Development and validation of an enantioselective LM-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in... (Publications)
mode using selected reaction monitoring (R- and S-PZQ: m/z 312.2?202.2; R-trans -4-OH-PZQ: m/z 328.0?202.0). Prior to the chiral separation with a cellulose tris(3-chloro-4-methylphenylcarbamate) column, [...] and concentrated on a C-18 trapping column. The analytical range for each PZQ enantiomer was 0.01-2.5µg/mL, and 0.1-25µg/mL for the metabolite. The method met the requirements regarding precision (±15%, ±20% [...] quantification-LLOQ), intra- and inter-assay accuracy (85-115%, 80-120% at...
Development of West-European PM2.5 and NO2 land use regression models incorporating satellite-derived and chemical transport modelling data (Publications)
the LUR model without SAT and CTM (adjR2: 0.33-0.38). For NO2 CTM improved prediction modestly (adjR2: 0.58) compared to models without SAT and CTM (adjR2: 0.47-0.51). Both monitoring networks are capable
Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role? (Publications)
exposure to HMW allergens (p = 0.009), in particular to latex (p = 0.01). In the unexposed group, the DPB1*03:01 allele was associated with adult-onset asthma (OR 0.67, 95%CI 0.53-0.86). HMW allergen exposures
Public exposure to radiofrequency electromagnetic fields in everyday microenvironments: an updated systematic review for Europe (Publications)
environments. Mean RF-EMF exposure in homes, schools and offices were between 0.04 and 0.76V/m. Mean outdoor exposure values ranged from 0.07 to 1.27V/m with downlink signals from mobile phone base stations being [...] with increasing urbanity. Levels in public transport (bus, train and tram) and cars were between 0.14 and 0.69V/m. The highest levels, up to 1.97V/m, were measured in public transport stations with downlink
Changes in seasonality and sex ratio of scrub typhus: a case study of South Korea from 2003 to 2019 based on wavelet transform analysis (Publications)
increased in spring. With an overall male-to-female ratio being 0.68:1, the ratio has increased from 0.67:1 in 2003 to 0.78:1 in 2019 (Kendall's τ = 0.706, p [...] increased by 408.8% from 9.1 in 2003 to 37.2 in 2012, and subsequently decreased by 59.7% from 2012 to 15.0 in 2019. According to the continuous wavelet transform results, ST exhibited a dual seasonal pattern
Associations of partner age gap at sexual debut with teenage parenthood and lifetime number of partners (Publications)
a partner age gap of 3-4 years (odds ratio, 1.8) or more (2.0); they were reduced if debut occurred before age 15 and the gap was 3-4 years (0.8). Females' likelihood of reporting a high lifetime number [...] number of partners was negatively associated with age gap (0.4-0.7, depending on age at debut and length of age gap). Males' likelihood of reporting a large number of partners was positively associated with [...] and the gap was five or more years (1.7) or if debut was at ages 15-17...
Diagnosis of <em>Schistosoma </em>infection in non-human animal hosts: a systematic review and meta-analysis (Publications)
animal hosts. The pooled estimate of sensitivity was 0.21 (95% confidence interval (CI): 0.03-0.48) with FEA-SD showing highest sensitivity (0.89, 95% CI: 0.65-1.00). CONCLUSIONS/SIGNIFICANCE: Our findings
Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from <em>Allanblackia monticola</em> and <em>Symphonia globulifera</em> (Publications)
leishmanicidal activity in vitro, with IC50 values (0.2 mu M and 0.16 mu M, respectively) comparable to that of the reference compound, miltefosine (0.46 mu M). Although the leishmanicidal activity is promising [...] butylcholinesterase (AChE). For ACNE, the IC50 value (0.66 mu M) of garcinol (2) was almost equal to that of the reference compound galanthamine (0.50 mu M). Furthermore, guttiferone A (1) and guttiferone
Brucellosis and bovine tuberculosis prevalence in livestock from pastoralist communities adjacent to Awash National Park, Ethiopia (Publications)
cut-off, individual apparent prevalence was 0.9% (95%CI: 0.23-3.56%) in cattle and 0.7% (95%CI: 0.12-3.45%) in goats. Herd prevalence in Oromia and Afar sites was 0% and 66.7% respectively in goats and 16
Pharmacokinetics-pharmacodynamics analysis of spiroindolone analogs and KAE609 in a murine malaria model (Publications)
above 2*IC99 within 48 hrs (%T> TRE) and the AUC0-48/TRE correlated well with parasite reduction (R2=0.97 and 0.95, respectively), less so for the Cmax/TRE (R2=0.88). The present results suggest that for KAE609 [...] KAE609 and supposedly for its analogs dosing regimens covering T> TRE of 100 %, AUC0-48/TRE of 587 and Cmax/TRE of 30 are likely to result in maximum reduction in parasitemia in the P. berghei mouse model
