Delay in diagnosis of pulmonary tuberculosis increases the risk of pulmonary cavitation in pastoralist setting of Ethiopia (Publications)
delay [P < 0.001]; 22.2% among patients diagnosed within 30 days of illness and 51.7% if delay was over 30 days. The threshold delay that optimizes cavitation was 43 days [AUC (95% CI) = 0.67(0.62-0.72)]. Smear [...] Smear positivity was significantly increased in patients delayed over 49 days [p = 0.02]. Other factors associated with cavitation were age
Synthesis, <em>in-vitro</em> antiprotozoal activity and molecular docking study of isothiocyanate derivatives (Publications)
Leishmania donovani with IC50 values between 0.4 and 1.0microM and selectivity index (SI) ranged from 7.8 to 18.4, comparable to the standard drug miltefosine (IC50=0.7muM). Compound 7h demonstrated the best [...] antileishmanial activity with an IC50 value of 0.4microM. Seven products exhibited inhibition activity against T. brucei rhodesiense with IC50s below 2.0muM and SI between 2.7 and 29.3. Four primary amine
Malaria rapid tests, febrile illness management, and child mortality across sub-Saharan African countries (Publications)
antimalarial drugs, an increase of 0.4 percentage points (95% CI, 0.1-0.6 percentage points) in antibiotic use, and a decrease of 0.4 percentage points (95% CI, 0.1-0.8 percentage points) in the use of [...] younger than 5 years of age was associated with a reduction in child mortality of 0.34 deaths per 1000 child-years (95% CI, 0.15-0.52 deaths per 1000 child-years). The effects of malaria RDT distribution on
Speech and language sequelae of severe malaria in Kenyan children (Publications)
scores on four aspects of language ability: comprehension (p = 0.02); syntax (p = 0.02); content words (p = 0.02) and function words (p = 0.004) components of lexical semantics. CONCLUSIONS: These data
Speech and language sequelae of severe malaria in Kenyan children (Publications)
scores on four aspects of language ability: comprehension (p = 0.02); syntax (p = 0.02); content words (p = 0.02) and function words (p = 0.004) components of lexical semantics. CONCLUSIONS: These data
Ozone-related acute excess mortality projected to increase in the absence of climate and air quality controls consistent with the Paris Agreement (Publications)
increasing in all climate scenarios (from 0.17% to 0.22% total deaths), except the single scenario consistent with the Paris Climate Agreement (declines from 0.17% to 0.15% total deaths). These findings stress
Marital status disruptions and internalizing disorders of children (Publications)
unmarried families at 3 years of age, with children in unmarried families having a 0.10 higher standardized CBCL score (95% CI: 0.09-0.12; p
Evaluation of the discriminatory power of variable number tandem repeat (VNTR) typing of <em>Mycobacterium bovis</em> strains (Publications)
overall allelic diversity (h(oa)) of 0.922. We defined five loci (ETR A, B, C and MIRU 26, 27) as highly (h> 0.25), two loci (MIRU 4, and VNTR 3232) as moderately (0.11
Marital status disruptions and internalizing disorders of children (Publications)
unmarried families at 3 years of age, with children in unmarried families having a 0.10 higher standardized CBCL score (95% CI: 0.09-0.12; p
Evaluation of the discriminatory power of variable number tandem repeat (VNTR) typing of <em>Mycobacterium bovis</em> strains (Publications)
overall allelic diversity (h(oa)) of 0.922. We defined five loci (ETR A, B, C and MIRU 26, 27) as highly (h> 0.25), two loci (MIRU 4, and VNTR 3232) as moderately (0.11
