle threshold and eggs per gram (EPG)
