Intensified therapy with inhaled corticosteroids and long-acting β2-agonists at the onset of upper respiratory tract Infection to prevent chronic... (Publications)
as compared to placebo (14.6% versus 16.2%, HR 0.77, 95%CI 0.46-1.33, P=.321) but the risk of severe exacerbation was decreased by 72% (HR 0.28, 95%CI 0.11-0.74%, P=.010). In the stratified analysis, effect
DNA methylation in inflammatory pathways modifies the association between BMI and adult-onset non-atopic asthma (Publications)
pathways including glucocorticoid/PPAR signaling (p = 0.0023), MAPK signaling (p = 0.013), NF-kappaB signaling (p = 0.031), and PI3K/AKT signaling (p = 0.031) were enriched for the effect modification of BMI [...] while NLRP3-IL1B-IL17 axis was enriched for the effect modification of BMI change over 10 years (p = 0.046). DNA methylation measured in peripheral blood is consistent with inflammation as a link between
Monitoring multiple sclerosis by multimodel evoked potentials: numerically versus ordinally scaled scoring systems (Publications)
between EPS and clinical disability. RESULTS: All EPS correlated with EDSS cross-sectionally (0.72?rho?0.87, all p [...] d by visual, motor, and somatosensory EP and expanded disability status scale (EDSS) at baseline (T0) and months 6, 12, 24, 36 (T4). EP results were rated according to ordinal (o), semi-quantitative (sq)
Monitoring multiple sclerosis by multimodel evoked potentials: numerically versus ordinally scaled scoring systems (Publications)
between EPS and clinical disability. RESULTS: All EPS correlated with EDSS cross-sectionally (0.72?rho?0.87, all p [...] d by visual, motor, and somatosensory EP and expanded disability status scale (EDSS) at baseline (T0) and months 6, 12, 24, 36 (T4). EP results were rated according to ordinal (o), semi-quantitative (sq)
Evaluation of seasonal malaria chemoprevention in two areas of intense seasonal malaria transmission: secondary analysis of a household-randomised,... (Publications)
country, and household clustering-was 0.13 (95% CI: 0.08, 0.20), P < 0.001 for malaria hospitalisations and deaths from malaria and 0.21 (95% CI 0.20, 0.23), P < 0.001 for uncomplicated malaria, indicating [...] preceding the survey contact, and the smallest prevalence ratio observed was 2.98 (95% CI: 1.95, 4.54), P < 0.001. The frequency of molecular markers of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) resistance
Evaluation of seasonal malaria chemoprevention in two areas of intense seasonal malaria transmission: secondary analysis of a household-randomised,... (Publications)
country, and household clustering-was 0.13 (95% CI: 0.08, 0.20), P < 0.001 for malaria hospitalisations and deaths from malaria and 0.21 (95% CI 0.20, 0.23), P < 0.001 for uncomplicated malaria, indicating [...] preceding the survey contact, and the smallest prevalence ratio observed was 2.98 (95% CI: 1.95, 4.54), P < 0.001. The frequency of molecular markers of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) resistance
Association between self-reported mobile phone use and the semen quality of young men (Publications)
lower sperm concentration (adjusted β: -0.152; 95% confidence interval: -0.316; 0.011) and a lower TSC (adjusted β: -0.271; 95% confidence interval: -0.515; -0.027). In the adjusted logistic regression
Dolutegravir in real life: self-reported mental and physical health outcomes after transitioning from efavirenz- to dolutegravir-based antiretroviral... (Publications)
sad/down/depressed' (bothered 6.0% vs. 3.3% of participants at least 'a little' before vs. after transition; adjusted p = 0.048); 'feeling nervous/anxious' (7.4% vs. 3.4%; adjusted p = 0.0009); and 'nightmares [...] dreams' (6.3% vs. 3.5%; adjusted p = 0.027). Individual PHQ-9 or SF-12 items also improved. Being symptom free across all measures increased from 5.1% to 11.4% (p < 0.0001). CONCLUSIONS: We observed no negative [...] CLINICALTRIALS: gov:...
Impact of scaling up prenatal nutrition interventions on human capital outcomes in low- and middle-income countries: a modeling analysis (Publications)
intervals (UI): -0.44, 6.26) and $8.26 billion (95% UI: -1.60, 22.4) for IFA; 4.08 million y (95% UI: 0.12, 9.68) and $18.9 billion (95% UI: 0.59, 44.6) for calcium; 5.02 million y (95% UI: 1.07, 11.0) and $18 [...] $18.1 billion (95% UI: 3.88, 39.1) for MMS; and 0.53 million y (95% UI: -0.49, 1.70) and $1.34 billion (95% UI: -1.10, 3.10 billion) for BEP supplementation. South Asia and Sub-Saharan Africa tended to have
Progress in mosquito net coverage in Papua New Guinea (Publications)
household (44.3% in 2009 P = 0.002), and 48.3% slept under a LLIN (32.5% in 2009, P = 0.001). LLIN use in children under five years amounted to 58.2%, compared to 39.5% in 2009 (P < 0.001). Significant regional [...] compared to 64.6% in 2009 (P = 0.002). Sufficient LLINs to cover all household members (one net per two people) were found in 41.3% of the households (21.4% in 2009, P < 0.001). Of all household members [...] ownership (adj. OR = 3.46) while families in high quality houses would...
