Somatostatin-based radiopeptide therapy with [Lu-DOTA]-TOC versus [ Y-DOTA]-TOC in neuroendocrine tumours (Publications)
[90Y-DOTA]-TOC was comparable (45.5 months versus 35.9 months, hazard ratio 0.91, 95 % confidence interval 0.63-1.30, p = 0.49). Subgroup analyses revealed a significantly longer survival for [177Lu-DOTA]-TOC [...] [177Lu-DOTA]-TOC treatment (1.4 vs 10.1 %, p = 0.001), while the rate of severe permanent renal toxicities was similar in both treatment groups (9.2 vs 7.8 %, p = 0.32). CONCLUSION: The present results revealed
Menopause as a predictor of new-onset asthma: a longitudinal Northern European population study (Publications)
respiratory symptoms increased in early postmenopausal (coefficient, 0.40; 95% CI, 0.06-0.75) and late postmenopausal (coefficient, 0.69; 95% CI, 0.15-1.23) women. These findings were consistent irrespective of
Microscopic diagnosis of sodium acetate-acetic acid-formalin-fixed stool samples for helminths and intestinal protozoa: a comparison among European... (Publications)
mansoni (cumulative prevalence: 51.0%) and hookworm (cumulative prevalence: 39.2%) were the predominant helminths. There was excellent agreement (kappa > 0.8; p < 0.001) among the reference laboratories [...] of S. mansoni, hookworm, Trichuris trichiura and Ascaris lumbricoides. Moderate agreement (kappa = 0.54) was found for Hymenolepis nana, and lesser agreement was observed for other, less prevalent helminths [...] prevalence: 47.1%). Substantial agreement among reference laboratories was...
Early life origins of lung ageing: early life exposures and lung function decline in adulthood in two European cohorts aged 28-73 years (Publications)
difference in FEV1/year of follow-up [95%CI] -2.04ml [-3.29;-0.80]), of older mothers, (-1.82 ml [-3.14;-0.49]) of smoking mothers (-1.82ml [-3.30;-0.34] or with younger siblings (-2.61ml [-3.85;-1.38]). Less [...] who had attended daycare (3.98ml [2.78;5.18]), and indicated in subjects with pets in childhood (0.97ml [-0.16;2.09]). High maternal age and maternal smoking appeared to potentiate effects of personal smoking
Safety, immunogenicity, and protective efficacy against controlled human malaria infection of<em> Plasmodium falciparum</em> sporozoites vaccine in... (Publications)
after 3 week CHMI (P = 0.015 by time to event, P = 0.543 by proportional analysis) and all four (100%) were uninfected after repeat 24 week CHMI (P = 0.005 by proportional, P = 0.004 by time to event analysis) [...] and costs of developing PfSPZ Vaccine to prevent malaria in Africa. Immunization with five doses at 0, 4, 8, 12, and 20 weeks of 2.7 x 10(5) PfSPZ of PfSPZ Vaccine gave 65% vaccine efficacy (VE) at 24 weeks
Pharmacokinetics of a pediatric tribendimidine dose-finding study to treat hookworm infection in African children (Publications)
curve (AUC0-22h) as predictors of drug efficacy. Dried blood spot samples of 101 children were analyzed. We observed a less than proportional and proportional exposure in dADT's median Cmax and AUC0-22h, [...] respectively, following administration of 100 mg (Cmax=853 ng/ml; AUC0-22h =3,019 h*ng/ml) and 400 mg (Cmax=2,275ng/ml; AUC0-22h =12,530 h*ng/ml) tribendimidine. There were large, dose-independent variations [...] in the time to Cmax (Tmax) and ratios of dADT to adADT. We did not...
Prevalence and risk factors for schistosomiasis among schoolchildren in two settings of Côte d’Ivoire (Publications)
main risk factor for S. haematobium infection (adjusted odds ratio (AOR) = 127.0, 95% confidence interval (CI): 25.0-634.0, p < 0.001). Fishing and washing clothes in open freshwater bodies were positively [...] employed to test for associations between variables. We found a prevalence of S. haematobium of 14.0% (166 of 1187 schoolchildren infected) and a prevalence of S. mansoni of 6.1% (66 of 1089 schoolchildren
Methods matter: a comparative review of health risk assessments for ambient air pollution in Switzerland (Publications)
oscillated from 0.40 to 2.09 (times the STE-2010 value). Regarding input data, the ratio ranged from 0.69 to 1.26 for population exposure, from 0 to 1.81 for counterfactual scenario, from 0.96 to 1.13 for
The association of road traffic noise with problem behaviour in adolescents: a cohort study (Publications)
analyses. In cross-sectional analyses, peer relationship problems increased by 0.15 units (95%CI: 0.02, 0.27; scale range: 0-10) per 10dB road traffic noise increase. In longitudinal analyses, increases
Evolution of COVID-19 mortality over time: results from the Swiss hospital surveillance system (CH-SUR) (Publications)
COVID-19 (13.0%). We found that overall in-hospital mortality was lower during the second wave of COVID-19 than in the first wave (hazard ratio [HR] 0.70, 95% confidence interval [CI] 0.63- 0.78; p
