The mode of action of spatial repellents and their impact on vectorial capacity of<em> Anopheles gambiae sensu stricto</em> (Publications)
In the semi-field Tunnel, coils placed 0.3 m from the human reduced feeding by 86% (95% CI [0.66; 0.95]) when used as a "bubble" compared to 65% (95% CI [0.51; 0.76]) when used as a "point source". Mosquitoes
Glutathione transferase null genotype, broccoli, and lower prevalence of colorectal adenomas (Publications)
quartile of broccoli intake (an average of 3.7 servings per week) had an odds ratio of 0.47 (95% confidence interval, 0.30-0.73) for colorectal adenomas, compared with subjects who reportedly never ate broccoli [...] of broccoli was observed only among subjects with the GSTM1 null genotype (P for trend, 0.001; P for interaction, 0.01). The observed broccoli-GSTM1 interaction is compatible with an isothiocyanate mechanism
Cynaropicrin: the first plant natural product with <em>in vivo</em> activity against <em>Trypanosoma brucei</em> (Publications)
RHODESIENSE (IC (50) of 0.3 microM) and T. BRUCEI GAMBIENSE (IC (50) of 0.2 microM), compared to TRYPANOSOMA CRUZI (IC (50) of 4.4 microM) and PLASMODIUM FALCIPARUM (IC (50) of 3.0 microM). Testing against [...] against melarsoprol- and pentamidine-resistant strains (IC (50)s of 0.3 microM and 0.1 microM, respectively) showed no cross-resistance. Intraperitoneal administration of 2 x 10 mg/kg body weight/day in the
Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis (Publications)
OR of the association between anemia and malaria alone was 1.53 (0.97-2.42), while the association between anemia and STH alone was 0.28 (0.04-1.95). There is no good evidence to support a different effect [...] association with malaria infection compared with those without (summary OR: 1.36; 95% CI: 1.17-1.59; I(2): 0%). Among non-pregnant adults, the summary OR of the association between anemia and the combined malaria [...] a higher risk of malaria infection in the primigravidae (summary OR:...
Use of B-type natriuretic peptide for the management of women with dyspnea (Publications)
admission (73% vs 86%, p = 0.034) and intensive care (12% vs 23%, p = 0.048). Median time to discharge was 6 days in the BNP group versus 10 days in the control group (p = 0.023). Total cost of treatment [...] control group (95% confidence interval 5,611 to 8,074, p = 0.009). In-hospital mortality rates were 4% in the BNP group and 10% in the control group (p = 0.165). Thus, used in conjunction with other clinical
Water quality, sanitation, and hygiene conditions in schools and households in Dolakha and Ramechhap districts, Nepal: results from a cross-sectional... (Publications)
samples for pH (6.8-7.6), free and total residual chlorine (0.1-0.5 mg/L), mean lead concentration (0.01 mg/L), and mean arsenic concentration (0.05 mg/L) were within national drinking water quality standards [...] with drinking water contamination (adjusted odds ratio: 1.64; 95% confidence interval: 1.08-2.50; p = 0.02). Our findings call for an improvement of WASH conditions at the unit of school, households, and
Development and validation of an enantioselective LM-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in... (Publications)
mode using selected reaction monitoring (R- and S-PZQ: m/z 312.2?202.2; R-trans -4-OH-PZQ: m/z 328.0?202.0). Prior to the chiral separation with a cellulose tris(3-chloro-4-methylphenylcarbamate) column, [...] and concentrated on a C-18 trapping column. The analytical range for each PZQ enantiomer was 0.01-2.5µg/mL, and 0.1-25µg/mL for the metabolite. The method met the requirements regarding precision (±15%, ±20% [...] quantification-LLOQ), intra- and inter-assay accuracy (85-115%, 80-120% at...
Development of West-European PM2.5 and NO2 land use regression models incorporating satellite-derived and chemical transport modelling data (Publications)
the LUR model without SAT and CTM (adjR2: 0.33-0.38). For NO2 CTM improved prediction modestly (adjR2: 0.58) compared to models without SAT and CTM (adjR2: 0.47-0.51). Both monitoring networks are capable
Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role? (Publications)
exposure to HMW allergens (p = 0.009), in particular to latex (p = 0.01). In the unexposed group, the DPB1*03:01 allele was associated with adult-onset asthma (OR 0.67, 95%CI 0.53-0.86). HMW allergen exposures
Public exposure to radiofrequency electromagnetic fields in everyday microenvironments: an updated systematic review for Europe (Publications)
environments. Mean RF-EMF exposure in homes, schools and offices were between 0.04 and 0.76V/m. Mean outdoor exposure values ranged from 0.07 to 1.27V/m with downlink signals from mobile phone base stations being [...] with increasing urbanity. Levels in public transport (bus, train and tram) and cars were between 0.14 and 0.69V/m. The highest levels, up to 1.97V/m, were measured in public transport stations with downlink
