Dual strategy to design new agents targeting <em>Schistosoma mansoni</em>: advancing phenotypic and <em>Sm</em>CB1 inhibitors for improved efficacy (Publications)
In this study, we have identified and optimized two lead structures from an in-house screening, with promising results against the parasitic flatworm Schistosoma mansoni and its target protease S. mansoni [...] l properties for the compounds' in vitro activities, resulting in a dual approach to optimize the lead structures, regarding both phenotypic effects in S. mansoni newly transformed schistosomula (NTS)
Field efficacy of thermally expelled or live potted repellent plants against African malaria vectors in western Kenya (Publications)
plants and thermal expulsion of plant materials in repelling African malaria vectors in traditional houses in western Kenya. METHODS: Ocimum americanum, Lantana camara and Lippia ukambensis were tested in [...] square design was applied for randomly assigning the treatment and control plants to experimental houses over different nights. RESULTS: All plant species showed significant repellency against Anopheles [...] 5%An. arabiensis Patton and 18.5%An. gambiae sensu stricto Giles), the main...
Pyrethroid resistance in <em>Anopheles gambiae</em>, in Bomi County, Liberia, compromises malaria vector control (Publications)
Indoor Residual Spraying (IRS) have both proven to be effective malaria vector control strategies in Africa and the new technology of insecticide treated durable wall lining (DL) is being evaluated. Sustaining [...] old female adult An gambiae s.l. were tested using WHO tube (n=2027) and cone (n=580) bioassays in houses treated with DL or IRS. A sample of mosquitoes (n=169) were identified to species/molecular form [...] susceptible to bendiocarb and fenithrothion. The corrected mortality of...
Field efficacy of thermally expelled or live potted repellent plants against African malaria vectors in western Kenya (Publications)
plants and thermal expulsion of plant materials in repelling African malaria vectors in traditional houses in western Kenya. METHODS: Ocimum americanum, Lantana camara and Lippia ukambensis were tested in [...] square design was applied for randomly assigning the treatment and control plants to experimental houses over different nights. RESULTS: All plant species showed significant repellency against Anopheles [...] 5%An. arabiensis Patton and 18.5%An. gambiae sensu stricto Giles), the main...
Pyrethroid resistance in <em>Anopheles gambiae</em>, in Bomi County, Liberia, compromises malaria vector control (Publications)
Indoor Residual Spraying (IRS) have both proven to be effective malaria vector control strategies in Africa and the new technology of insecticide treated durable wall lining (DL) is being evaluated. Sustaining [...] old female adult An gambiae s.l. were tested using WHO tube (n=2027) and cone (n=580) bioassays in houses treated with DL or IRS. A sample of mosquitoes (n=169) were identified to species/molecular form [...] susceptible to bendiocarb and fenithrothion. The corrected mortality of...
Interventions to increase tuberculosis case detection at primary healthcare or community-level services (Publications)
seven non-randomized controlled studies. Nine studies were conducted in sub-Saharan Africa (Ethiopia, Nigeria, South Africa, Zambia, and Zimbabwe), six in Asia (Bangladesh, Cambodia, India, Nepal, and Pakistan) [...] Colombia); which are all high tuberculosis prevalence areas.Tuberculosis outreach screening, using house-to-house visits, sometimes combined with printed information about going to clinic, may increase tuberculosis [...] effect on tuberculosis cases detected. One trial compared...
Interventions to increase tuberculosis case detection at primary healthcare or community-level services (Publications)
seven non-randomized controlled studies. Nine studies were conducted in sub-Saharan Africa (Ethiopia, Nigeria, South Africa, Zambia, and Zimbabwe), six in Asia (Bangladesh, Cambodia, India, Nepal, and Pakistan) [...] Colombia); which are all high tuberculosis prevalence areas.Tuberculosis outreach screening, using house-to-house visits, sometimes combined with printed information about going to clinic, may increase tuberculosis [...] effect on tuberculosis cases detected. One trial compared...
Towards a coherent global framework for health financing: recommendations and recent developments (Publications)
background of these challenges and opportunities, the Working Group on Health Financing at the Chatham House Centre on Global Health Security laid out, in 2014, a set of policy responses encapsulated in 20 [...] Ababa Action Agenda, the adoption of the Sustainable Development Goals, the outbreak of Ebola in West Africa and the release of the Panama Papers. These events also represent new stepping stones towards a new
Towards a coherent global framework for health financing: recommendations and recent developments (Publications)
background of these challenges and opportunities, the Working Group on Health Financing at the Chatham House Centre on Global Health Security laid out, in 2014, a set of policy responses encapsulated in 20 [...] Ababa Action Agenda, the adoption of the Sustainable Development Goals, the outbreak of Ebola in West Africa and the release of the Panama Papers. These events also represent new stepping stones towards a new
High seroprevalence of anti-SARS-CoV-2 antibodies among Ethiopian healthcare workers (Publications)
to develop an in-house antibody testing assay, assess the prevalence of SARS-CoV-2 antibodies among Ethiopian high-risk frontline HWs. METHODS: We developed and validated an in-house Enzyme-Linked Imm [...] COVID-19 pandemic has a devastating impact on the economies and health care system of sub-Saharan Africa. Healthcare workers (HWs), the main actors of the health system, are at higher risk because of their [...] association between seropositivity and potential risk factors. RESULTS: Our...
