Diagnosis of <em>Schistosoma </em>infection in non-human animal hosts: a systematic review and meta-analysis (Publications)
animal hosts. The pooled estimate of sensitivity was 0.21 (95% confidence interval (CI): 0.03-0.48) with FEA-SD showing highest sensitivity (0.89, 95% CI: 0.65-1.00). CONCLUSIONS/SIGNIFICANCE: Our findings
Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from <em>Allanblackia monticola</em> and <em>Symphonia globulifera</em> (Publications)
leishmanicidal activity in vitro, with IC50 values (0.2 mu M and 0.16 mu M, respectively) comparable to that of the reference compound, miltefosine (0.46 mu M). Although the leishmanicidal activity is promising [...] butylcholinesterase (AChE). For ACNE, the IC50 value (0.66 mu M) of garcinol (2) was almost equal to that of the reference compound galanthamine (0.50 mu M). Furthermore, guttiferone A (1) and guttiferone
Brucellosis and bovine tuberculosis prevalence in livestock from pastoralist communities adjacent to Awash National Park, Ethiopia (Publications)
cut-off, individual apparent prevalence was 0.9% (95%CI: 0.23-3.56%) in cattle and 0.7% (95%CI: 0.12-3.45%) in goats. Herd prevalence in Oromia and Afar sites was 0% and 66.7% respectively in goats and 16
Pharmacokinetics-pharmacodynamics analysis of spiroindolone analogs and KAE609 in a murine malaria model (Publications)
above 2*IC99 within 48 hrs (%T> TRE) and the AUC0-48/TRE correlated well with parasite reduction (R2=0.97 and 0.95, respectively), less so for the Cmax/TRE (R2=0.88). The present results suggest that for KAE609 [...] KAE609 and supposedly for its analogs dosing regimens covering T> TRE of 100 %, AUC0-48/TRE of 587 and Cmax/TRE of 30 are likely to result in maximum reduction in parasitemia in the P. berghei mouse model
The mode of action of spatial repellents and their impact on vectorial capacity of<em> Anopheles gambiae sensu stricto</em> (Publications)
In the semi-field Tunnel, coils placed 0.3 m from the human reduced feeding by 86% (95% CI [0.66; 0.95]) when used as a "bubble" compared to 65% (95% CI [0.51; 0.76]) when used as a "point source". Mosquitoes
Glutathione transferase null genotype, broccoli, and lower prevalence of colorectal adenomas (Publications)
quartile of broccoli intake (an average of 3.7 servings per week) had an odds ratio of 0.47 (95% confidence interval, 0.30-0.73) for colorectal adenomas, compared with subjects who reportedly never ate broccoli [...] of broccoli was observed only among subjects with the GSTM1 null genotype (P for trend, 0.001; P for interaction, 0.01). The observed broccoli-GSTM1 interaction is compatible with an isothiocyanate mechanism
Cynaropicrin: the first plant natural product with <em>in vivo</em> activity against <em>Trypanosoma brucei</em> (Publications)
RHODESIENSE (IC (50) of 0.3 microM) and T. BRUCEI GAMBIENSE (IC (50) of 0.2 microM), compared to TRYPANOSOMA CRUZI (IC (50) of 4.4 microM) and PLASMODIUM FALCIPARUM (IC (50) of 3.0 microM). Testing against [...] against melarsoprol- and pentamidine-resistant strains (IC (50)s of 0.3 microM and 0.1 microM, respectively) showed no cross-resistance. Intraperitoneal administration of 2 x 10 mg/kg body weight/day in the
Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis (Publications)
OR of the association between anemia and malaria alone was 1.53 (0.97-2.42), while the association between anemia and STH alone was 0.28 (0.04-1.95). There is no good evidence to support a different effect [...] association with malaria infection compared with those without (summary OR: 1.36; 95% CI: 1.17-1.59; I(2): 0%). Among non-pregnant adults, the summary OR of the association between anemia and the combined malaria [...] a higher risk of malaria infection in the primigravidae (summary OR:...
Use of B-type natriuretic peptide for the management of women with dyspnea (Publications)
admission (73% vs 86%, p = 0.034) and intensive care (12% vs 23%, p = 0.048). Median time to discharge was 6 days in the BNP group versus 10 days in the control group (p = 0.023). Total cost of treatment [...] control group (95% confidence interval 5,611 to 8,074, p = 0.009). In-hospital mortality rates were 4% in the BNP group and 10% in the control group (p = 0.165). Thus, used in conjunction with other clinical
Water quality, sanitation, and hygiene conditions in schools and households in Dolakha and Ramechhap districts, Nepal: results from a cross-sectional... (Publications)
samples for pH (6.8-7.6), free and total residual chlorine (0.1-0.5 mg/L), mean lead concentration (0.01 mg/L), and mean arsenic concentration (0.05 mg/L) were within national drinking water quality standards [...] with drinking water contamination (adjusted odds ratio: 1.64; 95% confidence interval: 1.08-2.50; p = 0.02). Our findings call for an improvement of WASH conditions at the unit of school, households, and
