Intensified therapy with inhaled corticosteroids and long-acting β2-agonists at the onset of upper respiratory tract Infection to prevent chronic... (Publications)
as compared to placebo (14.6% versus 16.2%, HR 0.77, 95%CI 0.46-1.33, P=.321) but the risk of severe exacerbation was decreased by 72% (HR 0.28, 95%CI 0.11-0.74%, P=.010). In the stratified analysis, effect
DNA methylation in inflammatory pathways modifies the association between BMI and adult-onset non-atopic asthma (Publications)
pathways including glucocorticoid/PPAR signaling (p = 0.0023), MAPK signaling (p = 0.013), NF-kappaB signaling (p = 0.031), and PI3K/AKT signaling (p = 0.031) were enriched for the effect modification of BMI [...] while NLRP3-IL1B-IL17 axis was enriched for the effect modification of BMI change over 10 years (p = 0.046). DNA methylation measured in peripheral blood is consistent with inflammation as a link between
The relationship between weight indices and injuries and mortalities caused by the motor vehicle accidents: a systematic review and meta-analysis (Publications)
and a direct relationship between overweight and mortality (CI=0.979-1.167), and injuries with index of AIS+2 (CI=1.178-0.768) and AIS+3 (CI=0.48-2.186) were found. CONCLUSIONS: The prediction of injury, [...] and the degrees of injuries (CI=0.503-1.139), and mortality due to motor vehicle accident (CI=1.267-1.471). A positive relationship was found between obesity and AIS+2 (CI=0.653-1.426), and AIS+3 (CI=1.184-1
The relationship between weight indices and injuries and mortalities caused by the motor vehicle accidents: a systematic review and meta-analysis (Publications)
and a direct relationship between overweight and mortality (CI=0.979-1.167), and injuries with index of AIS+2 (CI=1.178-0.768) and AIS+3 (CI=0.48-2.186) were found. CONCLUSIONS: The prediction of injury, [...] and the degrees of injuries (CI=0.503-1.139), and mortality due to motor vehicle accident (CI=1.267-1.471). A positive relationship was found between obesity and AIS+2 (CI=0.653-1.426), and AIS+3 (CI=1.184-1
Evaluation of commercially available anthelminthics in laboratory models of human intestinal nematode infections (Publications)
009 and 0.006 mg/kg, respectively) and moxidectin and abamectin being the most effective drugs against T. muris (ED50 values of 0.2 and 0.5 mg/kg, respectively). Laboratory models for soil-transmitted h [...] of 0.03-3 muM). In vivo studies were performed in the T. muris and H. polygyrus mice models, with moxidectin and milbemycin oxime showing the highest activity against H. polygyrus (ED50 values of 0.009
A cross-sectional survey on parasitic infections in schoolchildren in a rural Tanzanian community (Publications)
(OR) 0.51, 95% confidence interval (CI) 0.27-0.96, p=0.04). Children from households with goats were at higher odds of E. histolytica/E. dispar/E. moshkovskii infection (OR 3.03, 95%CI 1.29-7.10, p=0.01)
Survival and health status of DOTS tuberculosis patients in rural Lao PDR (Publications)
ratio female/male: 0.52, mean age: 46.9 years +/- 16.9), 26 (15.1%) died. These had a lower weight at the start (34.6 vs. 40.8 kg, p < 0.001) and were less compliant (91.6% vs. 19.2%, p < 0.001) than survivors [...] survivors. Low compliance was associated with poor accessibility to health care (p = 0.01) and symptomatic improvement (p = 0.02). Survivors had persistently poor health status. They were underweight (54.7%)
Schistosomiasis and soil-transmitted helminth control in Niger: cost effectiveness of school based and community distributed mass drug administration (Publications)
of $0.58. The full economic delivery cost of school based treatment in 2005/06 was $0.76, and for community distribution was $0.46. Including only the programme costs the figures are $0.47 and $0.41 r
Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-, and hyperosmolar states (Publications)
rank correlation coefficient 0.49 and 0.77, respectively). There was a close correlation of vasopressin and copeptin concentrations (Spearman's rank correlation coefficient 0.8). Conclusion: Plasma vasopressin [...] hypertonic saline. Median plasma copeptin concentrations decreased from 3.3 (1.1-36.4) pm at baseline to 2.0 (0.9-10.4) pm after water load and increased to 13.6 (3.7-43.3) pm after hypertonic saline. Vasopressin
Treatment with human growth hormone in patients with Prader-Labhart-Willi syndrome reduces body fat and increases muscle mass and physical performance (Publications)
(n=6, age 3.8-7.0 years); group 2: underweight and prepubertal (n=3, age 0.6-4.1 years); group 3: pubertal (n=3, age 9.2-14.6 years). In group 1, height increased from -1.7 SD to -0.6 SD, while weight [...] weight decreased from 1.1 SD to 0.4 SD, with a dramatic drop in weight for height from 3.8 SD to 1.2 SD. Hand length increased from -1.5 SD to -0.4 SD and foot length from -2.5 SD to -1.4 SD. Body fat, measured
